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Biomedical subjects

S Sakuma

Publications and source records attributed to S Sakuma.

At least 397 records · Page 22Linked to original sources
PubMed1975

Demonstration of immunoglobulin G receptors induced by human cytomegalovirus.

Human cytomegalovirus induced a new immunoglobulin G receptor in human fibroblasts. The immunoglobulin G receptor was well localized in the perinuclear region at 48 h postinfection, and antiviral agents blocked its synthesis. The immunoglobulin G receptor bound immunoglobulin G of man and several other species. It may be a source of error in the performance of indirect fluorescence tests for human cytomegalovirus antibody.

Antibodies, Viral↗
PubMed1975

Effects of vasopressin in experimental nephroangiography.

Nephroangiography was performed in 13 rabbits using eight-fold magnification with a 0.05 mm focus. After arginine vasopressin in doses of 0.01 to 1.0 IU the glomeruli were well demonstrated as well as the subcortial arteries and veins and the concentration of contrast medium in arteries and veins increased. At increasing doses of vasopressin the glomeruli were shut off to an increasing degree, beginning at the outer part of the cortex. At 1.0 IU only the juxtamedullary glomeruli functioned.

Animals↗
PubMed1975

Articular lesions in experimental Erysipelothrix insidiosa infection in rats.

Articular lesions were studied in the extremities and vertebral column in murine erysipelas infection. Pathologic alterations found in those different joint systems were essentially the same in character. In the early stage of infection, phlegmon-like inflammation was observed in the periarticular loose connective tissue. Abundant fine Gram-positive bacilli were free in inflamed edematous tissue. Then, active serofibrinous exudation and emigration of leukocytes occurred in the synovial membrane, articular cartilage, annulus fibrosus, and nucleus pulposus with the development of the disease. These exudative changes disappeared gradually. Instead of them, proliferation of synovial cells accompanied by dense infiltration with lymphocytes and plasma cells became conspicuous. At the same time, chondro- and osteoclastic activity occurred in the joints of the extremities or regions adjacent to the intervertebral disk. Capsular and subchondral pannus often resulted from an excessive proliferation of granulation tissue. In the late stage, they synovial membrane and granulation tissue underwent fibrosis, adhesion and ossification. Finally, these changes resulted in fibrous or bony ankylosis and deformation. Gram-positive bacilli were hardly detected in histological preparations derived from animals in the chronic stage when proliferative change was predominant in the articular lesions.

Animals↗