Search PubMed⌕ Search

Biomedical subjects

S Ringoir

Publications and source records attributed to S Ringoir.

At least 145 records · Page 8Linked to original sources
PubMed1979

Influence of human urine on phagocytosis.

Human urine may inhibit or activate the phagocytosis by normal human blood of latex, zymosan and inuline. No specific difference was found between the urine of normals and patients with moderate, severe or end stage renal failure. The inhibiting effect was not due to urea or creatinine; the assumption is made that a middle molecular fraction D, which can be isolated by Sephadex G 15 columnchromatography from uraemic ultrafiltrate, is responsible for the observed inhibition. Urines of patients with significant bacteriuria were more frequently activating.

Blood↗
PubMed1979

An in vitro comparison of capillary flow dialyzer performances on a single needle system (double headpump).

The ultrafiltration, clearance and priming characteristics of six capillary dialyzers (C-DAK 2.5 D, C-DAK 1.8 D, Tri-Ex 1, CF M 1500, N16F160 and HF 150) were studied in single needle dialysis by way of the double headpump (BL 760, Bellco Ltd). A good control of the ultrafiltration by an appropriate choice of the mean bloodcompartment pressures (Pbo) is present in all dialyzers. After correction of the clearance for ultrafiltration the clearances of urea, creatinine, sodiumiothalamate-l125 and cyanocobalamine-Co58 (vit. B 12) rise with increasing mean pressures in the bloodcompartment of all dialyzers. We assume that a better use of available surface area due to the characteristics of the double headpump such as TMP mainly influenced by Pbo pressures and other such as tidal flow are responsible for the excellent in vitro clearances of these dialyzers with this type of single needle system.

Blood↗
PubMed1978

Shunt nephritis.

A case of nephritis occurring in a 40-year old patient with a ventriculojugular shung infected with staphylococcus albus is described. Circulating antistaphylococcal antibodies could be demonstrated. Renal manifestations disappeared after treatment with systemic antibiotics and surgical removal of the shunt.

Adult↗
PubMed1978

Serum chromatographic pattern in different dialysis strategies.

In different dialysis strategies (hemodialysis with Gambro 1.5 m2, RP6 1 m2, Vita 2 1.2 m2), sequential ultrafiltration with RP 6 (1 hour ultrafiltration followed by 3 hours of hemodialysis and hemoperfusion with Absorba 300 C) serum chromatographic pattern and medium size molecules were studied with Sephadex G 15 chromatography. The removal of the studied medium size molecules is not different from one dialyzer to another. Serum levels were generally halved by the dialysis. In the ultrafiltration fluid a considerable amount of medium size molecules was found. There is no difference between RP 6 in open or in closed system. The absorbing capacity of the Absorba 300 C was blocked after one hour for medium size molecules in the patient under study.

Chromatography, Gel↗
PubMed1977

Pharmacokinetics of nomifensine in impaired renal function.

1. In uremia, an increased frequency of adverse drug reactions is observed at elevated plasma levels of active drug. This is a consequence of decreased renal elimination of unchanged drug or pharmacologically active metabolites. 2. To study the pharmacokinetics of nomifensine in uremia, a single dose of nomifensine maleate 50 mg was given to 10 patients with a glomerular filtration rate between 0 and 61 ml/min. In three additional patients on maintenance haemodialysis, the influence of dialysis on the elimination of nomifensine after single oral doses of 50 mg was studied. 3. Blood samples were obtained before and at regular half-hourly or hourly intervals after administration. Plasma levels of nomifensine were examined using a radioimmunological determination method and pharmacokinetic parameters were calculated by computer program. 4. Whereas in healthy subjects the half-life of nomifensine was found to be 1.8 h, this parameter was found to be prolonged in renal patients. In a patient with a creatinine clearance of 0 ml/min the elimination half-life was 46 hours. Nomifensine is not eliminated by haemodialysis. 5. Our findings suggest that nomifensine should not be administered to renal patients with a glomerular filtration rate below 25 ml/minute.

Clinical Trials as Topic↗
PubMed1976

Effect of variation in dietary NaCl intake on total and fractional renal blood flow in the normal and mercury-intoxicated rat.

We studied the effect of different chronic (3-4 weeks) dietary salt intakes on intrarenal hemodynamics of normal and mercury-intoxicated rats. Cardiac output (CO), total renal blood flow (RBF), and the zonal perfusion rate in the outer cortex (OC) and inner cortex (IC) were measured by the radioactive microsphere method. The distribution of cortical blood flow was calculated as the distribution index (DI), which reflects the ratio OC/IC. Rats were placed on a high salt diet (group I), intermediate salt diet (group II), or low salt diet (group III). For each group control rats (subgroup A) and mercury-intoxicated rats (subgroup B) were studied. No effect of the different salt intakes on the DI could be detected. The DI in group IA was 2.35 +/- 0.14; in IIA, 2.40 +/- 0.16; and in IIIA, 2.38 +/- 0.09 (P greater than 0.05). After mercury injection RBF changed from 5.32 +/- 0.36 ml/g.min(-1) (IIA) to 3.31 +/- 0.20 ml/g.min(-1), IIB and from 4.32 +/- 0.11ml/g.min(-1) (IIIA) to 1.98 +/- 0.10 ml/g.min(-1) (IIIB) P less than 0.01). The DI was lowered to 1.53 +/- 0.06 (IIB) (P less than 0.05) and to 1.16 +/- 0.10 (IIIB) (P less than 0.01). In both IIB and IIIB a marked elevation of the blood urea was noted (IIB = 97 +/- 9 MG/100 ML AND IIIB = 182 +/- 25 mg/100 ml). In group IB no effect on RBF, OC, IC, or DI could be observed (for all values, P greater than 0.05) despite similar histological renal lesions. Group IB rats also had normal blood urea levels (31 +/- 6 mg/100 ml;P greater than 0.05). We conclude (1) that variations in dietary salt intake appear to have no detectable effect on the intracortical blood flow distribution; and furthermore (2) that the mercury-induced acute renal failure (ARF) is characterized hemodynamically by a total renal and preferential outer cortical ischemia and that chronic salt loading prevents the ARF while preserving normal renal perfusion.

Acute Kidney Injury↗