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Biomedical subjects

S Ueda

Publications and source records attributed to S Ueda.

At least 1,099 records · Page 61Linked to original sources
PubMed1980

Evaluation of the effect of CDP-choline on poststroke hemiplegia employing a double-blind controlled trial. Assessed by a new rating scale for recovery in hemiplegia.

A double-blind study was conducted in order to evaluate the effect of CDP-choline on functional recovery of hemiplegia. A standardized 12-grade scale (Hemiplegia Function Test) was utilized for the evaluation. The results indicate that for the upper limbs, doses of 1,000 and 250 mg of CDP-choline were superior to placebo at 8 weeks. The higher dose showed an effect at 4 weeks equal to that at 8 weeks while the effect of the lower dose was slower but reached the same level of effect as the higher dose at 8 weeks. Similar results were obtained for the lower limbs but the effectiveness was not statistically significant. The lesser effect for the lower limbs could be attributed to the relatively small number of patients in the early stages of recovery in the present series. No significant differences were found for the effects on subjective symptoms, neurological signs and overall judgment of the physicians. The findings suggest that CDP-choline promotes natural recovery in hemiplegia.

Choline↗
PubMed1980

Hemoglobin takamatsu (beta 120 (GH 3) Lys leads to Gln): a new abnormal hemoglobin detected in three unrelated families in the takamatsu area of shikoku.

A survey of hemoglobinopathies which was carried out in the Takamatsu district during the period from January to August 1979 detected six families with abnormal hemoglobins. Approximately 6010 inhabitants were screened. Three of these families had the same new Hb variant (Hb Takamatsu beta 120 Lys leads to Gln) that has not been previously reported. Existence of a blood relationship among these three families could not be established even after careful family studies. This abnormal hemoglobin was not associated with adverse symptoms and gave normal hematologic findings in the carriers. The isopropranol test was negative, oxygen affinity was within the normal range, and biosynthetic ratio in reticulocytes was around 1.0. One of the difficulties in the structural analysis of this hemoglobin was related to complete superposition of abnormal beta XT-12b,13 on a beta T-8,9 peptide in the fingerprint of the trypsin digest of aminoethylated aberrant beta X chain. This was overcome by collection of abnormal tryptic beta core (beta XT-10-13) from unmodified beta X chain, and subsequent digestion by chymotrypsin. Edman analysis of the chymotryptic peptides thus obtained successfully confirmed the substitution to be beta 120 Lys leads to Gln.

Adult↗
PubMed1980

Enzymatic activities, activation by actin, and synthesis of cardiac atrial myosin: distinctive enzymatic properties compared with cardiac ventricular myosin.

ATPase activity and synthesis of atrial and ventricular myosin were compared in the dog and rabbit heart. Atrial myosin showed enzymatic properties characterized by high Ca2+- and Mg2+-activated ATPase activities, low activation energy, lower rate of inactivation at alkaline pH, and no activation by N-ethylmalemide compared with the same properties in ventricular myosin. These findings suggest a difference in the myosin molecule at or near the active site involfing the SH-1 thiols. Also, actin activation of ATPase activities was studied to determine the physiological significance of this observation, since, in living muscle cell, MgATP is hydrolyzed by myosin under the activating effect of actin. Actin extracted from skeletal muscle was used in this experiment. Vmax for the actin-activated Mg2+-ATPase of atrial myosin was about twice that of ventricular myosin, whereas no significant difference was observed in the apparent dissociation constant for actin. This result suggests that the change in the enzymatic properties of myosin is reflected in the contractility of atrial and ventricular muscles. However, [3H]leucine incorporation into the myosin was approximately the same, suggesting that the difference in work load between atrium and ventricle is not associated with alteration of synthesis of cardiac myosin.

Actins↗
PubMed1980

[Orbitosphenoidal encephalocele in neurofibromatosis associated with postoperative vasospasm following its surgical repair (author's transl)].

A 32-year-old woman had a history of left temporal and occipital bone defects since her infancy and she developed left exophthalmos in the last three years following a ormin head injury. The left eye ball was displaced downward and rotated nasally, and she was unable to move the left eye voluntarily beyond the mid-line. The left eye ball could not be rotated beyond the mid-line even by muscle traction. Skull x-rays and carotid angiograms showed various abnormalities of skull dysplasia and positional abnormalities of intracranial arteries. Pneumoencephalography demonstrated dilatation of the arterior and temoral horns of the left lateral ventricle. Cranioplasty was performed and postoperative vasospasm occurred in the internal carotid and middle cerebral arteries, causing right hemiparesis and aphasia. Congenital vascular abnormality in neurofibromatosis was discussed in relation to the cerebral vasospasm.

Adult↗
PubMed1980

Association of gastric cancer and nephrotic syndrome. An immunologic study in three patients.

Three patients presenting typical nephrotic syndrome concurrent with gastric cancer are described. The carcinoma was moderately advanced and was histologically an adenocarcinoma in all cases. Morphologic examination of the renal biopsy revealed the characteristic changes of membranous nephropathy and typical subepithelial electron-dense deposits. The glomerular deposits were specifically stained with antihuman IgG and beta-1-c. The eluate of the glomeruli reacted specifically with the surface of the cancer cells from the same patient when studied by the immunofluorescent method. The eluate also reacted with the cancer cell extract as examined with the radioimmunodiffusion technique and with carcinoembryonic antigen (CEA) prepared by the method of Gold. Furthermore, the nephrotic syndrome completely remitted in 1 patient following surgical removal of the cancer. These bits of evidence indicate a possible role of a stomach cancer related antigen and/or CEA in the development of immune complex nephropathy in these patients.

Adenocarcinoma↗
PubMed1980

Radioimmunoassay of cardiac myosin light chain II in the serum following experimental myocardial infarction.

A sensitive radioimmunoassay for cardiac myosin light chain II (LCII) was developed, and changes of serum LCII levels were studied in experimental myocardial infarction in dogs. This radioimmunoassay employed an antiserum which was prepared in rabbits against canine LCII. In our assay, 0.2-5.0 ng of LCII were effectively measurable. In normal dogs, LCII concentration in serum was less than 20 ng/ml. The serum LCII level began to rise within 6 hr after ligation of the left anterior descending coronary artery, reaching maximum level at 3-5 days (40-320 ng/ml). In eight out of ten cases with coronary occlusion, LCII could be detected as long as 7 days after operation. In one sham-operated dog, LCII was detected at 2 and 3 days, but its concentrations were less than 30 ng/ml. When LCII was injected intravenously, it dissipated from the blood stream within 48 hr. The time course curves of serum LCII level had two characteristics that had not been observed in serum enzyme studies: 1) LCII level rose rapidly and stayed up during a long period after coronary occlusion, and 2) changes of serum LCII levels were biphasic in six out of ten dogs with coronary occlusion. These results, and our previous studies of synthesis rate of light chains, suggest that when a coronary artery is occluded LCII may first be released from a pool of uncombined LCII in myocardial cells, and then continuously liberated from cardiac myosin molecules. This radioimmunoassay can be expected to be useful when applied to clinical use.

Animals↗