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Biomedical subjects

S Wallace

Publications and source records attributed to S Wallace.

At least 397 records · Page 22Linked to original sources
PubMed1980

Current status of transcatheter management of neoplasms.

Transcatheter arterial infusion and arterial embolization are employed in the treatment of various neoplasms. In patients with carcinoma of the colon metastatic to the liver, the hepatic arterial infusion (HAI) of floxuridine and Mitomycin produced a 55% partial response and a 12% complete response, as well as an improved median survival of 18 months. In metastatic breast carcinoma, a 30% response was achieved. In some cases, proximal embolization of aberrant hepatic arteries was performed to redistribute the hepatic flow to a single vessel to assist infusion of the entire liver using a single catheter. Devascularization by hepatic artery embolization has also been used to treat hepatic neoplasms. Arterial occlusion of renal carcinoma, followed after four to seven days by nephrectomy and hormonal therapy, produced a 36% response rate in 49 patients with distant metastases. In 14 patients with osteosarcoma treated with cis-diaminedichloroplatinum (CDDP) arterial infusion, a 57% response rate was achieved. Benign bone tumors were treated with arterial occlusion with a 60% response rate. Tumors of the pelvis were managed by bilateral internal iliac artery infusion using CDDP. In 21 patients with recurrent bladder carcinoma, control of pain and hematuria and prolonged survival were achieved.

Antineoplastic Agents↗
PubMed1980

Hepatic arterial redistribution for intraarterial infusion of hepatic neoplasms.

An aberrant hepatic artery occurs in approximately half of the population. With increased use of selective intraarterial chemotheraphy for hepatic neoplasms, an aberrant artery becomes a significant obstacle. Occlusion of the artery was attempted to redistribute the entire hepatic arterial flow from multiple arteries to a single artery to facilitate the effect of infusion. There were six hepatic artery variations found in the ten patients evaluated for this study. The aberrant left hepatic artery was embolized in five patients, and a replaced right hepatic artery was embolized in six; one patient had embolization of two hepatic arteries. The standard embolization method used Gelfoam and a coil to achieve proximal occlusion of the hepatic artery. Redistribution of hepatic flow through intrahepatic collaterals was achieved in all cases.

Antineoplastic Agents↗
PubMed1980

A new improved coil for tapered-tip catheter for arterial occlusion.

The original coil emboli were designed for untapered-lip catheters. New coils have been designed for tapered-lip (1mm) catheters and have two helical diameters of 3 and 5 mm, respectively. The adaptation of the new coil to a tapered-tip catheter greatly simplifies its use in arterial occlusion.

Aged↗
PubMed1980

Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone: a report of 9 cases.

Solitary eosinophilic granulomas of bone are benign and tend to heal spontaneously over a period of months to years. Radiotherapy and curettage have certain risks, which may be excessive considering the benign nature of the lesion. The authors injected methylprednisolone directly into 9 pathologically proved solitary eosinophilic granulomas of bone and obtained initiation of healing and relief of pain in 8. There were no complications.

Adolescent↗
PubMed1980

A new vena cava filter: experimental animal evaluation.

A new hypothrombogenic vena cava filter in the form of a thin (0.152mm thick) wire mesh was evaluated in 18 dogs. Each filter was inserted by the femoral vein approach with a 6.5 French Teflon catheter and left in place up to eight weeks. The vena cava remained patent in all animals, and the filters trapped all but very small (1-2mm) fragments of injection radiopaque clot. Intimal proliferation at points where the wire mesh abutted against the vena caval wall ensured stabilization of the catheter's position.

Animals↗
PubMed1980

Fine-needle aspiration biopsy of the liver.

Percutaneous fine-needle aspiration biopsy of focal liver lesions was performed in 36 patients. Of the biopsies, 83% yielded enough cytologic material for a correct diagnosis, without significant complications. The primary indication for the biopsy was to document the presence of malignancy and avoid a diagnostic laparotomy.

Adenocarcinoma↗
PubMed1979

Arterial occlusion of pelvic bone tumors.

Arterial occlusion of the internal iliac artery was successful in the relief of pain due to primary and secondary neoplasms of the bony pelvis in 8 of 9 patients. These included 3 giant cell tumors, 1 aneurysmal bone cyst, 1 recurrent chondrosarcoma, 3 metastatic renal cell carcinoma and 1 metastatic clear cell sarcoma. Calcification of the margin of the lesion occurred in 3 of 4 primary neoplasms after infarction. The transcatheter arterial occlusion was accomplished utilizing Gelfoam and stainless steel coils. Although most patients experienced pain and fever for several days following the procedure, no permanent sequelae or complications were encountered.

Adenocarcinoma↗
PubMed1979

Metastatic osteogenic sarcoma to the brain.

The radiographic appearances of intracranial metastases from primary osteogenic sarcomas in three patients are presented. In two patients, the diagnosis of metastatic disease could be made on conventional roentgenograms of the skull since mineralization of tumor osteoid could be seen within the brain parenchyma. This had a similar appearance to the primary bone tumor. Angiography in two of the three patients revealed the cerebral metastases to be hypervascular with tumor vessels, tumor stain and early draining veins.

Adolescent↗
PubMed1979

Computerized tomography in rhabdomyosarcoma of the head and neck.

Rhabdomyosarcoma of the head and neck may be treated with surgery, radiotherapy and chemotherapy or a combination thereof. Precise delineation of the full extent of the tumor in the head and neck is essential. Routine radiographs with hypocycloidal tomography and CT are complementary in defining the full extent of the lesion. Tomography is superior to CT scanning in demonstrating fine bone detail. Demonstration of the soft tissue tumor and its extensions is better seen on CT. The ability to discriminate differences more accurately in densities allows computerized tomography to appreciate better the integrity of the bone margins such as the thin walls of the sinuses.

Adolescent↗
PubMed1979

Angiography in giant-cell bone tumors.

Angiography was performed on 48 patients with giant-cell bone tumors. Sixty-four per cent were hypervascular; 25% were hypo- or moderately vascular; and 10% were avascular. Findings were similar in the 45 benign and 3 malignant tumors. There was no correlation between the findings and degree of histological aggressiveness. There was a high (60%) incidence of aneurysmal bone cyst component in the hypovascular group. Hyperemic synovium, occasionally simulating tumor, was seen in 80% of surgically proved lesions. Angiography was useful in assessing tumor extent, particularly when an extraosseous component was present.

Adolescent↗
PubMed1979

Computed tomographic arteriography of the liver.

Computed tomographic arteriography (CTA) of the liver performed during intra-arterial infusion of contrast material improved the detection of hepatic lesions in 10 of 12 patients and was the only method that accurately determined the extent of disease in 6. This technique has significant advantages over conventional hepatic computed tomography with or without intravenous contrast enhancement, or selective hepatic angiography. It is recommended in the evaluation of selected patients, especially when there is a discrepancy between the findings obtained by other methods.

Angiography↗
PubMed1979

The sella turcica in primary end organ failure.

Pituitary hyperplasia, or adenoma, may result from end or target organ failure as seen in primary hypothyroidism and hypogonadism. Associated enlargement of the sella turcica and contour alterations without significant increase in volume may be seen. A review was made of 12 patients with end organ failure demonstrating the spectrum of radiologic changes within the sella turcica. Recognition of pituitary enlargement resulting from end organ failure may eliminate unnecessary surgery.

Adenoma↗
PubMed1979

Transcatheter occlusion of the gastroduodenal artery.

The gastroduodenal arteries of 7 patients were occluded for treatment of duodenal bleeding in 4, hepatic devascularization in 2, and redistribution of blood flow for intra-arterial chemotherapy in one patient. In 6 patients, occlusion was performed with Gianturco coils, and with Gelfoam in one. No major complication was encountered. This approach was successful in the control of bleeding from peptic ulcers, arteriovenous malformation and invasion of duodenum by retroperitoneal metastatic lymph nodes from carcinoma of the testicle. Occlusion of the gastroduodenal artery was utilized for further dearterialization of hepatic neoplasms. Redistribution of hepatic blood flow was accomplished by the occlusion of the gastroduodenal and replaced right hepatic arteries allowing infusion of chemotherapeutic agents into the entire liver through the left hepatic artery.

Adenoma, Bile Duct↗