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Biomedical subjects

S Uematsu

Publications and source records attributed to S Uematsu.

At least 127 records · Page 7Linked to original sources

[The indication of hepatic resection from medical imaging technique for hepatocellular carcinoma].

Recently small hepatocellular carcinoma are frequently diagnosed due to the improvement of medical imaging techniques. Main tumors including one with diameter of 1 cm were definitely diagnosed by the combined use of US and CT. US and angiographic examination were useful in definitely detecting tumor emboli in the main trunk even to the subsegmental level of the portal vein. All of the 12 daughter nodules of diameter over 1 cm could be definitely diagnosed by any examinations. However, diagnostic accuracy was in detecting 11 daughter nodules of diameter below 1 cm as the following data shown; one was positive using US, six were positive using CT, and three were positive using angiography. Sequential moving scan technique during the late phase could make definite preoperative diagnosis of small daughter nodule of diameter below 1 cm. Owing to the improvement of the imaging diagnostic technique, we can obtain accurate preoperative information concerning the presence or absence of daughter nodule and tumor emboli in the portal vein. Therefore, we can select suitable candidates for surgical excision or other combined therapy.

Carcinoma, Hepatocellular↗

Sleep spindles recorded from deep cerebral structures in man.

The depth and scalp EEG findings in 73 patients with intractable epileptic seizure disorder and in 14 patients with intractable pain were reviewed; stress was laid on the area of earliest spindle activity. It was found that sleep spindles frequently occurred first in frontal depth leads and especially in the superior frontal region (supplementary motor region). In some cases, spindles in frontal depth leads occurred while the patient showed early drowsy activity or even waking activity (with posterior basic rhythm) in the scalp leads. In patients with thalamic implants, spindles tended to appear on the thalamus before appearance on the scalp. The general rule that sleep onset (NREM) is characterized by the appearance of spindles is valid for the scalp EEG only. Deep spindle activity occurs much earlier and probably requires a certain degree of synchronization before spindle activity is noticeable in scalp leads. The superior frontal region is likely to be the starting point of spindle activity.

Adult↗

New model of a scaling dermatosis: induction of hyperproliferation in hairless mice with eicosa-5,8,11-trienoic acid.

The present studies have demonstrated that topical application of a low concentration of eicosa-5,8,11-trienoic acid (a 20:3,n9 fatty acid previously reported to inhibit competitively the activity of the sheep vesicular cyclooxygenase) to skin of normal fed hairless mice produced severe scaly dermatosis which is characterized by marked hyperplasia and acanthosis of the epidermal layer. The precise mechanism of this induction of scaly dermatosis is presently unclear. It is nonetheless interesting that the treatment of skin with similar concentrations of other unsaturated fatty acids produced no visible or histologic effects. Furthermore, endogenous levels of arachidonic acid in epidermal phospholipid and triglyceride fractions were shown to increase significantly (p < 0.01) in skin treated with the 20:3,n9 fatty acid while the endogenous level of PGE2 in the same tissue decreased markedly. This latter observation is consistent at least in part, with a previous report from this laboratory in which the 20:3,n9 fatty acid inhibited in vitro the activity of the sheep vesicular cyclooxygenase (the rate limiting enzyme in the transformation of arachidonic acid into the prostaglandin endoperoxides) although the increase in arachidonic acid may also reflect an increased incorporation of this fatty acid into the epidermal lipids by the hyperproliferative tissue. Evaluation of the proliferative status of 20:3,n9 fatty acid-treated skin showed a significant increase (p < 0.01) in labeling and mitotic indices. The use of this potentially endogenous fatty acid may be a useful tool for further investigations of hyperproliferative skin diseases where dietary deficiency of essential fatty acids does not exist.

8,11,14-Eicosatrienoic Acid↗