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Biomedical subjects

S Ross

Publications and source records attributed to S Ross.

At least 253 records · Page 14Linked to original sources
PubMed1977

Clindamycin in the treatment of osteomyelitis in children: a report of 29 cases.

Clindamycin phosphate was used in the treatment of 29 children with osteomyelitis of whom 25 had an acute and four a chronic type of infection. The usual dose was 50 mg/kg/day intravenously for approximately three weeks followed by oral clindamycin palmitate at home in a dose of 30 mg/kg/day for an additional six weeks. Staphylococcus aureus was isolated in 22 of 29 cases: 96% of strains were penicillin resistant. The clinical and bacteriologic results in the present series were good to excellent. There was prompt clinical and bacteriologic response shortly after initiation of clindamycin therapy. Good bone penetration of the drug was observed. Long-term evaluation revealed satisfactory clinical and roentgenographic progress in all patients. No diarrhea or manifestations of enterocolitis appeared in any patient in spite of high doses of the drug for intervals up to nine weeks.

Acute Disease↗
PubMed1977

Cerebrospinal fluid lactic acid levels in meningitis.

Measurement of cerebrospinal fluid lactic acid by gas liquid chromatography and by an enzymatic Monotest lactate test was evaluated for the early detection of bacterial meningitis in 396 patients. Spinal fluid specimens from 62/62 patients with a bacterial or mycoplasma etiology yielded lactate levels greater than the upper limits of normal, whereas specimens from 334 patients with no bacterial involvement gave values within the normal range. The duration of elevated CSF lactate values coincided with the clinical response to therapy. When considered along with the history and physical examination of the patient, determination of lactic acid proved to be a rapid and reliable diagnostic test for the early detection of untreated as well as partially treated pyogenic meningitis.

Adolescent↗
PubMed1977

The cephalosporin antibiotics in pediatric practice.

The efficacy of the cephalosporins against gram-positive cocci and some of the gram-negative bacilli together with their relative safety make this family of antibiotics potentially useful in treating pediatric infections, particularly in instances of penicillin hypersensitivity. Newer cephalosporins have broadened the antimicrobial spectral range and may offset some of the previous drawbacks to their use in children. Of potential interest to the pediatrician is the highly active inhibitory effect against Hemophilus influenzae by cefamandole, one of the newer cephalosporin congeners.

Administration, Oral↗
PubMed1977

Signal enhancement for detection of specialized atrioventricular conduction system electrograms during open-heart surgery.

A method for signal enhancement of electrograms of the specialized atrioventricular conduction system is presented. This method allows a single electrogram to replace the tracings of bipolar electrograms previously required to ensure recognition of the specialezed conduction system and yet maintains the safety afforded by use of three pairs of recording electrodes. In addition, this new signal is enhanced in magnitude and is always unidirectional (positive). These features are desirable for automated signal recognition. This method therefore provides an important step toward future automation and signal recognition of specialized conduction system electrograms during open-heart surgery.

Animals↗
PubMed1976

Mycoplasma T strains and perinatal death.

In 23 out of 290 perinatal deaths in Addis Ababa, mycoplasma T strains were the only organisms responsible for congenital pneumonia and death. All but 2 of the infants were stillborn, 16 dying during the last six weeks of gestation. Infections apparently occurred through intact fetal membranes.

Animals↗
PubMed1976

Intraoperative recording of the His bundle electrogram in man. An assessment of its precision.

To estimate the effect of distance between the electrode and the signal source on the amplitude of the His bundle electrogram (HBE) recorded during open heart surgery, a specially designed probe, containing six pairs of closely spaced (1 mm) electrodes was placed on the endocardial surface of the right atrium such that each electrode pair was parallel to the course of the His bundle. The amplitude of the HBE recorded through electrodes closest to the His bundle ranged from 0.76 to 2.44 mV, at 1mm from 0.38 to 1.13 mV, at 2mm from 0.27 to 0.86 mV, and at 3 mm from 0.2 to 0.44 mV. Maximal amplitude of HBE decreased by 57% at 1mm, 73% at 2 mm, and 82% at 3mm. The percent decrease was initially rapid, then declined more slowly at distances greater than 1 mm, resembling in form data obtained previously in animal studies by different techniques. Since the maximum HBE was greater than 1.0 mV in nine of 11 patients, and equal to or greater than 1.0 mV in only two of 11 patients at 1 mm, and less than 1.0 mV in all patients 2.0 mm from the maximal HBE, the anatomic location of the His bundle can be estimated from HBE amplitude. Intracardiac electrograms, recorded through closely spaced bipolar electrodes during open heart surgery, afford clinically useful precision in locating the specialized conduction tissue of the heart.

Adolescent↗
PubMed1975

Limulus lysate test for gram-negative bacterial meningitis. Bedside application.

The limulus lysate on cerebrospinal fluid was evaluated in 335 infants and children as a method for the rapid diagnosis of Gram-negative bacterial meningitis. Positive limulus tests were obtained within one hour in 33 of 34 cases of Hemophilus influenzae meningitis; four additional patients with Gram-negative meningitis also showed positive limulus lysate tests. Conversely, 13 patients with Gram-positive bacterial meningitis all yielded negative limulus assays. All 48 cases of aseptic meningitis and 236 children with no meningitis showed negative limulus assays. Antibiotic therapy prior to hospitalization did not vitiate the validity of the test. A bedside adaptation of the limulus test, performed by house officers and medical students, showed approximately 98% agreement with the laboratory assay.

Arachnida↗
PubMed1975

S-adenosylhomocysteine inhibition of three purified tRNA methyltransferases from rat liver.

Three tRNA methyltransferases from rat liver have been fractionated and purified greater than 100-fold. These enzymes have been examined for their sensitivity to inhibition by S-adenosylhomocysteine (SAH). The methyltransferase which forms m2-guanine in the region between the dihydrouridine loop and the acceptor stem of tRNA (m2-guanine methyltransferase I) is least sensitive to SAH inhibition, with a Ki of 8 muM. The enzyme responsible for forming m2-guanine between the dihydrouridine and anticodon loops (m2-guanine methyltransferase II) has a Ki of 0.3 muM, while m1-adenine methyltransferase shows intermediate sensitivity to SAH (Ki = 2.4 muM). All three methyltransferases have similar Km's for the S-adenosylmethionine substrate (1.5-2.0 muM). These results are consistent with the hypothesis that activity of individual tRNA methyltransferases may be controlled by enzyme systems which alter cellular SAH levels.

Adenine↗
PubMed1974

Reoviruslike agent in stools: association with infantile diarrhea and development of serologic tests.

Reoviruslike particles were visualized by electron microscopy in stool filtrates prepared from stools of infants and young children with severe acute gastroenteritis. Patients who had such particles in their stools and whose paired acute and convalescent serums were tested developed an antibody response to the reoviruslike agent, which was measured by immune electron microscopy and by complement fixation. The reoviruslike agent was antigenically related to the epizootic diarrhea of infant mice virus and the Nebraska calf diarrhea virus.

Animals↗
PubMed1974

Cell culture studies on the antiviral activity of ether derivatives of 5-hydroxymethyldeoxyuridine.

The antiviral activity of several ether derivatives of 5-hydroxymethyldeoxyuridine against the herpesvirus of infectious bovine rhinotracheitis was determined in monolayer cultures of secondary bovine fetal kidney cells. 5-Methoxy-methyldeoxyuridine (OCH(3)UdR) was found to be markedly inhibitory against this virus. Pretreatment of the cells with OCH(3)UdR, simultaneous addition of OCH(3)UdR with virus to the cells, and postinfection treatment with OCH(3)UdR were found to be effective in inhibiting virus-induced cytopathogenic effect. Against this virus, OCH(3)UdR was found to be as potent as 5-iododeoxyuridine and cytosine arabinoside. The alpha-anomer of OCH(3)UdR did not show antiviral activity. Preliminarly toxicity studies indicate that OCH(3)UdR has a very low acute toxicity.

Animals↗