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Biomedical subjects

S Rogers

Publications and source records attributed to S Rogers.

At least 361 records · Page 20Linked to original sources
PubMed1971

Change in the structure of Shope papilloma virus-induced arginase associated with mutation of the virus.

The change in the state of the virus-induced enzyme associated with a mutation in the virus provides additional evidence that the enzyme is synthesized from virus rather than rabbit genetic information. This change in structure results in differences in stability of polymerization, degree of optical rotary dispersion (ORD) specific rotation, change in elution characteristics from carboxymethyl cellulose, and a reduction in specific activity of the arginase. Liver arginase differs markedly in ORD characteristics from the virus-induced enzyme. In contrast to the virus-induced enzyme, it showed no negative Cotton effect at 233 nm until it was activated with manganese. Manganese had no influence on the ORD spectrum of virus-induced arginase. In addition, liver arginase is denatured by 4 M urea, while the virus-induced enzyme requires 10 M urea for denaturation.

Amino Acids↗
PubMed1971

Liver galactose-1-phosphate uridyl transferase: activity in normal and galactosemic subjects.

The kinetic characteristics of galactose-l-phosphate uridyl transferase have been determined in homogenates of human liver biopsies obtained from control subjects and in 50-fold purified enzyme preparations from liver obtained at autopsy. A standardized assay procedure employing linear kinetics was used to assess the enzyme activity in homogenates of liver biopsy specimens from five control subjects and four patients with congential galactosemia with demonstrated absence of the enzyme activity in red blood cells. Activity of control specimens ranged from 11.8 to 17.2 mmumoles of UDPgalactose formed per min mg of protein. Liver of two galactosemic patients, both Caucasian, possessed no detectable enzyme activity (less than 1-2% of normal). The tissue of two others, both Negro, who are known to be capable of metabolizing intravenously administered galactose, contained easily detectable enzyme at approximately 10% of the controls. No alternate enzymatic activity for formation of UDPgalactose was found in the liver of Negroes with galactosemia that was as active as the residual galactose-l-phosphate uridyl transferase. The data suggest that the residual liver enzyme activity accounts for the ability of Negroes with galactosemia to metabolize limited but significantly large quantities of galactose.

Adult↗
PubMedDate not supplied

Reducing falls in a rehabilitation setting: a safer environment through team effort.

A 2-year falls prevention project has included a concurrent analysis of all falls and a program to prevent falls in a 160-bed rehabilitation hospital. The program has been designed on the basis of the data collected. A consistent follow-up program involves patients and staff in the continuous monitoring of patient safety.

Accidental Falls↗
PubMedDate not supplied

Neutrophil taurine in psoriasis.

Neutrophil taurine was measured in 30 subjects presenting with chronic stable plaque-type psoriasis. The taurine concentration expressed per 5 x 10(6) cells was significantly lower (p < 0.002) in these subjects compared to neutrophil taurine measured in 20 control subjects. In view of increasing evidence proposing possible roles for taurine in maintaining normal neutrophil function coupled with previously observed anti-inflammatory effects of taurine in vitro, an assessment of possible roles of taurine in the aetiology of psoriasis is discussed.

Adult↗
PubMedDate not supplied

Cutaneous lupus erythematosus--a study of clinical and laboratory prognostic factors in 65 patients.

An eleven year review of patients presenting with cutaneous lupus erythematosus (LE) was made in order to determine the frequency of change from discoid LE (DLE) to systemic LE (SLE) and to identify clinical and laboratory prognostic factors. Three of fifty-six (5.4%) patients with DLE progressed to SLE after 1, 13 and 34 years respectively. They had a progressive rash and persistent abnormalities in their full blood count, erythrocyte sedimentation rate, antinuclear antibody and serum immunoglobulins prior to the development of SLE. We recommend that regular longterm monitoring of these indices should be carried out in patients presenting with DLE.

Adolescent↗