Search PubMed⌕ Search

Biomedical subjects

S Takeda

Publications and source records attributed to S Takeda.

At least 811 records · Page 45Linked to original sources
PubMed1985

[A case of Burkitt's lymphoma with total ophthalmoplegia].

Burkitt's lymphoma was first reported by Burkitt in 1958 as a sarcoma involving the jaw in African children with characteristic symptoms. Forty three Japanese cases have been reported since the first description by Oboshi et al. in 1969. We report a case of Burkitt's lymphoma with left total ophthalmoplegia. A 73-year-old Japanese female was admitted in Sadamoto Hospital on July 11, 1983 with a two-week history of headache, ptosis and double vision. The patient was exposed to the atomic bomb in Hiroshima and had ten-year history of hypertension. On admission, physical examination showed hypertension and neurological examination revealed only left total ophthalmoplegia (such as left ptosis, external ophthalmoplegia, mydriasis and deficit of light reflex). Plain X-ray film and enhanced CT scan showed no remarkable abnormalities. Laboratory examinations revealed high serum levels of GOT(51 K.U.) and LDH (1300 U.). Left carotid and right retrograde branchial angiograms showed no remarkable abnormal findings. While the patient was treated only conservatively, left abducent and trochleal nerve palsy appeared on August 5, 1983. On plain and enhanced CT scans at the time, abnormal density mass with bone destruction of the left sphenoidal sinus was demonstrated. Biopsy specimen from the left sphenoidal sinus showed lymphosarcomatous cells. Peripheral blood and bone marrow smears showed lymphoma cells which are compatible with L3-Burkitt's type according to FAB leukemia classification. The patient was diagnosed as leukemic transformation of Burkitt's lymphoma and treated with CHOP; Cyclophosphamide (C), Hydroxydaunorubicin(H), Vincristine (O), and Prednisolone (P).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1984

Direct effect of human growth hormone to inhibit glucose uptake in cultured human fibroblasts.

We have examined the effect of human growth hormone (HGH) on both basal and insulin stimulated glucose uptake in human fibroblasts. High concentrations of HGH (100 micrograms/mL) depressed both basal and insulin-stimulated glucose uptake by 25%. Significant inhibition was not seen at concentrations below 50 micrograms/mL of HGH. HGH-related hormones like human prolactin and ovine growth hormone had no effect on glucose uptake while high concentrations of ovine prolactin reduced basal glucose uptake, albeit to a lesser degree than HGH. In conclusion, high concentrations of HGH act independently of insulin to inhibit glucose uptake in human fibroblasts. These data may help explain the glucose imbalance and insulin resistance that is characteristic of acromegaly.

Adult↗
PubMed1984

Brain atrophy during aging: a quantitative study using computed tomography.

Using computed tomography, the authors studied brain atrophy during aging in 483 males and 497 females with no neurologic disturbances, ranging in age from 10 to 88 years. They measured cerebrospinal fluid (CSF) space volume and cranial cavity volume above the level of the tentorium cerebelli and calculated a brain atrophy index (BAI):BAI (%) = 100% X (CSF space volume/cranial cavity volume). Both CSF space volume and the BAI started to increase significantly after the thirties in both men and women (P less than 0.001). While the rate with which the brain atrophied accelerated constantly during aging in females, the rate of atrophy in men in their thirties and forties was more than twice that of women of the same age; the rate then declined in men in their forties and fifties. Both CSF space volume and the BAI increased exponentially with increasing age after the thirties, continuing to increase until the eighties in both men and women.

Adolescent↗
PubMed1984

Gallium induces reduction of negative charge of the cell membrane and redifferentiation of cancer cells.

In order to obtain an insight into the mechanism of experimentally induced redifferentiation of cancer cells, changes in negative charge of the cell membrane were examined by cytopherometry following in vitro exposure of the cancer cells to non-radioactive gallium. Reduction of the negative charge was observed at 24 hr and later. The gallium ions must have neutralized the negative charge of the cancer cell membrane to the normal range. This event may contribute in some way to cancer cell redifferentiation.

Adenocarcinoma↗
PubMed1984

Measurement of brain atrophy of aging using X-ray computed tomography: sex difference in 1045 normal cases.

We measured brain volume of 1,045 subjects with no brain damage using x-ray computed tomography and investigated brain atrophy of aging. Severity of brain atrophy was estimated by brain atrophy index (BAI): BAI (%) = 100 (%) X (cerebrospinal fluid space volume/cranial cavity volume). Atrophy of the brain began with statistical significance in the forties in both sexes. In males 40-49 years of age the mean BAI was 1.0% greater (p less than 0.001) and the S.D. of BAI was 1.1% greater (p less than 0.001) than those in their thirties. In females of 40-49 years the mean BAI was 0.5% greater (p less than 0.001) than that in their thirties, but there was no statistical significance between the two S.D.'s of both decades. The BAI increased exponentially with the increasing age from thirties in both sexes. Correlation coefficients were 0.702 (p less than 0.001, n = 471) in males and 0.721 (p less than 0.001, n = 480) in females. From the regression coefficients it was calculated that the BAI was doubled in 19.4 years in males and 17.4 years in females after thirties.

Adolescent↗
PubMed1984

Brain atrophy and cerebral infarction.

The subjects of the study (109 males, 48 females) were all diagnosed to have cerebral infarction by computerized tomography (CT). The cerebrospinal fluid (CSF) space volume and cranial cavity volume in the normal hemisphere of the patients were estimated using CT at the time from 1 to 3 weeks after the attack of cerebral infarction. The percentage of the CSF space volume to the cranial cavity volume was calculated as an indicator for brain atrophy and called brain atrophy index (BAI): BAI (%) = 100(%) X (CSF space volume/cranial cavity volume). The BAI immediately after the attack of infarction (6.6 +/- 2.2, n = 15), during which no detectable change occurred on CT examination, was the same as the BAI at the time from 1 to 332 days after the attack (6.6 +/- 2.4, n = 20). Therefore we compared the BAI in patients without infarction with the BAI in patients with infarction irrespective of secondary atrophy of the brain after the attack. The BAIs in males with infarction were significantly greater than the BAIs in males without infarction in the age of fifties, sixties and seventies. The BAIs in females with infarction were significantly greater than in females without infarction in the age of fifties, sixties and eighties.

Adult↗
PubMed1984

Occlusion of the great vein of Galen associated with a huge meningioma in the pineal region. Case report.

The authors report a case in which the great vein of Galen was occluded during removal of a huge meningioma in the pineal region. The patient recovered satisfactorily without any serious neurological deficits after the operation. Preoperative angiography had shown marked stenosis of the great vein of Galen and anastomoses between the deep and the superficial venous systems. Occlusion of the great vein of Galen may be well tolerated in particular cases if this vein is already compromised.

Adult↗
PubMed1984

[Topography of the serotonin neurons in the brain stem of human fetus: an immunohistochemical study].

The distribution of serotonin neurons in the central nervous system (CNS) has been intensively examined in mammals, such as rats, cats and monkeys. However, the details of serotonin neuron system have been remained uncertain in human CNS, although two fluorescence histochemical studies were reported in human fetus. In this study, we performed immunohistochemical examination on the distribution of serotonin neurons in the brain stem of human fetuses. The brain stems from five human fetuses (CRL: 120-275 mm, GA: 15-27 wks) were fixed with 4% paraformaldehyde, dehydrated with graded ethanol, and embedded in paraffin. Serial sections, 6 micron in thickness, were cut from seven different levels of the brain stem of each fetus. The initial several sections were used for usual histological observations. The following serial ones were stained by peroxidase-antiperoxidase (PAP) technique using anti-serotonin sera. The anti-serotonin sera used were raised in rabbits by the methods of Ranadive and Sehon (1967), Grota and Brown (1974), and Steinbusch et al (1978). Before the use, the specificity of the antisera was confirmed by the immunohistochemical examination of the CNS of rat embryos and adults. Positively stained serotonin neurons were clearly demonstrated in the brain stems of all cases examined (Figs. 1A-1H). They were small to medium in size, 10 X 20 micron to 20 X 40 micron, and varied in shape, showing round to oval cell somata with unipolar, bipolar and multipolar processes. The distribution of serotonin neurons in the brain stems was almost the same among five human fetuses (Figs. 2A-2K). A large number of serotonin neurons were located in the midline raphe nuclei. In addition, numerous serotonin neurons were observed widely in the other tegmental area. The nuclei containing serotonin neurons were listed in Table 2 according to the terminology by Olszewski and Baxter (1982). The distribution of the serotonin neurons in the raphe nuclei of human fetuses was fundamentally similar to those of many mammals reported previously. However, the lateral extension of serotonin neurons to the other tegmental area beyond the midline raphe nuclei in human fetuses was much greater than in any other mammals. This distribution pattern of serotonin neurons was considered to be peculiar to human fetus. Since the histological architecture of the brain stems of five fetuses examined was very similar to that of human adults, the distribution of serotonin neurons demonstrated here may also represent that of human adults.

Brain Mapping↗