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Biomedical subjects

S Tanabe

Publications and source records attributed to S Tanabe.

At least 415 records · Page 23Linked to original sources
PubMed1980

Effect of zinc injection on Zn binding in cytosols of several tissues of kids.

1. An experiment was conducted with goat kids to determine the effect of zinc injection on Zn binding in cytosols of several tissues of kids. 2. Following the Zn load, plasma Zn increased for 8 h then decreased. Zn injection significantly increased the Zn contents of the liver and kidney. 3. Injection of Zn into kids stimulated the production of Zn in a fraction with an apparent molecular weight of approximately 10,000 in the cytosols of the liver, kidney and small intestinal mucosa. It is suggested that these fractions probably correspond to metallothioneins. Rumen papilla did not synthesize Zn-containing protein in response to an acute administration of Zn. 4. Zn injection significantly decreased the Cu content of the liver and affected the distribution of Cu in hepatic cytosol fraction, suggesting an interaction between these two elements. 5. The volume of bile collected in the gall bladder and its Zn content were markedly increased by Zn injection, suggesting that bile is one of the Zn excretion routes in kids.

Animals↗
PubMed1980

Identification of type A and type C virus particles in BF murine osteosarcoma.

Two types of virus particles, intracisternal type A and extracellular type C with budding, were detected in the same cells of BF osteosarcoma, its cultured cell lines, and their BFO tumors in CBA mice. The type C particles were approximately 100 microns in diameter. The buoyant density of the virions was 1.16g/ml in sucrose and 1.07 g/ml in Ficoll. A 72S RNA was demonstrated by gel electrophoresis, but no DNA was detected. Reverse transcriptase activity was also demonstrated in detergent-treated virions. Thus, the particles seem to be RNA virus. Cellular transformation and focus formation were observed after rat and mouse embryo cell monolayers were infected with the virus. The same kind of osteosarcoma was produced by inoculation of cloned transformed cells (BFOSV) of CBA embryo cells into CBA mice. Thus, the virus seems to be an oncornavirus.

Animals↗
PubMed1980

[Diagnosis of pituitary microadenoma by thin-section hypocycloidal tomography (author's transl)].

The authors stressed the reliability of lateral thin-section hypocycloidal tomography not only for the detection of pituitary microadenomas but also as an aid in surgical removal of them. Fourteen women with secondary amenorrhea were studied of which 13 cases showed high serum prolactin levels. Transsphenoidal surgery confirmed the presence of microadenomas less than 10 mm in all cases. The sellar volume measurement from plain radiographs of the skull was normal in all cases. The contour of the sella on plain lateral radiographs was abnormal in 4 cases (28.6%); double floor in 2 cases and localized ballooning in 2 cases. Hypocycloidal tomography was carried out at 2 mm intervals in both anteroposterior projection and lateral projection. Anteroposterior tomograms were abnormal in only 4 cases; each case with destruction of the sellar floor with small tumor shadow in the sphenoid sinus, central depression, lateral depression and sloping of the sellar floor. Lateral tomograms were, on the other hand, abnormal in all cases. Localized expansion with thinning in the anterior or anteroinferior portion of the sellar wall was found in 11 cases and the same finding in the inferior or inferoposterior portion of the sellar wall associated with thinning of the dorsum sellae was present in 3 cases. Lateral tomograms were considered more sensitive than anteroposterior tomograms from these results. We also studied the reliability of hypocycloidal tomography in the accurate localization of the tumor in comparing with the actual location of the tumor from the operative findings. In 12 cases the location of the tumor defined by hypocycloidal tomography was coincident with that by surgery. Moreover, when the sellar destruction was shown to be larger by hypocycloidal tomography, size of the tumor tended to be larger. These results suggested hypocycloidal tomography would be an accurate aid in surgical procedures.

Adenoma↗
PubMed1979

Chemotherapy of falciparum malaria: regional differences in responsiveness to treatment.

A review of chloroquine and sulfa-antifol combination treated falciparum malaria patients revealed a high incidence of chloroquine-resistance, wither R1 or R2, in patients infected in Southeast Asia or Oceania. In addition, more than one tenth of the patients infected in Laos or Thailand were resistant to sulfa-antifol combinations. Chloroquine-resistant cases were sensitive to sulfa-antifol combinations. On the other hand, while all patients treated in Tokyo who had been infected in Africa or Sri Lanka were sensitive to chloroquine, a field study suggested the presence of chloroquine-resistant P. falciparum in the area near Kaduna, Nigeria. One patient infected in Nigeria showed partial resistance to the MP (sulfamonomethoxine-pyrimethamine) combination, and another patient infected in the Central African Empire showed resistance to the MP combination, increasing from R1 to R3 within a short period. The incidence of resistance to sulfa-antifol combination therapy was high in the West African tropical region. The continent, county and area of infection should be taken in consideration when selecting antimalarial drug(s) for the treatment and suppression of falciparum malaria.

Adult↗
PubMed1978

Effect of age on C1q and C3 levels in human serum and their presence in colostrum.

The initiating complement component (C1q) in the classical pathway of 730 subjects and the first essential component (C3) in the alternative pathway of 461 subjects in Japan were examined. The study population consisted of normal healthy newborns, infants, children, adults and the old (from birth up to 75 years of age). In cord sera, both C1q and C3 were about 60% to the total mean level. At 3 days of age, C1q markedly increased to the mean level which remained relatively invariable up to 40 years of age. And above 40 years, the C1q level increased steadily with age up to about 75 years of age. C3 reached the mean level at about 1 month of age, and was highest during infancy. This level declined at about puberty and then continued to increase steadily with age up to around 55 years. In normal healthy subjects, a moderate positive rank correlation was found between C1q and C3 amounts. No significant differences of C1q and C3 levels were evident between male and female. No C1q was demonstrable in the colostrum from which lipids were previously removed, but after concentration by precipitation in a chelating agent with a low ionic strength, C1q, measured immunochemically, was detectable at concentrations of 300 ng/ml of colostrum. C3 was also detected at concentrations of about 200 microgram/ml of colostrum.

Adolescent↗