[Cerebrospinal fluid polyamine in various neurological diseases].
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Biomedical subjects
Publications and source records attributed to S Waga.
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A 37-year-old man presented with a peripheral aneurysm of the left posterior inferior cerebellar artery associated with a more peripheral arteriovenous malformation fed by the same artery. Recurrent subarachnoid hemorrhage occurred from rupture of the aneurysm. Review of the pertinent literature indicates that the aneurysm of the posterior inferior cerebellar artery originates from the peripheral portion of the artery, when associated with arteriovenous malformation.
We report a 6-year-old girl with an intracranial aneurysm associated with moyamoya disease. The patient did not have a subarachnoid hemorrhage but had an ischemic attack. The aneurysm, located on the proximal portion of the lateral posterior choroidal artery, disappeared after external carotid-internal carotid anastomosis. The characteristics of the aneurysms associated with moyamoya disease are briefly reviewed. We emphasize that the treatment of choice in moyamoya disease is cerebral revascularization, because it reduces the increased blood flow through the moyamoya vessels, basilar artery and other uninvolved cerebral arteries, the sites where the aneurysms in this disease frequently develop, as the blood flow through the external carotid system is increased by such an operation.
The case of a 12-year-old girl with fibrous dysplasia involving the cranial vault is presented. The external carotid angiogram demonstrated a dilated and beaded zygomatico-orbital branch of the superficial temporal artery, a faint tumor stain, and an early filling vein. The mass was moderately vascular at the operation and histological examination demonstrated no malignancy.
We report the cases of three patients with fracture of the sella turcica. All three patients developed vascular complications. Patient 1 had a traumatic aneurysm, Patient 2 had stenosis of the intracranial internal carotid artery, and Patient 3 had bilateral carotid-cavernous fistulas. We emphasize that, when fracture of the sella turcica is demonstrated, cerebral angiography is still the method of choice for the detection of intracranial vascular injury.
Nine cases with arteriovenous malformations (AVM's) predominantly involving the lateral ventricle are presented. All the AVM's were small, but caused intraventricular hemorrhage in eight cases. Only two patients had an intracerebral hemorrhage large enough to warrant evacuation. Eight patients were under the age of 40 years at the onset of their disease. Computerized tomography demonstrated intraventricular hemorrhage in eight patients, and after intravenous administration of contrast medium a small area of enhancement with dilated subependymal draining veins was seen in seven. The lateral ventricles were of normal size in seven cases, and only two patients required a shunting procedure. Angiography demonstrated that the lesion was an AVM in eight patients, and did not visualize the lesion in the ninth. One patient suffered a recurrent intraventricular hemorrhage when the AVM was demonstrated, although repeated angiography had failed to disclose a vascular lesion at his first intraventricular hemorrhage 14 months before. All nine lesions were resected by microsurgical techniques, and the results were excellent in eight patients. Of four caudate lesions, three were resected through a frontal transcortical approach and the other was operated on through an anterior transcallosal approach; the results were excellent in three of these patients. Only one (Case 4) was left with neurological deficits; he had confusion and disorientation following a right frontal transcortical approach. Even in the dominant hemisphere, lesions in the head of the caudate nucleus could be safely resected by an anterior transcallosal approach. Two choroidal lesions located in the temporal horn and trigone on the dominant side were resected through a middle temporal gyrus approach, and three thalamic lesions through a posterior transcallosal approach, all with excellent results. In all cases the brain opening required was about the width of the retractor (maximum 2.0 cm, average 1.5 cm).
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A 50-year-old fisherman presented with numbness of the left hand and headache after a fall on the deck of a boat. Myelography revealed protrusions of the disks of C-7 and L-4. Computed tomography of the brain incidentally disclosed moderate hydrocephalus and hypoplasia of the inferior cerebellar vermis without cystic formation in the posterior fossa. The patient never developed evidence of cerebral involvement. Several entities associated with agenesis or hypoplasia of the cerebellar vermis have been described, all of which accompany abnormal clinical symptoms or signs attributable to cerebral involvement. This case is unique in that the patient has been entirely asymptomatic with this abnormality since birth.
More than one aneurysm on the same artery is uncommon. The authors represent 10 patients with such lesions. Three hundred and fifty-six patients were admitted to the department for treatment of cerebral aneurysm from January 1977 through April 1983. Fifty-nine patients had multiple aneurysms (17%). Out of 59 patients with multiple aneurysms, there were 10 patients with more than one aneurysm on the same artery. Thus the incidence was 2.8%. The aneurysm arose from the internal carotid artery in seven of these patients, from the middle cerebral artery in two, and from the anterior communicating artery in only one. In six cases, the larger aneurysm on the same artery proximal in three and distal in three, was found to have bled; in one, the smaller distal aneurysm had ruptured; in one, we could not identify which aneurysm had bled; and in two, another associated aneurysm had bled.
A congenital dermoid cyst located over the anterior fontanel is described in a Japanese infant. This is the sixth reported case of the lesion in Japanese patients. The literature is reviewed, and the concept that dermoid cysts of the anterior fontanel do not predominantly occur in blacks is supported.
A rare case of giant intraventricular noncolloid epithelial cyst associated with multicompartmental hydrocephalus in an infant is presented. The cyst was located in the third ventricle and extended through the foramina of Monro into the lateral ventricles. Multiple modes of therapy were performed, including shunting procedures and transcortical and transcallosal cystostomies. It is concluded that extensive cystostomy coupled with a shunting procedure is the preferred method of treatment for giant cystic lesions around the foramina of Monro, if total excision is not feasible.
We report three cases of the spontaneous resolution of a traumatic chronic epidural hematoma. The patients were young adults with only mild headache after trauma. All patients were treated conservatively because of the very mild symptoms and the time lapse of 1 to 2 weeks between trauma and our unexpected detection of the frontal epidural hematomas. Slow, spontaneous resolution of the hematoma occurred in all three cases.
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Twenty-four patients receiving medication for moderate to severe hypertension were studied during a six week normal diet and a six week low sodium period. Mean urinary sodium excretion was reduced from 169 +/- 13 to 92 +/- 7 mmol/24 hour yet with the exception of a small reduction in the mean erect systolic blood pressure 140.7 +/- 2.5 to 135.1 +/- 2.6; p less than 0.05) no significant alteration in the patients blood pressure was noted. Urinary potassium excretion and body weight remained unaltered. However, evaluation of the patient data when the patients were grouped into those taking thiazide diuretics (n = 14) and those not taking diuretics (n = 10) revealed a significant reduction in the mean supine systolic and diastolic and erect systolic blood pressure in the thiazide group. Significant changes in blood pressure were not recorded in the non-diuretic group. It is suggested that moderate dietary sodium restriction in combination with thiazide diuretics is of value in the treatment of moderate to severe hypertension.
Clinical studies on sulbactam/cefoperazone (SBT/CPZ) were carried out and the results were as follows: Eleven patients (pneumonia 8, acute purulent arthritis of the knee joint 1, urinary tract infection 2) were treated with SBT/CPZ, in doses of 30-67 mg/kg divided 3 times per day for 3-61/3 days intravenously. The overall efficacy rate was 100%. As to adverse reaction, diarrhea was observed in 1 case. Abnormal laboratory data were noted in 2 cases (GPT elevation in 1, and eosinophilia and GPT elevation in 1).
Ceftazidime ( CAZ ) is a newly developed cephalosporin. Clinical studies on this drug was carried out and the results were as follows. Twenty-nine patients (acute purulent tonsillitis 2, acute bronchitis 1, pneumonia 15, acute purulent lymphadenitis 2, pyoderma 1, skin abscess 2 and urinary tract infection 6) were treated with CAZ in doses of 42-1 mg/kg (mean 59 mg/kg) divided 2-3 times per day for 3-10 days (mean 5.7 days) intravenously. The overall efficacy rate was 96.6%. As to adverse reaction, drug fever was observed in 1 patient. Abnormal laboratory data were noted in 4 cases (elevation of serum GOT, GPT and BUN in 1, elevation of serum GOT and GPT in 1, elevation of BUN in 1 and leukopenia in 1).
Anastomosis of the superior thyroid artery to the cervical vertebral artery was performed with good results in a case of vertebrobasilar insufficiency caused by proximal occlusion of the vertebral artery. As a donor artery the superior thyroid artery is moderate in size, long, and easy to anastomose. It is emphasized that this cervical procedure is simpler and safer than the intracranial procedures. The authors believe this case to be the first in which the superior thyroid artery was used as a donor artery for anastomosis to the vertebral artery.