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Biomedical subjects

S Tamai

Publications and source records attributed to S Tamai.

At least 361 records · Page 20Linked to original sources
PubMed1981

Laryngeal carcinoid tumor: light and electron microscopic studies.

A case of laryngeal carcinoid in a Japanese 76-year-old man is reported. This neoplasm is extremely rare in the larynx and the case is the fourth so far reported in the world medical literature. Light and electron microscopic studies revealed argyrophilia and the presence of neurosecretory granules that had not been demonstrated in the previous cases. A review of the medical literature showed that all laryngeal carcinoids were pathologically malignant. The relationship of carcinoid tumor to oat cell carcinoma of the larynx is discussed, and the suggestion is made that a similar relationship exists between them as between carcinoid tumors and oat cell carcinomas of the lung.

Aged↗
PubMed1980

Pulmonary blastoma. An ultrastructural study of a case and its transplanted tumor in athymic nude mice.

A pulmonary blastoma in a 52-year-old Japanese man was serially transplanted into athymic nude mice. This report emphasizes the characteristics of the neoplasm seen on light and electron microscopic examination. The original tumor consisted of branching tubular structures and primitive mesenchymal components with a few smooth-muscle cell bundles, and resembled fetal lung tissue. Electron microscopic examination revealed that the immature stromal cells resembled epithelial cells. After serial passages in nude mice, the stromal element of the tumor disappeared, and the epithelial element showed squamous metaplasia and occasional mucus production. Endocrine-type granules were observed in a few tumor cells. Histogenetic considerations, including a suggestion that the tumor was derived from entodermal cells, are presented.

Animals↗
PubMed1980

Microvascular anastomosis with absorbable and nonabsorbable sutures--a comparative study in rats.

Polyglycolic acid, polypropylene, and nylon sutures were used to anastomose the aortas of 40 rats. Comparative studies of the healing process at the suture sites were performed. The long-term observations, by means of light and scanning electron microscopy, revealed that the regeneration of endothelium was more rapid and the endothelium had a smoother surface in the aortas that received the polyglycolic acid sutures than in the aortas receiving polypropylene or nylon sutures because the polyglycolic acid sutures were absorbed after 6 weeks. It was concluded that polyglycolic acid suture material may be more desirable than nonabsorbable suture material in microvascular anastomoses.

Anastomosis, Surgical↗
PubMed1980

Microsurgery in Japan.

Since the early 1960s microsurgery has been practiced by some of the pioneers in this country, and in the past decade it has given rise to a new era in the fields of reconstructive orthopedic surgery and plastic surgery, enabling repair of blood vessels and nerves, replantation of limbs and digits, and transfers of several composite tissues. A number of experiments and much clinical research in this field has been carried out by many Japanese microsurgeons, who contributed significantly to the development of microsurgery in the world. I have reviewed the history and the progress of microsurgery in Japan by introducing the important and interesting reports on this subject in chronologic order.

Animals↗
PubMed1980

Induction of squamous cell carcinoma in human bronchi transplanted into nude mice.

Segments of surgically resected human adult bronchi were xenotransplanted into the subcutaneous tissue of 35 BALB/c genetic background athymic nude mice with 3-methylcholanthrene placed in their lumina. Bronchial segments were removed 8 to 20 weeks after transplantation and preservation of the bronchial mucosa was confirmed in 26 segments. The most frequent change observed in the mucosa was goblet cell hyperplasia, followed by squamous metaplasia and dysplasia. Severe dysplasia or questionable squamous cell carcinoma in situ was noted at the site of the bronchial gland in a segment removed 8 weeks after transplantation, and invasive squamous cell carcinoma in a segment removed 15 weeks after transplantation. A difficulty in this work was the frequent earlier development of malignant tumors of mouse origin.

Adult↗
PubMed1979

Blood vessel transplantation to bone.

In dogs an artery, a vein, and a vascular bundle were transplanted into intact bone, isolated bone segments, necrotized bone, and homografts of bone. Active proliferation of new blood vessels and formation of new bone occurred in all instances where the vascular bundle was used, when the vein was implanted into the intact bone and isolated bone, and only when the artery was implanted into intact bone. As a result of these experiments, vascular bundle transplantation has been performed in patients with Kienboeck's disease, and avascular necrosis of the scaphoid, the femoral head, the talus, and other conditions.

Adult↗
PubMed1979

Small cell carcinoma of the lung and its histological origin. Report of a case.

A rare lung cancer consisting in part of small cell carcinoma of intermediate cell type and in part of well-differentiated papillotubular adenocarcinoma is described. Alcian blue-PAS staining was observed in the cytoplasm of the small cell carcinoma cells; the Grimelius argyrophil reaction was also positive in the cytoplasm of these cells. Electron microscopy revealed neurosecretory granules in the cytoplasm. At autopsy, a small cell carcinoma of intermediate cell type was found with both squamous features and gland formation. The cellularity and histological pattern of this tumor suggested the existence of a transitional pattern between small cell carcinoma of intermediate cell type, squamous cell carcinoma and adenocarcinoma. From the above findings, we think that small cell carcinoma including the intermediate cell type is derived from respiratory epithelial cells of endodermal origin with dedifferentiation of those cancer cells into neurosecretory cells.

Adenocarcinoma↗
PubMed1978

Digit replantation. Analysis of 163 replantations in an 11 year period.

From July 1965 to June 1976, 163 digits in 107 patients were replanted, and 145 digits survived-an 89 per cent success rate. Critical analyses were made of the causes of failures, complications, bone union, sensory recovery, secondary reconstructive procedures, and the final outcome. The majority of the patients were satisfied with their replanted digits, and no reamputation because of uselessness or causalgic pain of the replanted part has been necessary.

Adolescent↗
PubMed1978

Microvascular anastomosis and its application on the replantation of amputated digits and hands.

Successful microvascular anastomosis depends upon the applications of magnifications, special instruments and fine suture materials, and the surgeon's skill in the technique. The key points of one millimeter vessel anastomosis are the wall-to-wall coaptation of the vessel ends, the fewer number of interrupted stitches with relatively loose knot. To gain good coaptation, an oblique insertion of a needle through the vessel wall must be used. In a thin-walled vein repair, the lumen should always be kept open with frequent irrigations. Between July 1965 and December 1976, 150 digits out of 168 in 111 cases and 11 hands in 11 patients were successfully replanted. All tissues must be repaired primarily. The repair of artery is performed first, recirculation is allowed with systemic heparinization, followed by vein anastomosis. The rehabilitation is commenced from the first day. To gain good function, several reconstructive surgeries may be necessary on the replanted digit or hand.

Adolescent↗
PubMed1977

Traumatic amputation of digits: the fate of remaining blood. An experimental and clinical study.

Experimental studies on rabbit ears amputated by either a clean sharp division or severed by a crushing blow showed that twice as much blood remained in the crush group. Microthrombi and tissue thrombi were seen in this group only. A review of 142 digital replantations performed over a 10 year period showed 126 survivals. Ninety-three were complete amputations and 80 of these survived; 49 were incomplete amputations and 46 survived after revascularization attemps. Of 74 clear amputations, 68 survived; of 68 crush-type amputations, 58 survived. Circulatory disturbances occurred in 36 replanted digits; 16 could not be salvaged. The primary cause of complications was venous obstruction. In 80 digital replantations done from January, 1974, to December, 1975, success was obtained in 75 (93.75 percent). Irrigation of vessels of the severed part is done only in cases of double level amputation, severely crushed or those due to avulsion. Heparin, low molecular weight dextran, urokinase, and antibiotics are given for several days after operation.

Amputation, Traumatic↗
PubMed1977

Microsurgical replantation of a completely amputated penis and scrotum: case report.

A successful replantation of an amputated penis-scrotum, by microneurovascular anastomoses, is presented. There were no significant postoperative complications. A satisfactory result was obtained with sensory reinnervation of the glans. Microsurgical replantation, with anastomoses, is the best procedure in these cases when the circumstances permit it.

Adult↗