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Biomedical subjects

S Teramoto

Publications and source records attributed to S Teramoto.

At least 505 records · Page 28Linked to original sources
PubMed1978

Cytogenetic and dominant lethal studies on captan.

Possible mutagenic activity of captan was investigated by in vitro and in vivo cytogenetic studies and by the dominant lethal study in mice. In vitro cytogenetic study with cultured human diploid cells revealed a significant increase in the frequency of cells showing stickiness and a severe mitotic inhibition at concentrations of 3.0 and 4.0 microgram of captan per ml. although no chromosomal aberrations were observed. In in vivo cytogenetic study, no chromosomal aberrations were induced in the bone marrow cells of rats treated orally with captan at a single dose of 500, 1000 or 2000 mg/kg or at five consecutive doses of 200, 400 or 800 mg/kg/day. Dominant lethal study also failed to show any mutation induction after treatment of male mice with daily oral dose of 200 or 600 mg of captan per kg bw for five days.

Animals↗
PubMed1978

[Analysis of the right ventricular function by simulation (author's transl)].

In the previous experiments it was reported that either the interventricular septum of the free wall of the right ventricle was replaceable with a non-contractile prosthesis. It was also reported that a new chamber constructed on the epicardium had capability of producing a pulsatile pressure. This study was to determine contribution of the septum and the free wall on performance of the right ventricle by using a simulator. Left-ward shift of the interventricular groove was not found along the basal half of the long axis and was limited only along the apical half. Bulging of the septum toward the right ventricular cavity did not occur at all, but on contrary the septum moved toward left, denying contribution of the septal movement to pump action of the right ventricle.

Animals↗
PubMed1978

[Diabetes insipidus after surgery of intracranial arterial aneurysms--with special reference to the human ADH and aldosterone secretion (author's transl)].

The cases of diabetes insipidus (DI) after surgery of intracranial aneurysms were reported and discussed. 1. Of 112 patients operated on for intracranial arterial aneurysm (microsurgical approach), four patients (3.6%) showed DI in the postoperative period. In 3 cases of these 4, the aneurysms located on the anterior communicating artery and the remaining one was the posterior inferior cerebellar artery. 2. The exact mechanism of occurrence of DI is obscure. We suppose that not only vascular spasm of branches of the anterior cerebral and anterior communicating arteries supplying to the paraventricular and preoptic nucleus, but also surgical trauma with direct tissue injury might explain the symptoms. 3. All patients showed a monophasic type of DI which started 1 to 4 days after surgery and lasted from 6 up to 9 days. 4. Two patients with DI showed decreased plasma ADH values below 0.6 microunits/ml in the few days prior to the appearance of abnormally large amount of urinary output. Therefore, once the diagnosis of postoperative DI is made, the patients should be managed promptly with the replacement therapy of Aqueous pitressin. 5. A slow continuous infusion of Aqueous pitressin in the range of 1 to 1.5 IU/hr effectively reduce the polyuria which were not controlled by intermittent intramuscular injections.

Adult↗
PubMed1977

Myocardial protection during open-heart surgery: intermittent aortic crossclamping versus coronary perfusion.

Twenty-seven patients undergoing open-heart surgery were divided into three groups, i.e., control, intermittent aortic crossclamping and coronary perfusion groups. Myocardial oxygen extraction, lactate extraction, arterial-coronary sinus hydrogen ion difference, potassium difference and glucose difference were determined during the operation, as well as, postoperative stroke and cardiac indices and comparisons were made. When the ascending aorta was not crossclamped, myocardial metabolism was well preserved during and after the perfusion at a flow rate of 2.0 L./min/m2. Intermittent aortic crossclamping for 15 minutes alternating with a period of perfusion for five minutes at 30 degrees C was sufficient to protect the myocardium from ischemia. Perfusion of the left coronary artery alone at a flow rate of six per cent of total body perfusion (150 to 200 ml per minute) at 30 degrees C was sufficient to protect the myocardium when the aorta was opened. Since intermittent perfusion of the left coronary artery may produce myocardial derangement, coronary perfusion should be continuous. Otherwise topical cardiac cooling or other means of myocardial protection should be used.

Adolescent↗
PubMed1977

Mechanodynamics at the interventricular sulcus--reciprocal effect of the ventricles on the ventricular function.

The forces acting on IVS were analyzed to delineate reciprocal effects of the two ventricles on the ventricular fucntion as a whole. The resultant force (FT) was dependent on the LV pressure but independent on the RV pressure. But the composite forces (F1 and F2) of FT were affected by the LV and RV pressures. In a normal heart F1 increased with increasing LV and/or RV pressures. But in F2 increase occurred only with increasing RV pressure. In the LV pressure increase occurred only when the RV pressure was 10 mmHg and decrease did when the RV pressure was 50 mmHg, while stable at 30 mmHg. Directions of both the forces (F1 and F2) diverged as the RV pressure increased and the LV pressure decreased. When FRV was hypertrophic, increases of the magnitudes of the forces were decreased when the pressures of the LV and RV were higher. The angle between the forces was also decreased so that the efficiency of the forces was risen. When a portion of the ventricles lost its contractility, FT increased, particularly, when FLV lost its contractility. But these increases seemed to well be within range of compensation.

Biomechanical Phenomena↗
PubMed1977

Pholipomycin, a new member of phosphoglycolipid antibiotics. II. Physico-chemical properties and comparison with other members of this family of antibiotics.

Physico-chemical characterization of pholipomycin revealed that this antibiotic is a new member of phosphoglycolipid antibiotics. Pholipomycin was differentiated from other members by the products formed on acid hydrolysis as follows: the presence of glucosamine, a 257 nm chromophore and moenocinol-type C25 lipids, but the absence of glucose, 6-deoxyglucosamine and glycine.

Ammonia↗