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Biomedical subjects

S Saxena

Publications and source records attributed to S Saxena.

At least 235 records · Page 13Linked to original sources
PubMed1987

Platelet counts in three racial groups.

Documented differences exist in red blood cell (RBC) and granulocyte counts between black and white people. However, little comparative information is available on differences in platelet counts in the two racial groups. Therefore, this study was performed to compare platelet counts in healthy white (94), black (92), and Latin-American (63) persons. Black women had significantly higher platelet counts than did white women (P less than 0.025). Latin-American women were between the other two groups. No differences were noted among men. Black women also had a significantly higher prevalence of iron deficiency and microcytosis of RBCs than did white women. After exclusion of women with either microcytosis or iron deficiency, racial differences in platelet counts were no longer evident. The authors conclude that the differences in the platelet counts between black and white women were secondary to common RBC differences (such as iron deficiency and other causes of microcytic anemia) and were not intrinsic to the platelets. These and other factors that can affect platelet counts should be excluded before determining the reference ranges for proper interpretation of the platelet counts.

Black or African American↗
PubMed1987

Racial differences in vitamin B12 levels in the United States.

Studies from Africa have demonstrated that black people have higher vitamin B12 (cobalamin) levels than do white people. The authors compared healthy white people, black people, and Latin-Americans in the United States. Their study is also the largest in which the effect of race and sex on the cobalamin levels has been examined. Analysis of 233 healthy subjects showed that black people had significantly higher (P less than 0.0001) vitamin B12 levels than did white people. Latin-Americans had levels intermediate between those of white and black people, although their levels were significantly different only in comparison with white people (P = 0.0029). Based on the study of 305 healthy subjects, no sex difference in vitamin B12 levels was noted. Conflicting claims have been made on sex difference in the past. The authors conclude that there is a racial but not a sex difference in vitamin B12 levels in the United States. Like African black people, black people and Latin-Americans in this country have significantly higher vitamin B12 levels than do white people. This finding supports the thesis that genetic factors contribute to the racial differences in vitamin B12 levels.

Black or African American↗
PubMed1987

Studies on circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) in tropical pulmonary eosinophilia.

Circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) was studied in ten healthy controls and 25 patients with tropical pulmonary eosinophilia (TPE). Subjects were synchronized for 1 week with diurnal activity from 0600 to 2200 hr and nocturnal rest; meals were taken at 0830, 1300, and 2030 hr. No medications were administered. TPE patients were divided into three subgroups of fourteen, seven, and four each according to the hour of the worsening of their symptoms. Blood samples were collected at 8-hr intervals at fixed clock hours for 24 hr, starting at 0800 in all four groups. We noted a marked rhythm in plasma 17-OHCS in controls, with significant amplitude and an acrophase at 1033 hr. Similarly, all TPE patients exhibited a definite rhythm in plasma 17-OHCS with significant amplitude irrespective of the time of worsening of symptoms, suggesting thereby no relationship between worsening of symptoms and the rhythm. Thus the circadian nature and normal concentration of plasma 17-OHCS were observed to be similar in healthy controls and TPE patients.

17-Hydroxycorticosteroids↗
PubMed1987

The impact of alanine aminotransferase testing on Hispanic blood donations.

The American Association of Blood Banks, Arlington, Va, has required that all blood donors must be tested for serum alanine aminotransferase (ALT), and that donations from donors with ALT levels above a certain cutoff value must be discarded. To assess the impact of this requirement on different ethnic/racial groups, the ALT levels of 1781 blood donors were compared. Hispanic blood donors had significantly higher ALT levels than did black and non-Hispanic white blood donors. No significant difference in ALT was seen between black and non-Hispanic white blood donors. We conclude that there are statistically significant differences in the ALT levels between Hispanic and non-Hispanic blood donors, and that a disproportionate number of Hispanic blood donations (11% to 13%) will be discarded as a result of testing blood donors for ALT.

Alanine Transaminase↗
PubMed1986

Prediction of postdexamethasone cortisol levels by serum sodium levels in patients with major depression.

The authors analyzed the dexamethasone suppression test (DST) results of 54 patients with major depressive disorder in relation to their pre-DST levels of cholesterol, sodium, potassium, and blood glucose, which are thought to have adrenocorticotrophic links. Discriminant analysis revealed that sodium alone was a significant predictor of nonsuppression. Validation of the predictive power of sodium could minimize the need for DST administration.

Adult↗
PubMed1986

Interleukin 2 activity in chronic liver disease and the effect of in vitro alpha-interferon.

To investigate mitogen induced helper interleukin 2 (IL-2) production in patients with chronic liver disease (CLD), IL-2 activity was assessed by an IL-2 bioassay using phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMNC). IL-2 activity was significantly reduced in patients with autoimmune chronic active hepatitis, primary biliary cirrhosis and alcoholic hepatitis with or without cirrhosis (P less than 0.01), and was comparable to controls in those with alcoholic cirrhosis alone. In vitro preincubation of PBMNC with lymphoblastoid alpha-interferon (alpha-IFN) before stimulation with PHA, led to a significant increase in IL-2 activity in all subjects (P less than 0.01), except those with alcoholic hepatitis, but in none of the groups did the levels of IL-2 activity reach those seen in normal subjects. The decrease in IL-2 activity in patients with CLD may be due to low IL-2 production or presence of an IL-2 antagonist(s). Such an abnormality may occur, not only as a result of liver damage, but may also be important in determining immunological disturbances involved in the pathogenesis of the liver disease.

Adult↗
PubMed1985

The structure of certain newly synthesized non-bridged and bridged cyclopentadienyl titanium complexes and their insecticidal activity.

Three bridged and non-bridged cyclopentadienyl titanium complexes, synthesized in our laboratory, were tested for their insecticidal activity against Trogoderma granarium (Everts), the Khapra beetle, and show moderate toxicity towards this product pest. The non-bridged derivatives have been observed to be slightly more active than the bridged ones.

Animals↗