[Use of picosulfate sodium in upper gastrointestinal examination].
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Biomedical subjects
Publications and source records attributed to S Tada.
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A 63-year-old male was admitted with a complaint of right abdominal mass. A right renal tumor associated with direct invasion to liver and with lobulated cystic lesion and renal solitary cyst were diagnosed preoperatively by aortography and computed tomography. Transperitoneal radical nephrectomy and partial resection of liver metastasis were performed. Histological diagnosis was clear cell carcinoma with dilated tubuli. Tumor invasion to the inferolateral portion of the liver and to the renal solitary cyst wall were demonstrated by both gross and microscopic examinations. The coexistence of tumor and cyst in the same kidney is rare. Our case probably had both the type I and II or III tumors according to Gibson classification. Twenty months after radical nephrectomy, pulmonary metastases were detected by chest x-ray, tomography and bronchial arteriography. All metastatic lesions were replaced by fibrous change 7 months after the four bronchial arterial infusions (BAI) of ADM 30 mg and irradiation with a dose of 5,000 rads to each lesion. After 9 tumor-free months, recurrence of pulmonary metastases were pointed out by chest x-ray and tomography. They (four coin lesions) were treated with anticancer therapy, mainly irradiation and twice insufficient BAI. Three of them were occupied entirely by fibrous change and another solid one remained in the right pulmonary apex without enlargement for the past 4 months. Radical nephrectomy and partial resection of the liver for the primary renal cell carcinoma with direct invasion to liver, BAI and irradiation for the two pulmonary metastases have kept the patient alive for 4 years.
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Urinary amikacin concentration was determined in 9 patients with severely unilateral ureteral obstruction. Serum levels were within the normal range. The average concentration of amikacin in the urine from obstructed urinary tract was 118.9 mcg/ml 6 hours after 100 mg amikacin iv infusion. Urine concentration from the normal kidney was 155.9 mcg/ml at the first 2 hours after intravenous infusion, 98.8 at the second 2 hours 83.3 at the third 2 hours. Urinary amikacin excretion from severely obstructed urinary tract was about one third of the total excretion from a normal system. In summary, the urinary level in severely obstructed urinary tract after iv infusion of 100 mg amikacin may be enough prophylactically. But at the onset of infection in severely obstructed urinary tract, the administration of at least 200 mg amikacin intravenously is required.
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We have clinically surveyed the distribution and disk sensitivity of bacterial strains obtained from urine of patients with various urological disease at our department during three (1975-1977) and four (1980-1983) years. Escherichia coli was the most frequently isolated (29.4%) from the outpatients, followed by Staphylococcus epidermidis (17.5%), Pseudomonas cepacia (11.2%) and Serratia marcescens (11.2%). Pseudomonas cepacia was the most frequently isolated (28.0%) from the inpatients, followed by Staphylococcus epidermidis (16.3%) and Serratia marcescens (15.9%). Pseudomonas cepacia which has been increasing was first isolated in 1977 and Serratia marcescens in 1976. They have become the main bacteria causing infections in our hospital. Pseudomonas cepacia was frequently isolated after postoperative prophylactic chemotherapy and Serratia marcescens in the late period of admission. The majority of Pseudomonas cepacia was resistant to all agents except chloramphenicol and doxycycline. Serratia marcescens was also resistant except to gentamicin and doxycycline. In Escherichia coli species, resistant strains increased gradually but they have good sensitivity to gentamicin, dibekacin, colistin and doxycycline. Staphylococcus epidermidis isolated from outpatients had good sensitivity to all agents but increased in incidence of resistant strains isolated from inpatients.
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