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Biomedical subjects

S Silverman

Publications and source records attributed to S Silverman.

At least 199 records · Page 11Linked to original sources
PubMed1980

Craniofacial and central nervous system malformations induced by triamcinolone acetonide in nonhuman primates: I. General teratogenicity.

Eighteen pregnant Macaca mulatta, 15 Macaca radiata, and six Papio cynocephalus were treated with 5--20 mg/kg triamcinolone acetonide (TAC) between 21 and 43 days of gestation on single- or multiple-day treatment schedules. Prenatal deaths and stillbirths were tripled in the bonnet monkey and doubled in the rhesus monkey, but did not significantly increase in the baboon. The central nervous system and cranium were the most commonly malformed areas in all three species. The incidence of severe defects, e.g., cranium bifidum, encephalocele, meningocele, and hydrocephalus, was increased in multiple-day treated cases. Minor abnormalities such as aplasia cutis congenita, cranium bifidum occultum, and occipital lobe hypoplasia were more prevalent in single-day treated cases. The sensitive period (days 23--31) for TAC for this group of defects encompasses neural tube closure, rostral demarcation of the midbrain, and development of the primordial collicular plate and two midbrain neuromeres. The results of this study indicate that TAC is a valuable chemical tool for the study of malformations and pathogenesis of the brain and accompanying cranio-facial defects.

Abnormalities, Drug-Induced↗
PubMed1980

Histopathologic spectrum of oral erythema multiforme.

The histopathologic tissue patterns found in twenty-five patients with oral erythema multiforme were as variable as the clinical appearances. The biopsies served an important role in ruling out malignancy, dysplasia, and other classified diseases. While all of the specimens were designated as showing nonspecific inflammatory reactions, in many biopsy specimens there were sufficient characteristic connective tissue and epithelial changes to suggest a tissue diagnosis consistent with the clinical diagnosis of erythema multiforme.

Adult↗
PubMed1980

Dental xeroradiography as an adjunct in the evaluation of oral cancer: a preliminary report.

This pilot study of an experimental dental xeroradiography imaging system involved twelve oral cancer clinic patients. Xeroradiographs were compared with conventional intraoral film radiographs, taken with similar x-ray projections. The new dental xeroradiographic system was judged superior for the imaging of both osseous and soft-tissue structures. Especially significant was the new imaging system's ability to portray early bone erosion not detectable with the conventional intraoral film technique. These results point to the need for controlled clinical evaluations of dental xeroradiography, in order to assess the full potential of this rapid, low-radiation imaging system in the evaluation of oral cancer.

Bone Resorption↗
PubMed1980

Angiolymphoid hyperplasia with eosinophilia (Kimura's disease).

Angiolymphoid hyperplasia with eosinophilia (Kimura's disease) primarily affects the skin of the head and neck and the oral mucosa. While the clinical picture is nonspecific, the variable microscopic tissue pattern often is diagnostic. The etiology is unknown, and treatment is unpredictable. A case is presented in which Kumura's disease was not suspected clinically prior to the biopsy. The patient responded to topical fluocinonide, and there was no evidence of an immunologic defect.

Adolescent↗
PubMed1980

Topically applied fluocinonide in an adhesive base in the treatment of oral vesiculoerosive diseases.

Patients with oral vesiculoerosive diseases frequently require corticosteroid treatment to induce healing and reduce pain. Because of the adverse effects associated with systemic use, topical application of 0.05% fluocinonide in an adhesive base was investigated. The study group was comprised of 89 patients with erythema multiforme, lichen planus, benign mucous membrane pemphigoid, or pemphigus. In the double-blind phase involving 15 patients, seven responded completely and eight partially to the topical ointment. In the open study that included 74 patients, 35 had complete disappearance of signs and symptoms, while 39 experienced partial benefit. There were no adverse side effects. All 89 patients were observed for three to 35 months and each patient's condition continued to respond to the treatment when its use was required.

Administration, Topical↗
PubMed1980

Thoracic radiography of the normal rhesus macaque (Macaca mulatta).

Thoracic radiographs of rhesus macaques should be performed with short exposure times (1/60 s or faster) and the patient in the erect position. The patient's neck should be extended dorsally, and the arms extended above and behind the head. The tracheobronchial and lobar pulmonary anatomic features of the rhesus macaque are similar to those of the dog. The pulmonary parenchymal pattern also is similar; however, the interstitial markings are somewhat more prominent in the macaque. This may be due to lung mite infestation. The macaque does not appear from a radiologic standpoint to be superior as an animal model to dogs or cats unless there is something specific about the response or susceptibility to a disease being studied.

Animals↗
PubMed1979

The nucleotide sequence of a cloned Drosophila arginine tRNA gene and its in vitro transcription in Xenopus germinal vesicle extracts.

The DNA sequence of a cloned gene specifying Drosophila tRNA2Arg has been determined. Transcription of this gene in extracts from Xenopus germinal vesicles yielded a precursor RNA containing a seven-nucleotide leader sequence at the 5' side of the mature tRNA with pppGp as the 5'-terminal nucleotide. Transcription continues for at least eight nucleotides past the 3' terminus of the coding region of the gene and terminates over a stretch of seven T residues. The isolation of the primary transcript was facilitated by incorporation of 5'-(gamma-S)GTP into the 5' terminus of the precursor RNA and by its retention on mercury-agarose. The Drosophila tRNAArg gene does not contain an intervening sequence nor the C-C-A sequence corresponding to the 3' terminus of the mature tRNA. The nucleotide sequence of Drosophila tRNAArg formed in the in vitro system differs only in four positions from that of mouse tRNAArg.

Animals↗
PubMed1979

Oral cancer and herpes simplex virus--a review.

Numerous studies have suggested that patients with oral cancer have an increased immune response to herpes simplex virus. However, the number of cases has always been small, and essential controls have not always been included. Laboratory experiments have shown that herpes simplex virus can be carcinogenic or cocarcinogenic under certain circumstances and so must be considered as a possible etiologic agent in oral cancer. This article reviews past research and suggests priorities for future investigations.

Antigens, Neoplasm↗
PubMed1979

The nucleotide sequence of the initiator tRNA from Drosophila melanogaster.

The nucleotide sequence of Drosophila melanogaster methionine tRNAi was determined to be: pA-G-C-A-G-A-G-U-m1G-m2G-C-G-C-A-G-U-G-G-A-A-G-C-G-U-m2G-C-U-G-G-G-C-C-C-A-U-t6A-A-C-C-C-A-G-A-G-m7G-D-m5C-C-C-G-A-G-G-A-U-C-G-m1A-A-A-C-C-U-U-G-C-U-C-U-G-C-U-A-C-C-A(OH). It differs from vertebrate initiator tRNAs in only 6 out of 75 positions.

Animals↗
PubMed1979

The nucleotide sequence of lysine tRNA2 from Drosophila.

The nucleotide sequence of Drosophila melanogaster lysine tRNA2 was determined to be: pG-C-C-C-G-G-C-U-A-m2G-C-U-C-A-G-D-C-G-G-D-A-G-A-G-C-A-psi-G-A-G-A-C-U-C-U-U-t6A-A-psi-C-U-C-A-G-G-m7G-D-C-G-U-G-G-G-Xm-U-C-G-m1A-G-C-C-C-C-A-C-G-U-U-G-G-G-C-G-C-C-A(OH). With minor differences in the state of modification of some nucleotides, the sequence is the same as that of lysine tRNA2b from rabbit liver.

Animals↗
PubMed1979

Study of a bland dentifrice for persons with radiation-induced mucositis and vesiculo-erosive disease.

Althought the patient group was limited to persons with radiation-induced mucositis, lichen planus, and erythema multiforme, the study indicates the potential usefulness of a bland dentifrice to other patients with sensitive mouths. Although it is presumed that regular brushing habits will aid in oral hygiene and health, the specific effect of a bland dentifrice on control of plaque, caries, and periodontal disease cannot be assessed in this preliminary study. Also, no comparison was made with cleaning techniques in which dentifrice is not used. Therefore, this study indicated only that dentifrice with reduced flavor, like the one used in this study, may encourage better oral hygiene through continued brushing when irritation from regular dentifrices discouages it.

Adult↗