The cervicovaginal and endometrial isolation rates of Ureaplasma urealyticum and Mycoplasma hominis and relevant demographic data were obtained at the time of laparoscopy in 193 women from infertile marriage. For comparative purposes, fertile women undergoing laparoscopy for tubal ligation (n = 56) or other purposes (n = 64) were also cultured. Blacks were more likely than caucasians to be infected with either organism in all population types (p less than or equal to .05); however, no differences were noted in cervicovaginal carriage rates for blacks in different patient populations. M. hominis was isolated more frequently from tubal reanastomosis patients and less often from infertile patients, p less than or equal to .001. No differences were noted among the infertile subpopulations. Although the isolation rate of U. urealyticum from the different patient populations was similar, one subpopulation within the infertile population (male factor) was identified in which the prevalence of ureaplasmal infection of the female's lower genital tract was over twice as high (p less than or equal to .005) as in other infertile women. Yet there were no statistically significant differences in the demographic data of this subpopulation as compared to the population of infertile women as a whole. No other clinical subpopulation with single or multiple diagnoses not including male factor had an increased prevalence of infection. Eighty percent of infected, infertile couples had no clinical evidence of male factor infertility, indicating that only certain individuals are affected. This possibly explains why previous studies involving small numbers of patients without regard to clinical subpopulations have failed to show significant differences between infected and uninfected couples.(ABSTRACT TRUNCATED AT 250 WORDS)

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Interview with Sergio Stagno: Isolation precautions for patients with cytomegalovirus infection.

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Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fluid at 16-20 weeks of gestation: potential effect on outcome of pregnancy.

Samples from 61 amniotic fluids (33 discolored and 28 clear) collected by amniocentesis between 16 and 20 weeks gestation were cultured for microorganisms. Two of the discolored fluids were positive for Mycoplasma hominis, and two were positive for Ureaplasma urealyticum. Neither organism was isolated from samples of clear amniotic fluids. No other bacteria, viruses, or chlamydiae were isolated from fluids of any patient. The results prove that both M. hominis and U. urealyticum can infect the amnionic sac early in gestation without rupture of the fetal membranes. U. urealyticum was shown to cause a clinically silent, chronic (up to two months) intrauterine infection characterized by an intense inflammatory response. Complications in three of the four patients from whom mycoplasmas were isolated suggest, but do not prove, that mycoplasmal infection of amniotic fluid may have an adverse effect on outcome of pregnancy. Further studies are necessary to substantiate this implication and to determine the relationship between infection and discoloration of amniotic fluid.

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