Biomedical subjects
Publications and source records attributed to S Schauder.
Anthralin has been applied in low and high concentrations with and without UV-irradiation in the treatment of psoriasis (Schauder & Mahrle, 1982a,b). We have studied the relationship between the sensitivity to anthralin and UV-irradiation which might possibly help us to give a more individually adapted therapy.
A total of 66 patients with psoriasis was treated with one percent anthralin for one hour (one-hour-treatment) and UV-light. 17 out of 26 out-patients treated with anthralin and UVB showed a good response. In 40 in-patients the one hour regimen was administered in combination with UVA or UVB, in part in right-left side comparison in order to evaluate whether anthralin with UV-light is more effective than anthralin alone. Within six weeks remission was obtained with anthralin alone as well as with combined treatment with anthralin and UVA or UVB. In right-left side comparison UV-light had no significant additional effect in this regimen. The one-hour-treatment was effective but did not seem to be superior to the conventional therapy with anthralin in in-patients. However, the one-hour-treatment is advantageous and convenient for out-patients.
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Fifty-one patients with psoriasis were treated with 1% anthralin for 1 h (1-h treatment) and UV-light. Seven of 11 out-patients treated with anthralin and UV-B showed a good response. In 40 in-patients the 1-h regimen was administered in right-left side comparison to evaluate (1) whether UV-A or UV-B combined with anthralin was more effective than anthralin alone and (2) whether anthralin was photoactivated by UV-A or UV-B. As to the latter, one body side of the patients was exposed to UV radiation before and the other body side after application of anthralin. In in-patients the response to therapy was monitored by a defined score system. We did not find any significant differences in the paired comparisons. We therefore summarized the different treatment regimens and rated 42% with very good or good, 26% with fair, and 32% with poor. The results show that the 1-h treatment with 1% anthralin seems to be advantageous especially for the treatment of out-patients with circumscribed chronic psoriatic lesions. UV-light did not improve considerably the therapeutic effect of anthralin in the regimen of this study.
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26 patients with generalized psoriasis were treated with oral Retinoid (Ro 10-9359; 50-150 mg/day) and radiations (2-5 times per week) with two different light sources emitting UVA and UVB. In 22 patients, remission was seen with only few remaining lesions at the predilection sites within 35 days. There was no obvious difference in the effect of the two light sources. 17 patients remained free from lesions for several months under a low-dose treatment with Ro 10-9359 and 2-8 radiations per month. The side effects of this treatment were negligible. This therapy is especially suited for outdoor patients with generalized psoriasis.
Photoreactions developed in five of 43 patients being treated for 30 months with repeat doses of DTIC because of metastasing malignant melanoma. An increase in light sensitivity in the UVA and UVB range can be demonstrated by light-testing in the affected patients but not in controls. It shows a decrease with the metabolism of DTIC. The increase in light sensitivity serves as an additional argument to avoid light exposure during and after DTIC injections.
Gonococci were isolated from pharyngeal swabs in a woman suffering from genital gonorrhoea. She admitted orogenital contact at her most recent intercourse. A single dose treatment with spectinomycin cured the genital and pharyngeal infections.
Actinic Reticuloid in a Florist A 63 year old florist developed after primary sensibilisation against Chrysanthemum and other flowers and plants the typical clinical and histological features of an actinic reticuloid with considerably augmented sensitivity to UV A and UV B.
The light sensitivity was determined on 14 psoriasis patients using two different light sources before, and after a three week period of systemic administration of 75 to 100 mg daily of the aromatic retinoid (ethyl ester of all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, Ro 10-9359 [1]). The results indicate that with this therapy, the light sensitivity remains unchanged or even decreases; there is thus no contraindication to the simultaneous application of phototherapy and the systemic administration of this retinoic acid derivative.
The antibiotic olaquindox, an ingredient added to porker feed to increase overall performance, caused a photoallergic contact eczema and subsequently a chronic photosensitive dermatitis with increased UV-A- and UV-B-sensitivity in a breeder of small pigs. Through the use of sun creams he developed an additional (photo)allergic contact eczema to the sunscreens contained in the creams.