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Biomedical subjects

S Rashid

Publications and source records attributed to S Rashid.

At least 73 records · Page 4Linked to original sources
PubMed1990

An evaluation of the acute in vivo toxicity of benzylidenechroman-4-ones, 1-thiobenzylidenechroman-4-ones and benzylidenetetralones.

A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antifungal agents. These compounds were found to be less toxic, as judged by acute toxicity, than existing commercially available antifungals. A number of conclusions can be drawn about the relationship of structural changes in this series of compounds to increases or decreases in acute toxicity.

Animals↗
PubMed1988

Evaluation of community-based rehabilitation in Punjab, Pakistan: I: Use of the WHO manual, 'Training disabled people in the community'.

The WHO community-based rehabilitation programme has been tested in a village and a slum area in Pakistan. House-to-house surveys by physicians identified medical diagnoses and impairments and handicaps according to the ICIDH. Volunteer local supervisors from the communities were taught to identify and train disabled persons according to the CBR manual. The effect of training was evaluated after 1-2 years by an occupational therapist, using questions from the same manual. Of the 82 persons followed up, 80% showed improvement in function. The prevalence of disablement identified by the local supervisors and of handicap identified by a physician agreed well, and was of the order of 5%.

Community Health Services↗
PubMed1988

Evaluation of community-based rehabilitation in Punjab, Pakistan: II: The prevalence of diseases, impairments, and handicaps.

A health survey using the impairment and handicap classifications from the ICIDH was carried out in conjunction with a study of the WHO community-based rehabilitation programme in a village and a slum area in Pakistan. The prevalence of handicaps defined in this way was about half that of impairments, the most common handicaps being with mobility, occupation, and social integration. There was a slightly higher degree of handicap in the village. In both areas diseases of the musculoskeletal system, the ear, and the respiratory tract were common, but the frequency of infectious, respiratory, endocrine, blood, and digestive diseases was higher in the slum area.

Community Health Services↗
PubMed1988

Changes in e.C.g. And electrolytes during coronary ligation in anaesthetized cat.

The ligation of the coronary artery produces cardiac, and haemodynamic disturbances. Electrolytes disturbances were also noted during the assault (Harris et. al., 1954). In present experiments local cardiac ischaemia was produced by coronary ligation and changes in E.C.G. and electrolytes were noted at various stages. Pre-mature ventricular systoles and T wave inversion with an increase in K+ and decrease in Na+ was observed.

Journal Article↗
PubMed1987

Malthus's Essay on Population: the facts of "super-growth" and the rhetoric of scientific persuasion.

For the Malthusian theory of population to be accepted as "scientific," it was essential that the theory be established on wide empirical evidence. A close examination of the "facts" provided by Malthus, however, shows that many of his crucial facts are based on distortions of the available evidence. Malthus was probably aware of much of this weakness, but for rhetorical reasons he persisted with the sandy empirical foundations from which he began.

Economics↗
PubMed1986

Topical treatment of recurrent genital herpes simplex virus infections with trisodium phosphonoformate (foscarnet): double blind, placebo controlled, multicentre study.

A double blind, placebo controlled trial was performed in nine sexually transmitted diseases (STD) clinics in the United Kingdom and the Netherlands to investigate the efficacy of trisodium phosphonoformate (foscarnet) cream in treating recurrent genital herpes simplex virus (HSV) infection. The study group comprised 145 male and 85 female patients. Men received 0.3% foscarnet cream and women 1% foscarnet cream for five days. The difference in time to healing between patients receiving foscarnet or placebo was not significant. Fewer patients treated with foscarnet had positive viral cultures after treatment, but the difference was not significant. The development of new lesions, however, was significantly less common in patients given foscarnet. Though topical foscarnet is a safe drug, no appreciable efficacy in treating recurrent genital HSV infection could be shown.

Administration, Topical↗
PubMed1986

Declaring cure in women with gonorrhoea.

The case notes of 426 women who had been treated for uncomplicated gonorrhoea in 1978-83 inclusive, were studied. The findings for 1978 formed a retrospective basis for a prospective study. The aim was to appraise the value of earlier and fewer follow up tests of cure. The new routine was associated with a more assertive approach to other modalities of control. It was concluded that the interests of individual patients, as well as those aimed at control, were adequately served by one set of smear and culture specimens. There was one proviso. Potential "repeaters" need to be identified and treated individually in terms of follow up testing.

Anti-Bacterial Agents↗
PubMed1981

Cardioregulatory properties of indoramin in the rat.

The antihypertensive action of the competitive alpha-adrenoceptor antagonist indoramin is not accompanied by reflex tachycardia in animals or man. The possibility that the established local anaesthetic property of indoramin is involved in its cardioinhibitory action has been investigated. Indoramin evoked a dose-dependent bradycardia in anaesthetized/pithed rats. The decrease in heart rate was slightly greater than that evoked in anaesthetized intact animals suggesting that indoramin had a direct action on the heart. Reflex tachycardia was simulated in pithed rats be increasing the frequency of cardiac nerve stimulation from 0.3 to 1 Hz. Indoramin and the local anaesthetic agents, lignocaine and procaine, reduced the positive chronotropic response without markedly altering the basal rate. The response curves were parallel. In contrast, phentolamine decreased the positive chronotropic response, but only at high doses which were associated with a marked decrease in the basal rate. Thymoxamine and prazosin had so significant effects on the chronotropic response. These experiments suggest that the cardioregulatory action of indoramin is attributable to its local anaesthetic property had this action further distinguishes it from the other alpha-adrenoceptor antagonists tested.

Adrenergic alpha-Antagonists↗