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Biomedical subjects

S Rasmussen

Publications and source records attributed to S Rasmussen.

At least 235 records · Page 13Linked to original sources
PubMed1979

Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study.

Ninety-eight patients with metastatic breast cancer, heavily pretreated with other agents, were entered in a phase II trial of hexamethylmelamine (HEX). Patients were randomized to receive HEX alone or combined with prophylactic pyridoxine. There was a 2% response rate in 89 partially or fully evaluable patients. Seven percent of these patients developed neurologic toxicity which occurred in the HEX-alone group only.

Aged↗
PubMed1979

Short-term prognostic index in acute myocardial infarction. Multivariate analysis by Cox model.

A new multivariate stepwise linear regression analysis (Cox's model) with survival time as prognostic endpoint was utilized in 281 patients with acute myocardial infarction. From 18 prognostic factors occurring during the first 5 days in the Coronary Care Unit a new prognostic index was calculated for the chance of survival in the first 36 days after admission. The significant prognostic variables were heart failure, cardiogenic shock, atrioventricular block and age. The total group of patients was classified in 6 subgroups with different mean indices and prognosis. There were 2 large groups of patients with relative bad and good prognosis (with and without heart failure). Over half of the patients had no prognostic variables. There was a trend of overestimating the expected deaths. A definite cardiac cause of death was shown by 23 patients (82%). This prognostic index based on the 4 variables can for the individual patient predict the chance of survival, which can be the basis of an individualized duration of hospital stay.

Age Factors↗
PubMed1978

Effect of labetalol on plasma noradrenaline and adrenaline in hypertensive man.

Injection i.v. of labetalol, a new adrenergic alpha- and beta-blocking agent, decreased arterial blood pressure in 9 hypertensive subjects resting in the supine position, when standing and during supine exercise. Heart rate after labetalol was unchanged in the resting supine position, and it fell in the latter two conditions. Plasma noradrenaline concentration was higher after labetalol in all three experiments as compared to a control study. Plasma adrenaline after labetalol was increased only in the standing position, when the highest plasma noradrenaline concentrations were observed. Blood glucose concentration tended to increase after labetalol, but the difference was not statistically significant. The changes in plasma noradrenaline and blood glucose after labetalol mimic findings observed after alpha-adrenergic receptor blockade. The beta-adrenergic receptor blocking property of labetalol is responsible for the reduced heart rate and it is likely to contribute to the higher plasma noradrenaline concentration observed when standing and during supine exercise.

Adult↗
PubMed1978

Coronary heart disease--a possible risk in megavoltage therapy?

A 21-year old man died of an extensive anteroseptal myocardial infarction 16 months after receiving megavoltage radiotherapy to a mantle field for Hodgkin's disease stage PS IA confined to the midcervical lymph nodes on the left side of the neck. Post mortem findings revealed severe atherosclerotic changes in the coronary arteries. This case and a review of the literature suggest that irradiation to the heart may induce or accelerate atherosclerosis of the epicardial vessels. This should be taken into consideration when starting prophylactic irradiation to the mantle field in patients with Hodgkin's disease stage IA without obvious involvement of the mediastinun. Histologic examination of the heart and coronary vessels should be performed in any fatal case after megavoltage therapy involving the heart.

Adult↗
PubMed1978

Sensitive delusion of reference, "sensitiver Beziehungswahn". Some reflections on diagnostic practice.

Ten patients discharged with the diagnosis of "sensitiver Beziehungswahn" were followed up 22--28 years after their discharge. In one case, the course of the illness indicates that the patient suffered from a manic-depressive psychosis, and in two cases, this diagnosis was likely. In two cases the disorder seemed definitely to be schizophrenia. One case was presumably a transient paranoid reaction. One patient was likely to have suffered from hysteria or epilepsy, three cases remained uncertain. The study did not prove suitable in the evaluation of the validity of "sensitiver Beziehungswahn" as a nosological entity, since at the time of diagnosis the patients only incompletely fulfilled the criteria set up the Kretschmer, but it throws light on the diagnostic practice and the tendency to a change between the classification into many independent disease entities and the subsequent inclusion into larger and fewer forms.

Adult↗
PubMed1978

Ipsilateral limb variation in cats during overground locomotion.

The timing interval between the onset of knee extensor EMG (vastus lateralis) and the onset of the ipsilateral elbow flexor EMG (brachialis) was studied in adult cats during overground walking, trotting and galloping. Concurrent finding of the animals in locomotion was used to relate the electrical activity of the muscles to the physical events in a step cycle. The observed variability in the interval between the onset of knee extensor EMG and the onset of elbow flexor EMG lead to the conclusion that it is not appropriate to postulate a rigid neural coupling mechanism for the control and coordination of ipsilateral limbs in locomotion.

Animals↗
PubMed1978

Detection of myocardial scar tissue by M-mode echocardiography.

Wall thicknesses were measured and echo densities were evaluated from the left ventricular echograms of 182 patients. The echogram was considered to reflect scar tissue when 1) either the interventricular septum, the posterior left ventricular wall or the anterior left ventricular wall was less than 7 mm thick in mid-diastole and was more echo-producing than its opposing wall or another area of the same wall in a sector scan, or 2) an area of myocardium was 30% less thick than an adjacent area within a sector scan. Myocardial scarring was diagnosed by echocardiography in 52 of the 182 patients. The echocardiographic presence or absence of scarring was confirmed in 95% (173 of 182) of cases, 34 cases by microscopic examination and 139 by surgical appearance. This study shows that M-mode echocardiography is both a sensitive and specfic method for detecting myocardial scar tissue.

Coronary Angiography↗
PubMed1978

Stroke volume calculated from the mitral valve echogram in patients with and without ventricular dyssynergy.

A formula was derived for calculating mitral valve stroke volume (MVSV) using the rate of mitral valve (MV) opening (DE slope on the MV echogram), the vertical disease between the mitral leaflet echoes early in diastole (EE), the electrocardiographic PR interval and heart rate. The formula was tested prospectively on 80 consecutive patients from whom 95 simultaneous MV echograms and either thermodilution (45) or Fick (50) cardiac outputs were obtained. Sixteen patients were normal; 54 had coronary artery disease; three had cardiomyopathy; and seven had nonrheumatic mitral regurgitation (MR). Linear regression for stroke volume was r = 0.90, SEE +/- 6, and for cardiac output r = 0.83, SEE +/- 0.5 liter for the 73 patients without MR. The presence or absence of ventricular dyssynergy did not alter statistical findings. MVSV consistently overestimated forward stroke volume for the seven patients with MR. This study shows that the MV echogram provides an accurate, widely applicable method for calculating MVSV.

Cardiac Catheterization↗