Search PubMed⌕ Search

Biomedical subjects

S Ueda

Publications and source records attributed to S Ueda.

At least 991 records · Page 55Linked to original sources
PubMed1983

New broad-spectrum cephalosporins with anti-pseudomonal activity. II. Synthesis and antibacterial activity of 7 beta-[2-acylamino-2-(4-hydroxyphenyl)acetamido]-3-[ (1-methyl-1H-tetrazol-5-yl)thiomethyl]ceph-3-em-4-carboxylic acids.

The influence of the chirality of the 7-acyl side chain and of various N-acyl moieties (A-CO-) on the in vitro activity of 7 beta-[2-acylamino-2-(4-hydroxyphenyl)acetamido ]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]ceph-3-em-4-carboxylic acids (6) was investigated. A cephalosporin having a 7-acyl side chain of S-configuration (6r) was only weakly active against Staphylococcus aureus and Klebsiella pneumoniae and was inactive against the other species tested. Among the various N-acyl moieties in the cephalosporins having a 7-acyl side chain of the R-configuration, the 4-hydroxypyridine-3-carbonyl moiety, unsubstituted or substituted with 5-bromo and/or 6-alkyl groups and the 4-hydroxy-1,5-naphthyridine-3-carbonyl moiety, unsubstituted or substituted with a 6-methyl and a 6-methoxy group gave the most active compounds. N-Ethylation of the 4-hydroxy-1,5-naphthyridine-3-carbonyl derivative and the 4-hydroxypyridine-3-carbonyl derivative (6p, 6q) resulted in a decrease of the in vitro activity.

Bacteria↗
PubMed1983

[Effect of interferon on mouse glioma].

Mouse interferon (IFN) induced in L 929 cells by Newcastle disease virus was examined for its effect on the growth of mouse brain tumor cell line. In this study, we used subcutaneously transplanted 203 Glioma model, which had been originally induced by methylcholanthrene in C 57 BL mice. After subcutaneous transplantation, intraperitoneal administration of IFN was started by following schedule; 5 X 10(3) IU twice a week, 5 X 10(4) IU twice a week, 2.5 X 10(5) IU twice a week, 5 X 10(3) IU every day and 2.5 X 10(4) IU every day. In all groups treated by IFN intraperitoneally, no inhibition of the tumor growth was seen. On the other hand, natural killer (NK) activity was augmented by IFN treatment. Therefore, we considered that augmentation of NK activity was not directly correlated with the antitumor effect of IFN. Then, local administration was examined. After subcutaneous tumor was recognized, 2.5 X 10(4) IU of IFN was injected intratumorally every day. About 20 days later, the tumor decreased its size less than that treated by local injection of saline. It was suggested that the local administration of IFN might be better than the systemic administration.

Animals↗
PubMed1983

Chemical synthesis of 2',5'-oligoribonucleotides.

Partial phenylcarbamoylation of ribonucleosides by metal carboxylates - phenyl isocyanate system was found to be induced at 2'-position with high regioselectivity in good yields, similar to that by amines - phenyl isocyanate system; these results prompted us to perform synthesis of oligoribonucleotides bearing 2'-5' phosphodiester linkage starting either from 5'-0-acetyl-2'-0-phenylcarbamoyl or from 2', 5'-bis(phenylcarbamo)yl derivatives through the sequence of reactions, i.e. tetrahydropyranylation at 3'-position, decarbamoylation and deacylation with sodium methoxide in methanol both at 2'- and 5'-positions, dimethoxytritylation at 5'-position, and phosphorylation at 2'-position with 5-chloro-8-quinolylphosphate/8-quinolinesulfonyl chloride, followed by the usual coupling procedures by Takaku et al).

Chemical Phenomena↗
PubMed1983

[Surgical management of peripheral hypoglossal nerve palsy caused by abnormal external carotid artery].

It is known that there are a number of variation and anomalies in the bifurcation of the external and internal carotid arteries. It has also been reported that the lateral position of the external carotid artery, which was formerly considered extremely rare, is not so unusual. However, there are few reports that the lateral position of the external carotid artery has caused neurological signs. In this paper, an unusual case of peripheral hypoglossal nerve palsy, attributed to the vascular compression by lateral position of the external carotid artery and abnormally high position of the bifurcation of the external and internal carotid artery was reported. A forty-nine year old man was admitted complaining of tongue deviation and dysarthria. Atrophy and fasciculation of the right lingual muscle were observed. In a right carotid angiogram, lateral position of the external carotid artery was noticed and the bifurcation of the external and internal carotid arteries was abnormally high (upper margin of C2 vertebra). The proximal portions of both arteries were very tortuous and dilated like a megadolichoartery. A right neck surgery was performed and the bifurcation of the external and internal carotid artery was exposed. The hypoglossal nerve was running just above the bifurcation. Owing to the lateral position of the external carotid artery and the tortuous dilatation of the proximal portion of the external and internal carotid arteries, the hypoglossal nerve was markedly compressed and extended laterally. The external carotid artery was ligated and cut at its origin. Inflammatory lymph nodes near the bifurcation were also removed.(ABSTRACT TRUNCATED AT 250 WORDS)

Carotid Artery, External↗