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S Shinagawa

Publications and source records attributed to S Shinagawa.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Clinico-pathological analysis of stage IIIa carcinoma of the cervix uteri].

We have reviewed cervical carcinoma IIIa cases treated at the University of Hirosaki Hospital from 1970 to 1984 and at the Metropolitan Komagome Hospital from 1975 to 1984. In this period, 32 cases were staged at IIIa, and this group accounts for less than 2% of all cervical cancer cases at these two institutions. The age of the 32 patients ranged from 33 to 86 years with a mean age of 66. In treatment methods, 3 cases were operated on and other cases were irradiated by a combination of intracavitary therapy and external beam therapy. The actuarial 5-year survival rate was 78.3%, and the relative 5-year survival rate was 86%. Our results suggest that FIGO stage IIIa carcinoma of the cervix has a much better prognosis than FIGO stage IIIb cervical cancer.

Adult↗
PubMed1986

[Clinical value of urinary kallikrein determination in obstetrics].

Whether to determine the urinary kallikrein (UKK) level in the second trimester of pregnancy is valuable or not for the prediction of gestosis, especially of hypertension in the third trimester of pregnancy, was studied on 700 cases of pregnant women including 50 cases of gestosis. The main results obtained were as follows. Sixty cases of 610 non-gestotic women were low in UKK, and 17 of these cases later resulted in gestosis or preterm delivery. When a patient with mild gestosis and/or hypertension was admitted, the UKK level was elevated significantly in general by bed rest and a low-salt diet. The UKK level was more significantly lowered in threatened preterm delivery than in normal pregnant women (p less than 0.001). A close positive correlation was seen between UKK levels and prostaglandin E2 in urine in pregnant women (n = 30, r = 0.528). A relatively close correlation was seen between UKK levels and roll-over test results (n = 30). From these results, the authors reached the conclusion that to determine UKK in the second trimester of pregnancy is quite valuable in predicting not only gestosis and/or hypertension in the third trimester of pregnancy but also preterm delivery.

Adult↗
PubMed1985

Emeriamine, an antidiabetic beta-aminobetaine derived from a novel fungal metabolite.

Emeriamine [(R)-3-amino-4-trimethylaminobutyric acid], derived from a novel fungal metabolite "emericedin" [(R)-3-acetylamino-4-trimethylaminobutyric acid], was proved to be a strong and specific inhibitor of carnitine-dependent oxidation of long chain fatty acid (IC50; 3.2 X 10(-6)M) and its main inhibition site was shown to be carnitine palmitoyltransferase I located on the outer-surface of the mitochondrial inner membrane. Emeriamine also showed hypoglycemic and antiketogenic activities in a dose-dependent manner (1 - 10 mg/kg) when administered orally to fasted normal and diabetic animals.

Acyltransferases↗
PubMed1985

Isolation and characterization of bulgecins, new bacterial metabolites with bulge-inducing activity.

Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with beta-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic compounds containing a sulfate group in the molecule. Acid hydrolysis showed that D-glucosamine and a new proline derivative are common constituents of the three components. In addition, taurine and beta-alanine are constituents of bulgecins A and B, respectively.

Glucosamine↗
PubMed1985

[Urinary kallikrein levels during pregnancy].

Whether to determine the urinary kallikrein (UKK) levels in the second trimester of pregnancy is valuable in predicting of gestosis, especially of hypertension, was studied using samples of urine obtained from 500 cases of pregnant women without gestosis, 50 pregnant women with gestosis and 50 cases of pregnancy with a variety of complications other than gestosis. The main results obtained were as follows: In normal pregnancy, UKK levels elevated with pregnancy for a peak in the first to the second trimester of pregnancy, tapering off thereafter. The UKK level was significantly lower in 20 pregnant women with gestosis especially in hypertensive type than in pregnant women without gestosis (p less than 0.001). Pregnant women with normal blood pressure who suffered no gestosis and had an extremely low UKK level, accounted for 9.8% of all pregnant women studied. This figure includes a large number of those who were in a high risk group for the onset of gestosis. From these findings, UKK was considered to be useful as one of the factors used in predicting the onset of hypertension in association with gestosis and we are now studying pregnant women in the 20th and 30th week of pregnancy in more detail.

Female↗
PubMed1985

Type and screen system for elective surgery in obstetrics and gynecology.

In June, 1983, a preoperative blood ordering policy of "type and screen" was introduced in our department for elective surgery. Using this system, sera are preoperatively tested for unexpected antibodies and ABO/Rh typing is done. If the antibody screen result is negative, crossmatching is not done preoperatively. This paper reports our experience with the type and screen system in obstetrical and gynecological practice, and documents its safety, usefulness and efficiency. By adopting this system, the overall ratio of crossmatch to transfusion (C/T)-declined from 8.96 to 1.84. There were 3 patients in this series of 80 (3.75%) with a positive antibody screen result. No untoward reactions were observed following transfusion. Based on these results, the type and screen system for preoperative blood ordering is recommended for most of routine obstetrical and gynecological procedures.

Blood Group Antigens↗
PubMed1984

Significance of positive direct anti-globulin test for cord blood--in administration of anti-d immunoglobulin for postpartum immunoprophylaxis.

The aim of this paper is to reconsider the significance of a positive direct antiglobulin test for cord blood, especially in the case of administration of anti-D immunoglobulin for postpartum immunoprophylaxis. In 421 samples of cord blood, 14(3.3%) positive results were obtained in a direct antiglobulin test. From these cord blood cells, antibodies were eluted and identified as follows: anti-A, 6; anti-B, 6; anti-E+ c, 1 and anti-Jra, 1. Thus, not all cases giving positive results in a direct antiglobulin test in cord blood at delivery have anti-D antibodies. And the elution test should be done in order to specifically identify the coated antibody as anti-D or non-anti-D.

ABO Blood-Group System↗
PubMed1984

Fibrinogen and its fraction during pregnancy and puerperium.

A study involving the determination of total fibrinogen and high molecular weight (HMW) fibrinogen was performed with the glycine precipitation method. Ninety patients in different trimesters of pregnancy and 37 non-pregnant controls participated in the study. Total fibrinogen was found to increase during pregnancy until delivery, after which it declined gradually, peaking once more on the 3rd day of puerperium. HMW fibrinogen showed a similar pattern during pregnancy and puerperium, but markedly increased at the time of delivery. These elevated values during pregnancy indicate a significant change in the fibrinolytic system, which is believed to be depressed during pregnancy, enhanced during the postpartum period, and stabilized after the 3rd day of puerperium.

Adult↗
PubMed1984

Gynecological malignancies and disseminated intravascular coagulation.

The importance of DIC in the management of gynecological malignancy, especially in advanced cases, was stressed on the basis of our experience with 8 cases. The overall incidence of DIC in our series of 366 cases of gynecological malignancies was 2.2%. However, DIC was experienced only in cases of advanced later stages and the recurrence of malignancy, and the incidence of DIC in these two groups were 2.2% and 7.2% respectively. In our 8 cases, DIC seemed to be provoked or worsened by antitumoric chemotherapy, major surgery, radiation therapy, infection, cerebral infarction and massive packed red cell transfusion. At the same time, an exceptional case of fulminating DIC which had probably been provoked by packed red cell transfusion in a patient with advanced but not detected endometrial cancer which developed in a endometriotic uterus was presented.

Adult↗
PubMed1984

Clinical usefulness of terbutaline in the management of placenta praevia.

Terbutaline was given to five patients with complete placenta praevia in order to prevent massive bleeding while at the same time prolonging the pregnancy. The longest period gained on therapy was 48 days and the shortest was 6 days. Doses of terbutaline used in these periods were 0.71-4.47 mg/dl. No serious complications were observed.

Adult↗
PubMed1984

Systolic time intervals and impedance cardiogram in pregnant and toxemic women.

STI measurements and impedance cardiography were carried out during gestation and post partum in 231 cases. In normal pregnant women, prolongation of the Q-I interval, isometric contraction time (ICT), preejection period (PEP) and shortening both of the Q-II interval and ejection time (ET) were all marked in late stages of pregnancy. Mean values for stroke volume (SV), cardiac output (CO) and cardiac index (CI) were at the maximum at 16-23 weeks of pregnancy, and then fell in the antepartum period. The total peripheral resistance (TPR) at 16-23 weeks of pregnancy was lower than in other periods. In the postpartum period, the heart rate was lowered, and the Q-II interval and ICT were prolonged. In toxemic pregnancy, SV, CO and CI were lower than those of the normal group and various changes in STI were more apparent than those of non-toxemic pregnants in the supine position. By the postural change from supine to left lateral in toxemia, the improvement in STI was not as good as in the normal pregnant group and, moreover, SV and CO were decreased and TPR was increased. These results suggest that in toxemic pregnancy the left ventricle might be less complaint and less sensitive to the increase in venous return.

Adult↗
PubMed1983

[4,4'-D-diaminopropionic acid]gramicidin S: a synthetic gramicidin S analog with antimicrobial activity against Gram-negative bacteria.

Gramicidin S is especially active against Gram-positive bacteria; e.g., Staphylococcus aureus. An analog, [4,4'-D-diaminopropionic acid]gramicidin S, which contains D-diaminopropionic acid residues instead of D-phenylalanine residues, has been synthesized. This analog is active against some of the Gram-negative bacteria; e.g., Escherichia coli and Salmonella typhosa. Activities of several related analogs are discussed.

Bacteria↗
PubMed1983

Foetal head growth retardation due to antiepileptic drugs: with reference to GH, TSH, T4, T3 and reverse T3 concentrations.

To study the mechanisms of inhibitory action of antiepileptic drugs on foetal head growth, determinations were made of the growth hormone, thyrotropin and thyroid hormone levels in the sera of pregnant women, and the correlations between each hormone concentration and the foetal head circumference were studied. The thyroxine level decreased in the maternal serum and in the cord blood, and the thyrotropin level also became lower in the epileptic mother taking antiepileptic drugs. The growth hormone level in the umbilical vein sample of the epileptic mother was lower than that in the controls. The correlations between the head circumference of an infant at delivery and the decreased levels of the hormones seemed to indicate that a decrease in the thyroxine level, caused by antiepileptic drugs, produced the foetal head growth retardation.

Adult↗
PubMed1983

A study on proteins contained in urine of gestosis patients.

Immunologic analyses of urinary proteins in patients with gestosis and related obstetrical conditions were performed and urinary protein patterns were compared with blood plasma protein patterns. Many kinds of proteins could be detected in urine of patients with gestosis beside albumin. Therefore, "proteinuria" should be chosen to characterise this state instead of the term "albuminuria". Generally speaking, when a total volume of protein contained in urine increases, its types or subfractions also increase in urine. Next to albumin, the most commonly detected proteins in urine of patients with gestosis were transferrin, IgG, inter-alpha-trypsin inhibitor, alpha 1-antitrypsin, IgA, alpha 2-HS-glycoprotein, alpha 1-acid glycoprotein, Gc-globulin, alpha 1-antichymotrypsin, hemopexin, ceruloplasmin, prealbumin, haptoglobin, anti-thrombin III, Cl-inactivator, IgM, and alpha 2-macroglobulin, in the descending order of their occurrence. Proteins that promptly became negative in urine of gestosis patients after delivery were inter-alpha-trypsin inhibitor, IgA, and ceruloplasmin. On the other hand, proteins most apt to persist in urine were albumin, alpha 2-HS-glycoprotein, and IgG. Generally speaking, lower molecular weight proteins were likely to persist in urine after delivery. Simultaneous determination of blood plasma and urinary proteins was performed for 18 kinds or subfractions of protein. A prognostic value of renal protein clearance was discussed.

Abruptio Placentae↗
PubMed1983

Management of twin pregnancy--for the prevention of preterm delivery.

From a retrospective analysis of 38 consecutive cases of twins the authors have reached a conclusion that in the management of twins the following policy is applicable: 1. For every pregnancy, a routine ultrasonic examination should be done for the detection of twin earlier than 20 weeks of gestation. 2. Elective hospitalization or bed rest at home should be advised from a period of 30 weeks of gestation. 3. After 32 weeks of gestation, an increased antenatal assessment (including serial ultrasonography) and biophysical monitoring (such as simultaneous NST) should be done.

Female↗