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Biomedical subjects

S Reiter

Publications and source records attributed to S Reiter.

At least 37 records · Page 2Linked to original sources

Curriculum renewal in child psychiatry.

OBJECTIVE: To ensure uniform design and evaluation of a clerkship curriculum for child and adolescent psychiatry teaching common disorders and problems in an efficient manner across 5 teaching sites and to include structures for continuous improvement. METHOD: The curriculum committee selected for course inclusion disorders and problems of child psychiatry that were commonly encountered by primary care physicians. Instruction methods that encouraged active student learning were selected. Course coordination across sites was encouraged by several methods: involving faculty, adopting a centralized examination format, and aligning teaching methods with examination format. Quantitative and qualitative methods were used to measure students' perceptions of the course's value. These evaluative results were reviewed, and course modifications were implemented and reevaluated. RESULTS: The average adjusted student return rate for course evaluation questionnaires for the 3-year study period was 63%. Clerks' ratings of course learning value demonstrated that the course improved significantly and continually across all sites, according to a Scheffé post-hoc analysis. Analysis of student statements from focus-group transcripts contributed to course modifications, such as the Brief Focused Interview (BFI). CONCLUSIONS: Our curriculum in child psychiatry, which focused on common problems and used active learning methods, was viewed as a valuable learning experience by clinical clerks. Curriculum coordination across multiple teaching sites was accomplished by including faculty in the process and by using specific teaching and examination strategies. Structures for continuous course improvement were effective.

Canada↗

Children's attitudes toward peers with disabilities: the Israeli perspective.

Attitudes toward peers with disabilities were compared in two groups of elementary school children, Israeli (2845 children) and Canadian (1831 children), using the Chedoke-McMaster Attitudes Toward Children with Handicaps (CATCH) scale. Israeli children expressed significantly more positive general attitudes (P=0.0001). The more favourable attitudes were seen in both areas evaluated by the CATCH, the cognitive and the affective-behavioural. In both groups, children who had had previous experience with a disabled person expressed more positive attitudes (P=0.001). An effect of gender was seen in the Canadian but not in the Israeli children. Cultural factors appear to play a role in modelling children's attitudes toward their disabled peers and therefore should be considered before educational programmes are implemented.

Attitude↗

Preschoolers' responses to ongoing interadult conflict: the role of prior exposure to resolved versus unresolved arguments.

Children's past experiences with interadult conflict are likely to influence their responses to ongoing arguments. Preschoolers' (4- to 5-year-olds) responses to interadult conflict were examined as a function of experimentally manipulated histories of exposure to resolved and unresolved arguments. Children were presented with two live arguments that were either resolved or unresolved, then they were presented with a third argument that was interrupted in progress (i.e., unresolved), and they were interviewed next. Children's overt-behavioral responses were videotaped and coded for distress level. The results support the notion that past experiences with conflict resolution ameliorate children's distress responses to ongoing arguments. In comparison to children previously exposed to unresolved conflict, those exposed to a history of resolved disputes were more likely to (a) exhibit lowered behavioral distress, (b) predict a lower likelihood of a conflictual outcome for the couple's argument, (c) report less negative perceptions of the arguing adults, and were less likely to (d) endorse intervention in conflict through attempts to stop the disputes; (c) and (d) pertained only to girls.

Adult↗

Transition from school to work of students with developmental disabilities and mental retardation: an Israeli perspective.

The present research was conducted in four special education schools for students with developmental disabilities and mental retardation in the Haifa area. The total number of subjects was 72. There were 45 (63%) males and 27 (37%) females. The mean age was 18.1 years (range: 16-19.5). The mean IQ (WISC) was 66.3 points (range: 40-85). The vocational placement at the end of 6 months after leaving school was recorded for each school graduate. A total of 53 teachers--school principles, counsellors, specialized teachers and speech and occupational therapists--filled out specially designed questionnaires covering three areas: (1) students' work programme experience; (2) teachers' ratings of final year students on: academic studies, social behaviour, independence and vocational skills as well as teachers' recommendations, given towards the end of the final year at the school, for the immediate plan of action for each of the graduating students; (3) teachers' ratings of parental involvement with the educational programme of each student. Background variables included IQ, age and gender. The major finding was that 6 months after graduation, one-third of special school graduates were not working, were not enrolled in any formal programme and were idle at home. The variables that were found to correlate with successful placement were students' prior work experience, teachers' ratings of students achievements and their recommendations for each student, and parental involvement.

Adolescent↗

The self-employment option for people with disabilities: a case study of 'AHVA' desk top publishing company.

From the above results of the evaluation survey it can be concluded that the participants of the 'AHVA' desktop publishing company, who are with multiple and physical disabilities and who have initiated and run their own enterprise, perceived their first year of operation as beneficial. They mastered new technical skills, learned new work-related behaviours, expanded their interpersonal competencies and felt personal growth. They all developed high motivation to make their operation successful. The case study of 'AHVA' desktop publishing company, initiated and run by a group of multiply and physically disable persons, is unique and demonstrates the positive trend for the future. It is an example of personal and group commitment to build a competitive enterprise. It is self determination rather than the actual outcome of services provided, that is the driving force behind their efforts. The team members demonstrated that persons with disabilities can indeed take charge of their lives, be masters of their own destinies, and lead a productive and meaningful life. Here, inclusion is not a one-sided process in which service providers and rehabilitation experts try to integrate persons with disabilities into the community and regular employment. Inclusion is to integrate persons with disabilities into the community and regular employment. Inclusion is achieved here by the self initiative of a group of persons with disabilities. They have created an extraordinary enterprise according to their own special needs. Non-disabled people interact with them on an equal level, as partners in a business, sharing mutual interests of quality production.(ABSTRACT TRUNCATED AT 250 WORDS)

Behavior↗

The successful pharmacological treatment of adolescents and young adults with borderline personality disorder: a preliminary open trial of flupenthixol.

Borderline personality disorder is a significantly disabling disturbance often arising in adolescents or young adults. In the absence of demonstrated effective treatments in this population, this open prospective study evaluated the effect of low dose (3 mg per day) flupenthixol in 13 rigorously diagnosed adolescents with borderline personality disorder. Therapeutic outcome over eight weeks of treatment assessed across measures of impulsivity, depression/dysphoria, general psychopathology and global functioning showed significant improvement in all spheres. These findings suggest that low dose flupenthixol may have a role to play in the short-term treatment of this population.

Adolescent↗

A decentralized process for finding equilibria given by linear equations.

I present a decentralized process for finding the equilibria of an economy characterized by a finite number of linear equilibrium conditions. The process finds all equilibria or, if there are none, reports that, in a finite number of steps at most equal to the number of equations. The communication and computational complexity compare favorably with other decentralized processes. The process may also be interpreted as an algorithm for solving a distributed system of linear equations. Comparisons with the Linpack program for LU (lower and upper triangular decomposition of the matrix of the equation system, a version of Gaussian elimination) are presented.

Journal Article↗

Preparation and central action of propofol/hydroxypropyl-beta-cyclodextrin complexes in rabbits.

Inclusion complexes of propofol (CAS 2078-54-8) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were examined in aqueous solution and in the solid state by phase solubility technique, IR-spectroscopy and differential scanning calorimetry. Solid complexes obtained by kneading method were dissolved in artificial plasma leading to a colloidal solution which was suitable for intravenous administration. In the in vivo studies propofol (15 mg/kg) was given intravenously to rabbits in equimolar doses as cyclodextrin complexes and as Diprivan. The central action of the drug was verified by recording the bioelectrical activity of the precentral cortex. The statistical evaluation of the results do not indicate differences in onset, duration and maximum of action between the two dosage forms.

Animals↗

Simultaneous determination of allopurinol and oxipurinol in human plasma and urine by high-performance liquid chromatography.

The uricostatic drug allopurinol (CAS 315-30-0) is used for treatment of hyperuricaemia and is mainly bio-transformed to the active metabolite oxipurinol (CAS 2465-59-0) in humans. A new assay was developed for the simultaneous determination of both compounds in plasma and urine using ultrafiltration and ion exchange purification steps for plasma and urine, respectively. Reversed-phase high-performance liquid chromatography with ultraviolet detection was applied for the separation and quantitation of both compounds. The limit of detection was 0.1 microgram/ml for both compounds in plasma and 0.2 and 0.5 microgram/ml for allopurinol and oxipurinol, respectively, in urine. Within-run and day-to-day precision of 3-5% and 5-7% was determined for plasma and 6-8% and 8-10% for urine analysis. The assays were further validated using liquid chromatography with photodiode array detection and by comparison with methods using protein precipitation as the purifying step. The high analytical recoveries, selectivity, sensitivity, accuracy and reproducibility were adequate for the measurement of both compounds in pharmacokinetic studies and for drug monitoring in patients on allopurinol therapy.

Adult↗

High-dose fluoxetine in the treatment of depressed patients not responsive to a standard dose of fluoxetine.

In a four-week, open label study of major depression, 15 patients who had failed to respond to a trial of fluoxetine 20 mg/day of 8-12 weeks duration were then treated with fluoxetine 40 mg/day for one week and then, if tolerated, with either 60 or 80 mg/day. The mean HAM-D-17 and CGIS scores of these 15 patients decreased significantly at the end of 4 weeks on a higher dosage of fluoxetine (60 or 80 mg/day) with respect to the beginning of the four-week study. No significant side-effects were noted.

Adolescent↗

Anxiety disorders in children and adolescents: clinical and related issues in pharmacological treatment.

Anxiety disorders in children and adolescents are receiving more attention from clinicians and researchers. Psychopharmacological approaches to controlling symptoms of anxiety are possible as part of a multi-model treatment approach. This paper provides an overview of some recent findings in child and adolescent anxiety disorders that may influence treatment decisions. It also reviews studies of the use of benzodiazepines and tricyclic antidepressants in treating children and adolescents who suffer from anxiety disorders, and suggests methods of integrating pharmacological treatment with other modalities in these disorders.

Adolescent↗

Genitourinary and sexual adverse effects of psychotropic medication.

OBJECTIVE: We review the adverse effects on genitourinary and sexual function associated with antidepressants, neuroleptics, lithium, and benzodiazepines, and suggest treatment strategies that may be used for their management. METHOD: This article is based on systematic review of the existing literature, including more than 130 relevant articles on genitourinary and sexual effects of psychotropic medications. RESULTS: We find that genitourinary function, including effects on continence and flow, and sexual function, including libido, erection, ejaculation and orgasm, may be altered by psychotropic administration. Many of these effects may be consequent to the impact of these medications on neurophysiologic systems. CONCLUSIONS: Genitourinary and sexual adverse effects associated with psychotropic therapy are important areas of study and clinical concern that may affect patient comfort and compliance with treatment.

Antidepressive Agents↗

The pharmacotherapy of anxiety disorders in children and adolescents.

Psychopharmacologic agents may offer potentially effective treatment of child and adolescent anxiety disorders. Much further research, however, remains to be done to determine medication specificity, dosages, duration of treatment, and the optimal relationship between pharmacologic and nonpharmacologic therapies.

Adolescent↗