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Biomedical subjects

S Sehgal

Publications and source records attributed to S Sehgal.

At least 181 records · Page 10Linked to original sources
PubMed1987

Cold reactive lymphocytotoxic antibodies in patients with tuberculoid and lepromatous leprosy.

Fifty-seven sera from leprosy patients and 33 sera from age- and sex-matched hospital controls were tested for the presence of cold-reacting lymphocytotoxic antibodies (LCAs) at 15 degrees C against a panel of 30 HLA-typed normal lymphocytes. Eighteen of 57 (31.6%) leprosy sera and 22 of 33 (67%) control sera showed reactivity, but the strength of reactivity of the patients' sera was significantly more than that of the control group (p less than 0.01 by Wilcoxon rank sum test). Within the leprosy group, there was no significant difference in the reactivity of 30 tuberculoid and 27 lepromatous sera. The occurrence of LCAs was independent of the sex or the HBsAg status of the serum donor. LCA activity was not correlated with treatment status, bacillary load, or reaction state.

Antilymphocyte Serum↗
PubMed1986

Extramedullary plasma cell tumors: diagnosis by fine-needle aspiration cytology.

Nine cases of plasma cell tumors were diagnosed by fine-needle aspiration cytology, the sites of aspiration being soft-tissue swellings in five cases, lymph nodes in three cases, and both soft-tissue swelling and lymph node in one case. The age of the patients ranged from 33 to 74 yrs, with a median of 52 yrs. Only three of these nine cases were clinically diagnosed as multiple myeloma. Unequivocal demonstration of myeloma cells was possible in eight cases. The smear in ninth case showed mostly undifferentiated blast cells with a few cells showing plasmacytoid differentiation. Giant myeloma cells with monstrous segmented nuclei were encountered in two cases. M-component could be demonstrated in serum and/or urine samples in all seven cases in which it was sought.

Adult↗
PubMed1986

Neurological complications of acute haemorrhagic conjunctivitis.

Forty four cases of the neurological complications of acute haemorrhagic conjunctivitis (AHC) seen in India during 1981 epidemic are reported. The disease predominantly affected adult males. The preceding attack of AHC, a latent period, prodromal symptoms of fever, myalgia and root pains followed by acute onset of lower motor neurone paralysis of limbs and/or cranial nerves formed the classical picture of neurological involvement. The recovery was poor and nearly half of the patients remained severely handicapped. Electrophysiological studies showed early appearance of widespread fibrillations and fasciculations, large polyphasic potentials of increased amplitude and reduced interference pattern. Nerve conduction studies were normal in most of the cases. Cerebrospinal fluid (CSF) examination revealed lymphocytic pleocytosis and rise in protein content. Significant antibody titres against enterovirus type 70 (EV 70) were demonstrated in the serum and the CSF. HLA studies showed low occurrence of A2 and B15 HLA antigens. Muscle biopsies revealed neurogenic atrophy and sural nerve biopsies were histologically unremarkable. The similarities of this disease with poliomyelitis and its pathogenesis are discussed.

Adolescent↗
PubMed1986

HLA antigens in schizophrenia: a family study.

HLA haplotypes A and B were studied in eight families with two or more schizophrenic members. All index cases and all but two sick relatives satisfied Research Diagnostic Criteria for the diagnosis of schizophrenia; 45 subjects were studied. Data were analysed by sequential tests for the detection of linkage and by the affected sib-pair method. The results do not support a linkage between HLA and schizophrenia.

Female↗