Search PubMed⌕ Search

Biomedical subjects

S Takeuchi

Publications and source records attributed to S Takeuchi.

At least 739 records · Page 41Linked to original sources
PubMed1984

The lateral thigh fascio-cutaneous flap in the repair of ischial and trochanteric defects.

We have recently designed and developed a lateral thigh fascio-cutaneous flap based on the first perforating artery. This artery supplies the distal part of the gluteus maximus muscle and continues to supply the fascia, subcutaneous tissues and skin over the lateral aspect of the thigh. We describe the use of this fascio-cutaneous flap in the repair of ischial and trochanteric defects.

Adult↗
PubMed1984

Manometric diagnosis of Hirschsprung's disease in the neonatal period.

A newly designed semiconductor manometer was assembled for anorectal manometry in the neonatal period. Sixty apparently healthy neonates and 17 patients who presented gastrointestinal obstructive symptoms were examined by the eighth day of life. All 60 apparently healthy neonates showed a normal fluctuating wave and rectoanal reflex. Prematurity and postnatal age do not influence the normal rectoanal reflex. Among 17 patients, 5 were diagnosed as having Hirschsprung's disease based on absence of the reflex. There were no false negative or false positive results among these cases. It appears that anorectal manometry could be a reliable diagnostic test of Hirschsprung's disease even in the neonatal period.

Anal Canal↗
PubMed1984

Molecular cloning and nucleotide sequence of DNA complementary to human decidual prolactin mRNA.

Three human decidual prolactin (PRL) cDNA clones (pdPL-1:349 base pairs, pdPL-2:584 base pairs, pdPL-3:807 base pairs without poly(A) tract) were prepared and sequenced. The insert DNA of the largest clone pdPL-3 contained the coding region corresponding to 217 amino acid residues including 18 amino acid residues of the signal peptide, and 157 nucleotides of the 3'-untranslated region. A comparison of the pdPL-3 cDNA sequence with that of human pituitary PRL cDNA revealed 4 silent nucleotide differences. Two of the base changes occurred in the third position of the amino acid codons, and the other two occurred in the 3'-untranslated region. Therefore, the amino acid sequence of decidual PRL deduced from the nucleotide sequence of pdPL-3 was identical with that of pituitary PRL. Minor changes were also observed among the three PRL mRNAs: a silent change in the third codon in the translated region, and another change in the 3'-untranslated region. Southern blot hybridization of human cellular DNA with the pdPL-3 probe indicates that PRL gene may occur once per haploid genome. Therefore, these minor changes may reflect microheterogeneity of PRL gene. The existence of multiple poly(A)-adjacent sequences was shown in the three species of human decidual PRL mRNA and in human pituitary PRL mRNA. This variation may be due to heterogeneity in the processing at the 3' terminus of mRNA or the termination sites of the transcription.

Amino Acid Sequence↗
PubMed1984

Transient neonatal hypothyroidism due to maternal immunoglobulins that inhibit thyrotropin-binding and post-receptor processes.

Transient neonatal hypothyroidism was found in a daughter of a 25-yr-old mother, who was receiving treatment for primary hypothyroidism due to Hashimoto's thyroiditis. During the neonatal period the infant had antithyroid microsomal and antithyroglobulin antibodies and TSH-receptor antibodies. The daughter recovered spontaneously from the hypothyroid state and the antithyroid antibodies disappeared from her serum. The mother's serum contained the same antibodies, and immunoglobulin G (IgG) from maternal serum blocked TSH binding to its receptors, TSH-stimulated cAMP responses, and cAMP-stimulated iodine uptake and organification in cultured thyroid cells. The latter finding suggests that the IgG had a postreceptor locus of action as well as inhibiting TSH binding to its receptor. The presence of such IgGs might have induced hypothyroidism both in the mother and in the daughter.

Adult↗
PubMed1984

Study of the posterior circulation in moyamoya disease. Clinical and neuroradiological evaluation.

Eighty-two cases of cerebrovascular moyamoya disease were studied by cerebral angiography and computerized tomography. Occlusive lesions were demonstrated not only in the anterior circulation but also in the posterior circulation, and they were associated with the development of an abnormal vascular network (moyamoya vessels). Although occlusive lesions do occur in the vertebrobasilar system, the vertebrobasilar system also acts as a source of collateral channels to the anterior circulation in this disease.

Arterial Occlusive Diseases↗
PubMed1984

[Combination chemotherapy with bleomycin, vinca alkaloid and cisplatin (BVP) for advanced urothelial cancer].

Since October 1979, 18 patients with metastatic urothelial cancer have been treated with combination chemotherapy of bleomycin (5-10 mg/day administered on days 1 to 7), vinca alkaloid (vinblastine 5-10 mg/day or vincristine 1 mg/sqm on days 8 and 9) and CDDP (60 mg/sqm on day 10). CR was achieved in 3 of the 18 patients and PR in 6 patients. Over-all, the response rate was 50%. Among 3 patients who achieved CR, 2 patients are still free of disease for 31 months and for 28 months, and the other is alive with cancer for 26 months. The 2-year survival rate was 58% in responders (CR + PR) and 0% in nonresponders. (p less than 0.005). In many cases, the response was observed after the first or second course of BVP therapy, and there was a relatively good response in patients with lymphnode metastasis alone. The treatment was tolerated well and common toxic effects were nausea, vomiting of moderate to severe degree (100%), myelosuppression (50%) and mild nephrotoxicity (22%). As to the choice of vinca alkaloids, vincristine seemed to be the treatment of choice because it was less toxic than vinblastine and was almost equally effective.

Aged↗
PubMed1984

[Adjuvant chemotherapy following total cystectomy for invasive bladder cancer with bleomycin, vincristine and methotrexate].

Eleven patients with invasive bladder cancer were treated with combination chemotherapy consisting of bleomycin (5 mg, i.m., day 1-7), vincristine (1 mg/sq.m.i.v., day 8) and methotrexate (200-300 mg/sq.m.i.v. day 8). Chemotherapy was started about 4 weeks following total cystectomy and repeated every 2 or 3 weeks at least for one year. Five of the patients were free of disease at the mean follow-up time of 35.6 months, ranging from 21 to 50 month. The 3-year survival rate was 54.5%. Bone marrow suppression (36%), nausea and vomiting (55%) were observed, but they were not serious and well tolerated. These results suggest that this regimen could be used safely as an adjuvant chemotherapy following total cystectomy for patients with invasive bladder cancer. Further evaluation will be necessary.

Adult↗
PubMed1984

[Clinical evaluation on the sensitivity test for anti-cancer agents in malignant bone and soft-tissue tumors].

We will report the result obtained from sensitivity tests on various anti-cancer agents for malignant bone and soft-tissue tumors based on SDI (Succinic Dehydrogenase Inhibition Test) method with the use of enzymic activities as marker since 1976. Our study comprised 27 cases altogether 15 cases of osteosarcoma, one case each of Ewing's sarcoma, malignant fibrous histiocytoma and malignant lymphoma, 3 cases of metastatic bone tumor and one case each of angiosarcoma, fibrosarcoma, rhabdomyosarcoma, liposarcoma, 2 cases of metastatic lung tumor among soft-tissue sarcomas. In all cases, sensitivity tests were done on the tumor tissues according to SDI method at the same time as biopsy for the determination of the appropriate medications. Four to six weeks of pre-operative intra-arterial infusion was done followed by radical operation. The results obtained are as follows. Observing the long-term results between subjects that applied anti-cancer agents decided by sensitivity test and those without sensitivity test. The 5 years cumulative survival rate jumped from 30.5% to 50.5%, showing a clear improvement.

Adolescent↗
PubMed1984

[HLA antigens in choriocarcinoma].

Choriocarcinoma can be regarded as transplanted cancer, because its origin is in trophoblast which is fetal tissue. It is of interest whether HLA antigens are expressed on choriocarcinoma cells or not, since HLA antigens may play an important role if the patient's body could recognize choriocarcinoma as "not self" and initiate its immune response. In this report choriocarcinoma tissue in the uterus, obtained after hysterectomy, is stained by an indirect immunofluorescence technique using monoclonal antibodies to HLA-A,B,C and HLA-DR. We believe this is the first immunohistological study in which choriocarcinoma in utero is available for study and monoclonal antibodies to HLA antigens are applied. In the staining of HLA-A,B,C, and of HLA-DR, host cells, such as myometrial cells, show positive staining but choriocarcinoma cells show negative staining. It is thought that choriocarcinoma cells are viable and show negative staining of HLA antigens, on the basis of finding following HE staining and hCG staining using anti-hCG antibody and the clinical remarks of the patient such as her high urinary hCG titer before operation and no history of chemotherapy. These results agree with those of previous studies about HLA antigens on choriocarcinoma cell lines.

Animals↗
PubMed1984

[A case of renal cell carcinoma in tuberous sclerosis followed by basic fetoprotein--a new carcinoembryonic protein].

There have been very few reports on renal malignancies in tuberous sclerosis and only 9 cases have been reported in the Japanese literature. A second case of renal cell carcinoma in tuberous sclerosis in Japan is reported. The present case is a 29-year-old male who visited our clinic with the chief complaint of right flank mass. The excretory urogram, and renal selective angiography suggested right benign renal tumor, possibly angiomyolipoma. But surgical exploration was performed because of the possibility of renal malignancy. The histological findings revealed renal cell carcinoma. At 18 months after operation, the patient died of multiple visceral metastasis, i.e., to lungs, left kidney and liver. In this case basic fetoprotein - a new carcinoembryonic protein - was measured and its level elevated gradually as the disease progressed. Judging from the measurement of basic fetoprotein in this patient it may be an efficient new tumor marker for renal cell carcinoma.

Adenocarcinoma↗