Biomedical subjects

S S Kroll

Publications and source records attributed to S S Kroll.

At least 55 records · Page 3Linked to original sources

PubMed1998

Repair of partial mastectomy defects.

Deformities caused by partial mastectomy can often be helped by plastic surgical techniques. Immediate repair of partial mastectomy defects is especially useful when skin, as well as breast tissue, has been resected. Distant tissue can be used, but most partial mastectomy defects are best repaired with local flaps. Shifting the defect into the axilla, where it is less noticeable, is often helpful. Alternatively, the breast can be reshaped using techniques similar to those used in reduction mammaplasty. In that situation, reduction of the opposite breast often is indicated for symmetry.

Female↗

PubMed1998

Choice of technique for reconstruction.

This article discusses the complex set of issues that go into choosing a technique for breast reconstruction. These factors include not only the technical aspects of breast restoration, but oncologic care, psychologic factors, and patient preference. The various flap options and indications for them are described.

Choice Behavior↗

PubMed1997

Ischemic time and free flap success.

Ischemic time (the time between the interruption and reestablishment of blood supply) was reviewed for 700 free flaps used for breast or head and neck reconstruction. Flaps that failed had a mean ischemic time of 111.64 minutes, while flaps that survived had a mean ischemic time of 91.25 minutes. The difference was not statistically significant (p = 0.189). The patients were then divided into two groups: those with flap ischemic times of 100 minutes or longer and those with flap ischemic times less than 100 minutes. We found that flap survival was similar in the two groups. Flap survival was also similar when 75 minutes and 120 minutes were used to segregate the longer and shorter ischemic time groups. When 180 minutes was used to segregate the groups, there was a slight trend toward more flap loss in the group with longer ischemic time, but the difference was not significant. We conclude that ischemic time is irrelevant to flap survival, provided that ischemia is not prolonged past 3 hours or to the point where the no-reflow phenomenon occurs.

Anastomosis, Surgical↗

PubMed1997

Adjuvant therapy: the effects on microvascular lower extremity reconstruction.

Adjuvant therapy and microsurgery have allowed advances in surgical extirpation of lower extremity neoplasms. This retrospective study was designed to evaluate the microvascular transfer for lower extremity reconstruction in patients receiving pre- or post-operative irradiation and chemotherapy alone and in combination. Over a 5-year period, 24 free tissue transfers were performed in 22 patients undergoing surgical resection with adjuvant therapy for lower extremity neoplasms. There were 13 male and 9 female patients with an average age of 51 years. The latissimus dorsi muscle was most commonly transferred (N = 15). Eighteen tumors received pre- and three received postoperative radiotherapy. Two tumors received a combination of radiotherapy and brachytherapy. Pre- and/or postoperative chemotherapy was used in 14 patients. Twelve of these patients had both chemo- and radiation therapy. A total of six complications occurred, with no flap loss. Complications were evenly distributed among adjuvant regimens. All patients who underwent attempted limb salvage were able to ambulate postoperatively, except for 1 patients who had local recurrence. In conclusion, adjuvant therapy did not increase the complication rate for free tissue transfer in the lower extremity. Adjuvant therapy did not require alterations in the free tissue transfer and, similarly, free tissue transfer did not alter adjuvant therapy. We believe that free tissue transfer in complicated wounds allows for better wound healing with adjuvant therapy rather than local or primary wound closure alone.

Adult↗

PubMed1997

A comparison of resource costs for head and neck reconstruction with free and pectoralis major flaps.

A series of 178 immediate reconstructions with regional or distant tissue for repair of oropharyngeal defects caused by treatment of head and neck cancer was reviewed to determine whether reconstruction with free flaps was more or less expensive than reconstruction with regional myocutaneous flaps. In this series, three types of flaps were used: the radial forearm free flap (n = 89), the rectus abdominis free flap (n = 56), and the pectoralis major myocutaneous flap (n = 33). Resource costs were determined by adding all costs to the institution of providing each service studied using salaried employees (including physicians). The two free-flap groups were combined to compare free flaps with the pectoralis major myocutaneous flap, a regional myocutaneous flap. Failure rates in the two groups were similar (3.0 percent for pectoralis major myocutaneous flap, 3.4 percent for free flaps). The mean costs of surgery were slightly higher for the free flaps, but the subsequent hospital stay costs were lower. Therefore, the total mean resource cost for the free-flap group ($28,460) was lower than the cost for the myocutaneous flap group ($40,992). The pectoralis major myocutaneous flap may have been selected for more patients with advanced disease and systemic medical problems, contributing to longer hospitalization and added cost. Nevertheless, this study suggests that free flaps are not more expensive than other methods and may provide cost savings for selected patients.

Age Factors↗

PubMed1997

Total sacrectomy and Galveston L-rod reconstruction for malignant neoplasms. Technical note.

Although radical resection is the best treatment for malignant sacral tumors, total sacrectomy for such tumors has been performed in only a few instances. Total sacral resection requires reconstruction of the pelvic ring plus establishment of a bilateral union between the lumbar spine and iliac bone. This technique is illustrated in two patients harboring large, painful, sacral giant-cell tumors that were unresponsive to prior treatment. These patients were treated with complete en bloc resection of the sacrum and complex iliolumbar reconstruction/stabilization and fusion. Surgery was performed in two stages, the first consisting of a midline celiotomy, dissection of visceral/neural structures, and ligation of internal iliac vessels, followed by an anterior L5-S1 discectomy. The second stage consisted of mobilization of an inferiorly based myocutaneous rectus abdominis pedicle flap for wound closure, followed by an L-5 laminectomy, bilateral L-5 foraminotomy, ligation of the thecal sac, division of sacral nerve roots, and transection of the ilia lateral to the tumor and sacroiliac joints. Placement of the instrumentation required segmental fixation of the lumbar spine from L-3 down by means of pedicle screws and the establishment of a bilateral liaison between the lumbar spine and the ilia by using the Galveston L-rod technique. The pelvic ring was then reestablished by means of a threaded rod connecting left and right ilia. Both autologous (posterior iliac crest) and allograft bone were used for fusion, and a tibial allograft strut was placed between the remaining ilia. The patients were immobilized for 8 weeks postoperatively and underwent progressive rehabilitation. At the 1-year follow-up review, one patient could walk unassisted, and the other ambulated independently using a cane. Both patients controlled bowel function satisfactorily with laxatives and diet and could maintain continence but required self-catheterization for bladder emptying. The authors conclude that in selected patients, total sacrectomy represents an acceptable surgical procedure that can offer not only effective local pain control, but also a potential cure, while preserving satisfactory ambulatory capacity and neurological function.

Adult↗

PubMed1997

Comparison of nipple projection with the modified double-opposing tab and star flaps.

This study compared nipple projection after nipple reconstruction (following breast mound reconstruction) with either the modified double-opposing tab flap or the star flap. Areolar reconstruction and pigmentation of the nipple were achieved with tattooing. Nipple projection for 153 nipples was measured at least 6 months after the reconstruction, when projection was believed to have become stable. Mean follow-up was 2.27 years. In the 106 nipples reconstructed with modified double-opposing tab flaps, the mean projection was 2.4292 mm, while in the 47 nipples reconstructed with star flaps, the mean projection was 1.9681 mm (p = 0.021). We conclude that although both methods are effective, the modified double-opposing tab flap has slightly more projection after approximately 2 years. It is not known, however, whether this is because of reduced flap atrophy or longer initial projection by the modified double-opposing tab flap; further studies are ongoing.

Female↗

PubMed1997

Immediate breast reconstruction. A review.

In summary, immediate breast reconstruction has many advantages to the patients and to the surgeons who perform breast reconstruction. For the patients, it is less expensive, psychologically easier, and more convenient. For the surgeons, it facilitates the reconstruction and improves the aesthetic results. Oncologically, there is no reason not to perform immediate breast reconstruction unless the patient does not want it or the prognosis is so poor that any breast reconstruction is unwarranted. We generally offer immediate breast reconstruction to all patients with in situ, T1, or T2 breast cancers who are appropriate surgical candidates. We also offer it to selected patients with T3 breast cancers if the patients are good surgical candidates and are anxious to undergo immediate reconstruction. Skin-sparing mastectomy combined with immediate breast reconstruction has improved the quality of our results and the quality of our patients' lives. By helping our patients in this manner, it has increased the amount of pride we can take in our work and therefore the quality of our own lives as well.

Adult↗

PubMed1996

Comparison of resource costs between implant-based and TRAM flap breast reconstruction.

Resource costs, as measured by hours of time in the operating room, days of stay in the hospital, and other costs of care, were evaluated for 240 patients who underwent mastectomy with immediate breast reconstruction using either TRAM flaps or breast implants at The University of Texas M. D. Anderson Cancer Center. To make costs comparable, only patients who completed reconstruction of the nipple were included. As expected, the initial resource costs of implant-based reconstruction were much lower than those of TRAM flap reconstruction. After correcting for patients whose reconstructions were unsuccessful and including the costs of surgery subsequent to the initial reconstruction, however, the cost advantage of implant-based reconstruction disappeared. If current trends continue, it is likely that with increased follow-up, the long-term resource costs of implant-based reconstructions will continue to increase, while those of autogenous tissue reconstructions will not. Autogenous breast reconstruction with the TRAM flap therefore appears to be more cost-effective, in terms of time as well as dollars, in the long run than reconstruction based on prosthetic implants.

Breast Implants↗

PubMed1996

Silicon tissue assays: a comparison of nonaugmented cadaveric and augmented patient levels.

Tissue silicon assays were performed on 10 nonaugmented cadavers and 25 augmented women to confirm our previous cadaveric data and to establish silicon levels at local and distant sites in augmented women undergoing explant and further reconstruction. All assays were performed by inductively coupled plasma atomic emissions spectroscopy (ICP-AES). Cadaveric tissues were sampled from six sites: liver, spleen, breast, nipple, axilla (soft tissue and nodes), and subcutaneous tissue (abdominal). Augmented women undergoing explant surgery had a portion of their implant capsule, breast tissue, and for those undergoing autogenous reconstruction, a portion of the autogenous donor site or distant tissue sampled. Twenty-four women had silicone implants; one had saline. Results revealed baseline silicon levels in all 10 non-augmented cadavers. These results were equivalent to our previous data, confirming the validity of these baseline data. Silicon tissue levels in the 25 augmented women revealed elevated levels within the implant capsule and surrounding breast tissue. However, silicon levels obtained from distant sites in augmented women were equivalent to the baseline nonaugmented cadaveric levels. There was no correlation between intact or ruptured implants and symptoms of collagen-vascular disease. In conclusion, study validates our original data of baseline silicon levels in nonaugmented cadavers. Contrary to what some may perceive as silicone floating throughout the body, we have found elevated levels around the implant only, and levels at distant tissue sites were equivalent to the baseline cadaveric data.

Abdomen↗

PubMed1996

Comparison of resource costs of free and conventional TRAM flap breast reconstruction.

Resource costs, which are the costs to the hospital of providing a service, were measured for 154 patients who underwent mastectomy and immediate breast reconstruction with TRAM flaps. Unilateral and bilateral reconstructions were evaluated separately. The resource costs required to perform mastectomy and reconstruction with free TRAM flaps were then compared with those required when conventional TRAM flaps were used. The mean total resource cost in the free TRAM group was slightly higher than in the conventional TRAM group, but the difference was small (4.1 percent) and not statistically significant (p = 0.290). The mean resource cost of performing bilateral mastectomy and reconstruction was higher than that of unilateral mastectomy and reconstruction, but the difference was only 5.0 percent (p = 0.046). This study shows that the cost to an institution of providing breast reconstruction with free TRAM flaps is not significantly higher than that of performing reconstruction with conventional TRAM flaps. Also, our findings show that the resource costs of performing bilateral mastectomy and reconstruction are not much higher than those of treating only one breast.

Female↗

PubMed1996

Choice of flap and incidence of free flap success.

A review of 854 consecutive free flaps was performed to determine whether the choice of flap used for the reconstruction influenced the probability of a successful outcome. Flaps were grouped into nine categories: rectus abdominis, free transverse rectus abdominis myocutaneous, radial forearm, jejunum, latissimus dorsi, fibula, scapula, iliac crest, and other. There were significant differences among the success rates of different flaps (p < 0.0001). Rectus abdominis-based flaps used for breast or head and neck reconstruction had lower failure rates (0.9 percent) than did non-rectus abdominis flaps (6.6 percent; p < 0.0001). Flaps requiring vein grafts had a higher rate of flap loss (18.4 percent) than did flaps that did not require vein grafts (2.9 percent; p < 0.0001). There was a strong trend favoring survival of flaps without a bone component (compared with osteocutaneous flaps), and a weaker trend favoring survival of flaps in nonobese patients (compared with flaps in obese patients). Smoking, age, and previous irradiation had no significant effect on flap failure rates. Surgeons should consider the flap success rate as one (but not necessarily the most important) factor in choosing the best reconstruction for any individual patient.

Breast Neoplasms↗

PubMed1996

The vermilion-sharing graft for repairing a vermilionectomy defect.

Lower lip vermilionectomy defects can be repaired with a full-thickness graft of vermilion from the upper lip. The graft width should be approximately one-half that of the lower lip defect, sharing the vermilion between the two lips. The graft should be oriented so that the red, anterior part of the vermilion is placed anteriorly, where it will be most visible. If graft "take" is successful, the result can be aesthetically and functionally excellent, while the donor-site morbidity is minimal.

Aged↗

PubMed1996

Timing of pedicle thrombosis and flap loss after free-tissue transfer.

A series of 990 consecutive free flaps was reviewed to determine how often pedicle thrombosis occurred, when it occurred, and if the timing of thrombosis detection had any relationship to the probability of flap salvage. The overall thrombosis rate was 5.1 percent, and the flap loss rate was 3.2 percent. The majority (80 percent) of thrombi occurred within the first 2 postoperative days. Only 5 thrombi (10 percent) were known to have occurred after the third postoperative day. No flaps that developed thrombosis after the third postoperative day were salvaged successfully. Had flap monitoring been discontinued after the first 3 postoperative days, our results in this series would have been unchanged. Thrombosis of the vein (54 percent) was more common than arterial thrombosis (20 percent) or thrombosis of both artery and vein (12 percent). Almost all purely arterial thrombi (90 percent) occurred before the end of the first postoperative day, whereas 41 percent of all venous thrombi occurred later. We conclude that arterial monitoring is most critical immediately after surgery. Beginning on the second postoperative day, venous monitoring becomes progressively more important to flap success. The cost-effectiveness of postoperative monitoring of free flaps is greatest during the first 2 days, after which it decreases significantly.

Graft Rejection↗

PubMed1996

Skin-sparing mastectomy with immediate breast reconstruction.

Skin-sparing mastectomy with immediate reconstruction has become popular with patients because compared to delayed reconstruction it improves the cosmetic result and reduces cost and anesthetic risk. In one stage, it completes most of the surgical treatment the patient will ever require for treatment of her breast cancer. It eliminates the need to live with the deformity caused by mastectomy and thereby contributes to a more positive body image. It does not increase the risk of local or regional recurrence and when properly performed, especially with autogenous tissue, does not interfere with adjuvant therapy. We believe strongly that skin-sparing mastectomy with immediate reconstruction is a significant advance in the treatment of breast cancer: it provides patients an improved cosmetic outcome with less emotional trauma and morbidity. We encourage qualified surgeons to use this method of breast reconstruction whenever possible.

Breast Implants↗

PubMed1995

Microvascular craniofacial reconstruction in cancer patients.

BACKGROUND: Resections of large malignancies involving the middle and upper thirds of the face and cranium result in complex defects, posing a difficult challenge for the reconstructive surgeon. Free tissue transfer may be the best means of reconstruction. METHODS: We reviewed 54 consecutive microvascular craniofacial reconstructions after tumor ablation performed at the University of Texas M.D. Anderson Cancer Center from May 1988 to September 1992. Information regarding patient characteristics, tumor stage and histology, history of prior therapy, the defect after tumor ablation, and the details of the reconstruction were entered in a microcomputer database at the time of the initial surgery. Free flap outcome, the number and type of complications, control of malignant disease, and the use of adjuvant therapy were recorded prospectively. RESULTS: Patients had defects of the scalp and cranium (15 of 50) or of the maxilla/orbit/cranial base (35 of 50) after resections for a variety of tumors. Immediate reconstruction was completed in 40 patients and delayed in 10. Prior therapy included surgery (39 of 50) and/or radiotherapy (35 of 50). The free flap success rate was 96% (52 of 54). In patients with successful flaps, significant wound complications occurred in 13.5% of patients (seven of 52) and donor site problems in 11.1% (six of 54) for an overall complication rate of 24.1% (13 of 54). There were no operative deaths or neurologic complications. The timing of surgery or a history of prior surgical therapy or radiotherapy did not significantly influence the complication rates. CONCLUSION: Free tissue transfers provide optimal restoration of large craniofacial defects resulting from cancer resection.

Combined Modality Therapy↗

PubMed1995

Perineal wound closure with the rectus abdominis musculocutaneous flap after tumor ablation.

BACKGROUND: We describe the transpelvic rectus abdominis musculocutaneous flap for closing large, often irradiated, perineal defects in patients with cancer. METHODS: We studied 9 men and 17 women who underwent wide excision of advanced T3 and T4 tumors and who had preoperative chemotherapy, radiotherapy, or both. After tumor ablation, we used a transpelvic rectus abdominis musculocutaneous flap to fill pelvic dead space and primarily close the perineal wounds. Twelve simultaneous vaginal reconstructions were performed. RESULTS: Wounds healed promptly in 14 patients. Healing was delayed in the remaining 12 patients due to poor flap adherence to irradiated tissue beds (9), complete flap loss (2), or partial flap loss (1). Delayed healing was associated with the combination of obesity and prior irradiation. Other perioperative complications included localized abdominal wound infection (2), enterocutaneous fistula (1), and abdominal herniation (1). Local disease was controlled in 20 of 26 patients. Mean follow-up was 22 months. CONCLUSION: Transpelvic rotation of the rectus abdominis musculocutaneous flap facilitates healing large, difficult, perineal wounds, resulting from cancer ablation.

Adult↗

PubMed1995

The internal oblique repair of abdominal bulges secondary to TRAM flap breast reconstruction.

The internal oblique repair, a new method for repair of abdominal bulging following TRAM flap breast reconstruction, involves identification and repair of the internal oblique fascia. To assess the usefulness of this repair and to compare it with simple plication of the deep abdominal fascia, we retrospectively reviewed all abdominal bulge repairs performed by the first author over the past 7 1/2 years. Of 30 abdominal bulge repairs, the internal oblique repair was used in 14 patients and plication in 16 others. The bulge recurrence rate was lower after the internal oblique repair (21 percent) than after the plication repair (69 percent; p = 0.028). When synthetic mesh reinforcement was added to the internal oblique repair, the bulge recurrence rate dropped to 13 percent. We conclude that the internal oblique repair is the preferred technique for the correction of abdominal bulges secondary to TRAM flap breast reconstruction.

Abdominal Muscles↗