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Biomedical subjects

S Schubert

Publications and source records attributed to S Schubert.

122 records · Page 7Linked to original sources
PubMed1981

[Problems in the differential diagnosis of intestinal diseases in patients who have traveled in the tropics].

Taking into consideration the increasing intercontinental tourist traffic we are in an increasing degree confronted with diseases which above all or exclusively acquired in warm countries. Besides the diseases which occur in our country they must find differential diagnostic consideration in disturbances of the health. On account of their frequency gastrointestinal disturbances they are essential for these travellers. On the basis of the following instances of diseases problems of the differential diagnosis and the evaluation of findings are shortly demonstrated: colon amoeboma; colon carcinoma; colon polyposis; ascaridasis; lambliasis; trichuriasis, affection with fasciola hepatica; affection with fasciolopsis buski; schistosomiasis intestinalis. It is referred to peculiarities in inhabitants of the tropics who transitorily live in our climatic zone.

Colonic Diseases↗
PubMed1979

[Possible pathogenetic factors of gallstone formation in populations with a high standard of living (author's transl)].

The present work points out the variety of conditions favouring gallstone formation.--Recent research suggests that fibre-depleted, high-fat foods may lead to cholesterol gallstone formation in man. On the other side civilized diets contribute to the carcinogenesis of large bowel.--Experimental observations have indicated that hypovitaminosis C may favour pathogenesis of these diseases in a different way.

Ascorbic Acid Deficiency↗
PubMed1975

[Hyperlipoproteinemias in diabetes mellitus].

Among 200 diabetics 63 patients (31.5%) with primary and 44 patients (22%) with secondary hyperlipoproteinaemias were found. The secondary hyperlipoproteinaemias belonged to the types IV and V, the primary hyperkipoproteinaemias to the types IIa, IIb, IV and V. In primary hypercholesterolaemias (IIa, IIb) the retinopathia diabetica by far more frequently occurs than in primary hypertriglyceridaemias.

Diabetes Complications↗
PubMedDate not supplied

Influence of Ly146032 on chemotaxis, chemiluminescence of PMN and lymphocyte transformation in vitro.

The influence of Ly146032, a new acidic lipopeptide, on chemotaxis, luminol-dependent chemiluminescence of human polymorphonuclear leukocytes (PMN) and phythemagglutinin induced lymphocyte transformation of murine cells was investigated. At therapeutic range there was no remarkable effect on the parameters tested. Incubation with more than 20 mg/l Ly146032 was followed by depression of chemiluminescence, whilst transformation of maximally PHA stimulated lymphocytes was suppressed by more than 32 mg/l Ly146032.

Anti-Bacterial Agents↗
PubMedDate not supplied

Quantitative analysis of paradoxical interventricular septal motion following corrective surgery of tetralogy of fallot.

This study aimed to quantify paradoxical interventricular septal motion (PSM) among 20 patients following tetralogy of Fallot (TOF) repair without severe pulmonary regurgitation and 20 age-matched normal subjects. PSM was quantified using the echocardiography-derived paradox index. Tissue Doppler-derived strain rate was used to assess the longitudinal and radial systolic function of the interventricular septum (IVS). The tissue Doppler-derived Tei index was used to assess the global left ventricular function. Compared to the control group, the paradox index in patients after repair of TOF was significantly higher (p = 0.001), whereas the regional IVS longitudinal (p = 0.02) and radial (p = 0.001) systolic strain rate peaks were significantly reduced. The paradox index in the patient group correlated inversely with the IVS radial peak systolic strain rate (r = -0.64, p = 0.004) and positively with QRS duration (r = 0.50, p = 0.02). The left ventricular (LV) Tei-index correlated significantly with the paradox index (r = 0.71, p = 0.001) and with the septal radial systolic strain rate peak (r = 0.59, p = 0.004). We conclude that electrical delay and reduced regional septal systolic function were the main causes for paradoxical septal motion among patients following TOF repair without significant pulmonary regurgitation. The reduced LV systolic function among this group of patients is mainly secondary to diminished septal systolic function and the paradoxical septal motion.

Adolescent↗
PubMedDate not supplied

Comparison of the tissue Doppler-derived left ventricular Tei index to that obtained by pulse Doppler in patients with congenital and acquired heart disease.

We compared the left ventricular Tei index measured by tissue Doppler imaging (TDI) to that obtained by pulsed Doppler (PW) in patients with congenital heart disease. In 40 consecutive patients with a variety of congenital and acquired heart diseases, the left ventricular (LV) PW Doppler-derived Tei index was assessed on-line as previously described. TDI-derived anatomic curved M-mode and the unprocessed velocity trace from the basal septum were used to time the opening and closure of the mitral and aortic valves in one cardiac cycle, respectively. The TDI Tei index was calculated off-line according to the equation (isovolumetric relaxation time + isovolumetric contraction time)/ ejection time. The Tei index calculated from TDI correlated significantly with that measured by pulsed Doppler (r = 0.92, p = 0.001). The mean difference (range) between pulsed Doppler-derived Tei index and TDI-derived Tei index was 0.005 (-0.07-0.06), which was within the limits of agreements. Interobserver variability for the TDI-derived Tei index was 5 +/- 3%. The TDI Tei index can be used to assess the global LV function in patients with congenital heart disease. In contrast to the PW Doppler-derived Tei index, the TDI-derived Tei index obtained from the same cardiac cycle may help to differentiate systolic from diastolic dysfunction by providing specific information on the isovolumetric intervals.

Adolescent↗
PubMedDate not supplied

[Reliability and validity of the upper limb DASH questionnaire in patients with distal radius fractures].

AIM: The purpose of the study was to verify test criteria of the upper-limb DASH questionnaire in patients with Colles' fractures. METHODS: 107 of 139 patients with Colles' fractures treated operatively were examined and asked to complete the questionnaire. To establish reliability, the item answers of all questionnaires were analysed by using Cronbach's Alpha correlation coefficient and corrected item total correlation. Construct validity was evaluated by comparing the DASH points with clinical measures according to Gartland/Werley and Castaing (Spearman correlation coefficient). Discriminant validity was assessed by comparing the DASH points of patients with AO-type A/B fractures and AO-type C fractures (Mann-Whitney U-Test). RESULTS: 2.7 percent of all questionnaires were unusuable. The time to fill out the questionnaire was on average 12 minutes. Cronbach's alpha values were high in all scales (alpha > 0.8). No items were found unsuitable (corrected item total correlation > 0.5 in 28 of 30 questions). DASH scores were correlated with ROM deficits and clinical measures of wrist function (r = 0.53; r = 0.59; r = 0.52, p < 0.01). The questionnaire could discriminate patients with different fracture types (p < 0.05). CONCLUSIONS: DASH is a workable, reliable and valid instrument for patients with Colles' fractures.

Adolescent↗
PubMedDate not supplied

[L-tryptophan-associated chronic eosinophilia-myalgia syndrome treated with cyclosporin].

After 2 weeks of ingestion of 130 g L-Tryptophan a 52 year old female develops an Eosinophilia Myalgia Syndrome with acute onset of deep venous thrombosis of forearm and possible initial cardiac manifestation featuring intermittent sinustachykardia. This is followed by a severe chronic disease (follow-up 15 months) with diffuse scleroderma and sensomotoric polyneuropathia. The deep muscle biopsy-specimen shows mononuclear infiltration of fascia and interstitial myositis with rare eosinophils. A blood eosinophilia (900/ul) occurs only in the initial acute onset of the illness. Plasma level of Kynurenine is significantly high (4000 pmol/ml), collagenneosynthesis is activated (Procollagen type III peptid 0.927 U/ml). No significant clinical improvement was seen with Acathioprine (100 mg/d) and Prednisolon (40-60 mg/d), after treatment with Ciclosporin scleroderma regresses completely, polyneuropathy is persisting.

Biopsy↗