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Biomedical subjects

S Saxena

Publications and source records attributed to S Saxena.

At least 253 records · Page 14Linked to original sources
PubMed1985

In vitro alpha-interferon treatment of peripheral blood mononuclear cells improves interleukin-2 activity in HBV-related chronic liver disease.

To investigate mitogen-induced helper T cell activity in patients with HBV-related chronic liver disease (CLD), Interleukin-2 (IL-2) activity was assessed by an IL-2 bioassay using phytohaemagglutinin (PHA)-stimulated mononuclear cells (MNC). IL-2 activity was significantly reduced in patients with CLD (P less than 0.01), and was comparable to controls in those with minimal liver damage, indicating that decreased IL-2 activity is not due to the presence of HBV X MNC from 2 of the 3 patients treated with alpha-interferon (alpha-IFN) showed the highest IL-2 activity. In vitro preincubation of MNC with alpha-IFN before stimulation with PHA, led to a significant increase in IL-2 activity in all subjects (P less than 0.01). The improvement in IL-2 activity induced by alpha-IFN may be, in part, responsible for the therapeutic effect of this agent in HBV-related CLD.

Adult↗
PubMed1985

Immunosuppression by human seminal plasma.

Immunosuppressive property of normal human seminal plasma has been demonstrated on various in vitro immune parameters such as, blast transformation of lymphocytes with Phytohemagglutinin (P), Concanavalin A and Lipopolysaccharide, E & EAC rosette formation and mixed lymphocyte culture. The immunosuppression appears to be a T-cell mediated phenomenon. Analysis of semen samples obtained from 86 donors, comprising azoospermic, oligospermic, normospermic and polyspermic individuals, suggests that immunosuppression of the seminal plasma has no correlation with either the sperm density or the protein content of seminal plasma. The possible implication of the immunosuppressive activity in the development of acquired immuno-deficiency syndrome is also discussed.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Experience with the routine use of an abbreviated crossmatch.

Three years' experience with the routine use of an abbreviated crossmatch procedure is reported. If a patient had no known history of and/or no currently demonstrable unexpected antibodies, ABO and Rh type specific blood was crossmatched at the time of need by using an immediate spin saline abbreviated crossmatch. Once blood was issued, both a 37 degrees C incubation and an antiglobulin crossmatch were done using the same tube employed for the abbreviated crossmatch. This served as a check that clinically significant antibodies were not overlooked. None of the 19,818 patients transfused following an abbreviated crossmatch suffered an acute hemolytic transfusion reaction as a result of this strategy; however, two patients may have manifested asymptomatic hemolysis. This approach to compatibility testing might be appealing to hospitals faced with fiscal limitations and new regulations affecting hospital reimbursement.

Adult↗
PubMed1984

Neonatal exchange transfusions complicated by transfusion-induced malaria.

Two neonates who became infected with Plasmodium vivax subsequent to exchange transfusion are described. This complication of neonatal exchange transfusion is unusual in that only two other similar cases have been reported to the Centers for Disease Control. Although malaria is an unusual complication, it should be kept in mind when considering the differential diagnoses of fever following neonatal exchange transfusion. The risk of transfusion-induced malaria may be increasing due to the influx of immigrants from areas endemic for malaria. Careful blood donor selection and blood donor education may minimize this risk.

Diagnosis, Differential↗