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Biomedical subjects

S Takeda

Publications and source records attributed to S Takeda.

At least 739 records · Page 41Linked to original sources
PubMed1987

[A clinicopathological study of 108 consecutive primary hepatic malignancies in the University of Occupational and Environmental Health].

At our University, the rate of hepatic malignancies among the total number of those autopsied was shown to be higher than the mean rate of Japan. The 108 cases investigated included 92 hepatocellular carcinomas (HCCs), 10 cholangiocellular carcinomas (CCCs), 4 cases of combined HCC and CCC, one undifferentiated carcinoma, and one angiosarcoma. The positive rate of serum HBsAg among the HCCs in our series was almost equal to the mean rate of Japan. Twenty-eight HBsAg positive and 64 negative HCCs were clinicopathologically compared. The mean age at death was ten years younger for the positive cases than in the negative ones (p less than 0.05). However, there was no significant difference between both groups in any other biologic or pathologic feature, except for a few minor matters. We describe herein the summary of our cases with reference to a comparison study between HBsAg positive and negative HCC cases.

Adenocarcinoma↗
PubMed1987

[Effects of parathyroid hormone on the cardiovascular system].

It has been well accepted that the bone and kidney are the principal organs of parathyroid hormone (PTH) actions, but there has been little work on the cardiovascular system. We evaluated the effect of PTH on the cardiovascular system of rats. In thiobutabarbital anesthetized rats, synthetic bovine parathyroid hormone, containing the amino acid (b-PTH 1-34) in dose of 0.1-10 micrograms/kg iv, caused dose related decrease in mean arterial blood pressure (MAP). On the other hand, there were significantly increase in heart rate (HR) and left ventricular contractile force. With the doses of 10 micrograms/kg, PTH decreased the MAP from 104.3 to 55.5 mmHg, left ventricular pressure (LVP) 122.1 to 96.4 mmHg, left ventricular end diastolic pressure (LVEDP) from 6.70 to 6.37 mmHg and LV dp/dt max 5,684 to 4,736 mmHg/sec. The HR, LV dp/dt/p and Vmax increase from 399.7 to 410.0 bpm, 95.5 to 108.4/sec, 98.2 to 107.4/sec, respectively. The propranolol, phentolamine, atropine and promethazine did not affect these actions of PTH. On the basis of these findings, we conclude that PTH has the directory vasodepressive action and the effect of augmentation of the left ventricular contractile force.

Animals↗
PubMed1987

[Two cases of unresectable pancreatic cancer responding to combined chemotherapy with cisplatin, PSK and UFT].

Two patients who had unresectable pancreatic cancer were treated with a combined chemotherapy using Cisplatin, PSK and UFT. A remarkable decrease of tumor size was observed on CT. These two cases corresponded to partial response (PR) according to the response criteria proposed by Koyama-Saitoh. No significant side effects were observed during this therapy. From the results in these two cases, this combination chemotherapy was considered to be one of the most effective antineoplastic therapies available for pancreatic cancer.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[An autopsy case of myoclonus epilepsy associated with ragged-red fibers (Fukuhara disease)].

In 1980, Fukuhara et al. have reported two patients with "myoclonus epilepsy associated with ragged-red fibers" (MERRF), which is at present accepted as a distinctive clinical entity among the mitochondrial encephalomyopathies. We describe here postmortem findings of the case whose clinical findings were reported in detail by Fukuhara et al. (1980) as Case 1. The neuropathological findings were summarized as follows: 1) degeneration of dentate nucleus, red nucleus, globus pallidus, subthalamic nucleus and pontine tegmentum, 2) degeneration of the Clarke's column, spinocerebellar tract, posterior column and corticospinal tract, as well as of the posterior spinal nerve root and sural nerve, and 3) degeneration of substantia nigra, locus ceruleus, cerebellar cortex and inferior olivary nucleus. The lesions were degenerative in nature, and their distribution was different from those of dentato-rubropallidoluysian atrophy, Joseph's disease or Friedreich's ataxia. It was concluded that MERRF is a single disease entity also from pathological point of view.

Adult↗
PubMed1987

[A complete response in squamous cell carcinoma of the lung to combination chemotherapy by cisplatin and vindesine].

A 75-year-old male was admitted to our hospital for further investigation of a large mass shadow in the left hilum that was seen on an X-ray film of his chest. Cytological examination of his sputum revealed keratinized squamous cell carcinoma and combination chemotherapy using cisplatin and vindesine was administered. Later, both a chest X-ray and a CT scan showed a remarkable reduction in the size of the lung cancer. Complete response was obtained on the 90th hospital day, and was maintained with UFT administration. No sign of recurrence has been observed for over 9 months.

Aged↗
PubMed1987

[Clinical feature of male non-gonorrhoea urethritis and minocycline treatment of Chlamydia or Ureaplasma-infected urethritis].

Thirty-nine male patients with urethritis were studied for gonorrhoea or non-gonorrhoea infections. Only 2 patients were infected with N. gonorrhoeae, the other 37 patients were non-gonorrhoea urethritis (NGU). In 9 of these patients, C. trachomatis was identified and in 6 patients, U. urealyticum was isolated. No chlamydial urethritis was combined with ureaplasma. There was no clinical difference between chlamydia and ureaplasma infection, such as serous urethral discharge or mild pyuria. Minocycline was given orally at the dose of 200 mg daily for 7 to 42 days to these patients. Seven of the 9 patients (78%) with C. trachomatis and 7 of the 6 patients (67%) with U. urealyticum infection showed improvement of subjective and objective symptoms after minocycline. In no case, was an adverse reaction noted. Minocycline was effective in the treatment of both C. trachomatis and U. urealyticum urethral infection.

Adult↗
PubMed1987

[A case of double neoplasms--small cell carcinoma in the mediastinum and squamous cell carcinoma of the esophagus].

A 62-year-old Chinese man was admitted to our hospital because of dysphagia and hoarseness. Chest X-rays showed a superior mediastinal mass, and an operation for the removal of this mediastinal tumor was performed. The histological diagnosis indicated a small cell carcinoma, probably arising from the lung. He was readmitted to our clinic one year later with a complaint of dysphagia due to an esophageal cancer. Radical surgery for the esophageal cancer was performed, and the histological findings showed a well differentiated squamous cell carcinoma. The histogenesis of this carcinoma was considered to be independent of the earlier mediastinal tumor.

Adenocarcinoma↗
PubMed1987

[Liver abscess secondary to ventriculoperitoneal shunt].

Liver abscess is a rare complication following the ventriculoperitoneal (V-P) shunt operation. There has been only one case reported in the literature. We present a case of liver abscess developed about 3 months after V-P shunt operation. A 31-year-old female was admitted to our hospital in comatose condition due to second bleeding from an aneurysm of the right internal carotid artery on January 1, 1984. Obliteration of the aneurysm was performed on the following day. She received V-P shunt operation for the marked hydrocephalus on February 4, but she developed low spinal fluid pressure syndrome. She was able to walk by herself after the replacement of shunt valve on March 4. In the middle of April, she suffered from abdominal pain with a pyrexia for about 5 days. On May 13, a new peritoneal tube was placed in another part of the peritoneal cavity because of the recurrence of hydrocephalus. On the following day, she developed severe abdominal and back pains with a high fever. Abdominal CT scans and ultrasonogram were performed on May 22, showing a well-defined, cystic mass lesion in the liver and the peritoneal tube lying just beneath the mass lesion. Approximately 100 ml of white creamy pus was aspirated from the cystic mass by ultrasound-guided percutaneous puncture, and a 8.3 French pigtail nephrostomy catheter was left in place for 9 days until purulent drainage stopped. Microbiologic examination demonstrated staphylococcus epidermidis in the cerebrospinal fluid (CSF) from the shunt tube but was negative in the abscess fluid. The ventricular fluid was drained externally with the V-P shunt tube for a while, but the new ventricular drainage was instituted because of continuous positive cultures in the CSF from the shunt tube. Thereafter, the cultures of the CSF became negative and ventriculoatrial (V-A) shunt operation was performed on July 2. Postoperative course was uneventful. It is considered that the formation of the liver abscess seems to be caused by the focal injury to the liver surface by the insidiously infected peritoneal tube with St. epidermidis, and by the decrease in systemic resistance to infection. Percutaneous aspiration and drainage under the guidance of abdominal computed tomography or ultrasonography are very useful and efficient for the diagnosis and the treatment of liver abscess. When patients show signs of infection to the V-P shunt, we should remove the shunting system and place a new external ventricular drainage, and institute a V-A shunt after confirming negative cultures of the CSF.

Adult↗