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Biomedical subjects

S Takeuchi

Publications and source records attributed to S Takeuchi.

At least 901 records · Page 50Linked to original sources
PubMed1979

Common protective antigen between Pseudomanas aeruginosa and Vibrio cholerae.

Immunization with a common antigen (OEP) of Pseudomonas aeruginosa produced a high level of protection in mice against Vibrio cholerae infection. The average OEP-HA titer in mice sera of immune group was 1,600 HA titer. However, vibriocidal titer and agglutinin titer against V. cholerae were not observed in sera of mice immunized with OEP. By passive administration of anti-OEP rabbit serum, mice were also protected against challenge with V. cholerae. In order to confirm the presence of the common antigen of P. aeruginosa in V. cholerae, IF-30 (common antigen of V. cholerae) was provided. Antibodies were found by the OEP-passive hemagglutination test to cross-react with the common antigen (OEP) of P. aeruginosa in sera of rabbits immunized with IF-30. The titer of OEP antibody formation in rabbits immunized with IF-30 was almost the same as that of P. aeruginosa. When mice were immunized with IF-30 and challenged with each of 7 kinds of Fisher's immunotype of P. aeruginosa, protection was observed in all the mice vaccinated against the challenge with each of the 7 kinds of strains. Furthermore, it was also confirmed that there was significant protection in mice injected with anti-IF-30 rabbit serum against all strains of Fisher's immunotype of P. aeruginosa.

Animals↗
PubMed1979

New surgical method for repair of anomalous left coronary artery from pulmonary artery.

A new surgical method for repair of anomalous origin of the left coronary artery from the pulmonary trunk is described. The principle of the proposed technique is to transmit the oxygenated blood to the anomalous left coronary artery through surgically created aortopulmonary window and the internal tunnel created in the main pulmonary trunk. A 2-year-old boy in whom this anomaly was associated with mitral regurgitation caused by papillary muscle dysfunction was successfully treated by this new surgical method, and the deformed mitral valve was concomitantly replaced by a Hancock porcine xenograft.

Angiocardiography↗
PubMed1979

[Treatment of Diphyllobothrium latum and Taenia saginata infections with aminosidine (author's transl)].

Recently, it has been known that the aminosidine has marked anthelmintic efficacy against tapeworm. In this investigation, aminosidine was used for treating 14 cases with Ciphyllobothrium latum infection and 5 cases with Taenia saginata infection. Aminosidine was administered orally in a single dose of 50 mg/kg, followed by a purge after the treatment. Fourteen patients with D. latum infection and 5 patients with T. saginata infection expelled long strobila in all cases. Although only 7 scolices of 18 worms of D. latum were found in the stool and no scolex of T. saginata was found, follow-up examination for a long period showed no evidence of remaining infection with one exception of D. latum. Mild nausea, vomiting and abdominal pain were observed in only one of 19 cases given aminosidine. But in the other 18 cases, no side effects were encountered. It was concluded that aminosidine is safe, effective therapeutic agent for the treatment of cestodiasis in man.

Adolescent↗
PubMed1978

Characteristic motor activity of the gastrointestinal tract in fasted conscious dogs measured by implanted force transducers.

Gastrointestinal contractile actiivity from the gastric body to the terminal ileum in conscious dogs was continuously recorded for several weeks by means of chronically implanted strain-gage force transducers. It was found that the 24-hr changes in the gastrointestinal contractile activity consisted of the two different major patterns, the digestive and interdigestive patterns. In the interdigestive state, a cyclic, recurring, caudad-moving band of strong contractions starting in the stomach and the duodenum and traversing the entire length of the small intestine was observed. When one band of strong contractions reached the distal ileum, another developed in the stomach and the duodenum again and propagated in a caudad direction. Such recycling episodes interrupted by long-lasting quiescence repeatedly occurred until the next meal. These characteristic contractile activities observed in our dogs are identical with the interdigestive myoelectric complex of the stomach and the small bowel recently reported by Code and Marlett (5). Four sequential phases (I-IV) of the migrating myoelectric complex, defined in terms of action potential activity, seem to correspond to the resting (quiescence), preceding irregular contractions, strong contractions, and subsiding contractions observed in the present study, respectively. Function and control mechanism of the interdigestive contractile activity were discussed.

Action Potentials↗
PubMed1978

Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs.

Simultaneous measurement of plasma motilin concentration and gastrointestinal contractile activity was make in 12 healthy dogs. Plasma motilin concentration was measured by radioimmunoassay and gastrointestinal contractile activity was monitored by means of chronically implanted force transducers. During the interdigestive state, it was found that the plasma motilin concentration increased in complete accordance with the cyclical interdigestive contractions of the stomach. Furthermore, plasma motilin concentration was lowered by the ingestion of food, and it reamined low as long as the gastric motor activity was in the digestive pattern. Since, as reported previously the interdigestive contractions can be induced by tthe exogenous administration of motilin, we concluded that (1) motilin is released at constant intervals during the interdigestive state, and this release is suppressed by the ingestion of food; (2) motilin induces the interdigestive contractions of the stomach and duodenum; and (3) motilin is an interdigestive hormone and is the only known polypeptide hormone of the gut whose release is not induced by a meal.

Animals↗