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Biomedical subjects

S Rani

Publications and source records attributed to S Rani.

At least 73 records · Page 4Linked to original sources
PubMed1981

Synergism, antagonism, and additivity of phenol, pentachlorophenol, and dinitrophenol to a fish (Notopterus notopterus).

The toxicity of phenol (P), pentachlorophenol (PCP), and dinitrophenol (DNP) was determined separately and in different combinations with a test fish, Notopterus notopterus, using the procedure of Schubert et al. (1978) that provided a simple, sensitive, and quantitative index of synergism, antagonism and additivity. The combination (P + DNP)/PCP was found to be the most synergistic, while (PCP + DNP)/P was antagonistic in nature. The (DNP + P)/PCP combination was additive in its effect. The other combinations were also synergistic, but to a lesser extent than the (P + DNP)/PCP combination.

Animals↗
PubMed1981

Pesticide-induced physiological alterations in certain tissues of a fish, Mystus vittatus.

Effect of sublethal concentrations (1/5, 1/10 and 1/15 fractions of 96-h TL50) of thiotox, dichlorvos and carbofuran on acid, alkaline and glucose-6-phosphatase of liver, kidney and gills of Mystus vittatus have been studied. Maximum (62.79%) inhibition of alkaline phosphatase in gills after thiotox (0.00013 mg/l) treatment have been observed. At 0.000045mg/l concentrations of thiotox, a marginal (7.6%) and significant (P less than 0.01) stimulation was observed in hepatic alkaline phosphatase activity.

Acid Phosphatase↗
PubMed1981

Isolated and combined effects of pesticides on serum transaminases in Mystus vittatus (African catfish).

Alterations in serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels of Mystus vittatus (African catfish) after exposure to subacute concentrations of thiotox (T), dichlorvos (D), and carbofuran (C) and their combinations C/T (antagonistic), T/D (additive) and (T + D)/C (synergistic) for a period of 30 days have been investigated. Alterations were more evident in SGOT than in SGPT. Maximum (92.5%) elevation was observed with SGOT at the highest concentration of (T + D)/C combination and the lowest (14.76%) at the lowest concentration of T/D combination. Significant (P less than 0.05) stimulation was observed except at the lowest concentration after all treatments.

Alanine Transaminase↗
PubMed1981

Effect of phenolic compounds on in vivo activity of glucose-6-phosphatase in certain tissues of Notopterus notopterus.

The effects of phenol (P), dinitrophenol (DNP), pentachlorophenol (PCP), and their three combinations--(PCP + DNP)/P (highly antagonistic), (DNP + P)/PCP (additive) and (P + DNP)/PCP (highly synergistic)-- on glucose-6-phosphatase activity in liver, brain, kidney and gills of Notopterus notopterus were studied at three sub-acute concentrations (1/10, 1/15 and 1/20 the fraction of the 96-h LC50) after 15 and 30 days of exposure. When these chemicals were used separately, PCP exerted more effect than DNP and P. Maximum (71.56%) and highly significant (P less than 0.001) inhibition was observed in liver at the highest concentration of (P + DNP)/PCP combination after 30 days exposure, and lowest (3.64%) and insignificant inhibition in kidney at 1/20 of the (PCP + DNP)/P combination after 15 days exposure. Significant (P less than 0.05, P less than 0.01) stimulation in kidney or no effect in other tissues was observed in lower concentrations of P, DNP and (PCP + DNP)/P.

2,4-Dinitrophenol↗
PubMed1981

Effects of phenolic compounds on in vivo blood parameters of a fish Notopterus notopterus.

Effects of phenol (P), dinitrophenol (DNP), pentachlorophenol (PCP) and their three combinations, antagonistic [(PCP + DNP)/P], additive [(DNP + P)/PCP] and synergistic [(P + DNP)/PCP], at three subacute concentrations (1/10th, 1/15th and 1/20th fractions of 96 h LC50) were determined on several blood parameters after 30 days exposure taking Notopterus notopterus as a test fish. Generally, RBC, WBC and PCV were found to be increased while CT, ESR, Hb, MCH, MCHC and MCV were decreased. However, PCP showed dual effects in many cases. CT and MCV were decreased in PCP alone and in (DNP + P)/PCP combination, while increased in (P + DNP)/PCP combinations while decreased in PCP alone. Again RBC and MCV were decreased/increased in DNP alone. Significance of findings is that these haematological parameters can be used as scientifically most accurate are reliable laboratory diagnostic indices by fish breeders, administrators and scientists as to know the state of health of fish population and to make warning about deleterious effects of phenolic compounds so that appropriate measure may be taken by all concerned to protect a valuable source of human food.

2,4-Dinitrophenol↗
PubMed1980

Effects of phenol and dinitrophenol on acid and alkaline phosphatases in tissues of a fish (Notopterus notopterus).

Specimens of a fresh water fish, Notopterus notopterus were exposed to either phenol (12.56 mg/L), dinitrtophenol (1.34 mg/L), or a mixture of the two (6.28 mg phenol + 0.67 mg dinitrophenol/L) for 72-hr. Surviving fish were sacrificed at 24-, 48-, and 72-hr after exposure, and tissue samples were taken for determining the acid phosphatase and alkaline phosphatase activities. Phenol, dinitrophenol, and mixtures of both, inhibited the activity of both enzymes in the kidney, heart, brain, gills, muscles, stomach, intestine, and pyloric caeca. dinitrophenol exerted more inhibition than phenol. In general, mixtures of phenol and dinitrophenol are somewhat more effective than either compound alone in the inhibition of enzyme activities.

Acid Phosphatase↗
PubMed1980

Uhl's anomaly with rudimentary pulmonary valve leaflets: a clinical, hemodynamic, angiographic, and pathologic study.

An acyanotic 4-year-old male child who failed to thrive presented with signs of persistent right heart failure and no cardiac murmurs. There was radiologic evidence of gross cardiomegaly with unremarkable lung fields. Cardiac catheterization and cineangiographic features helped in arriving at the diagnosis of parchment right ventricle with normal tricuspid valve (Uhl's anomaly), a rare condition seldom diagnosed during life. The patient was subjected to surgery, and Glenn's operation was performed, following which he died of a low output state and bradyarrhythmia. Autopsy revealed partial parchment right ventricle with rudimentary pulmonary valve leaflets, a combination not described previously.

Child, Preschool↗
PubMed1980

In vivo subacute physiological stress induced by phenolic compounds on acid and alkaline phosphatases in serum of a fish, Notopterus notopterus.

The in vivo effects of phenol (P), dinitrophenol (DNP), pentachlorophenol (PCP), and their combinations--antagonistic [(PCP + DNP)/P], additive [(DNP + P)/PCP] and synergistic [(P + DNP)/PCP] [18]--on acid and alkaline phosphatases in serum of Notopterus notopterus have been studied at three subacute levels (1/10, 1/15 and 1/20 of 96-h LC50) after 15 and 30 days of exposure. Stimulation in acid phosphatase was more pronounced than in alkaline phosphatase when the fish were exposed to P, DNP, PCP and (P + DNP)/PCP for both time intervals. In (PCP + DNP)/P and (DNP + P)/PCP, however, the stimulation was greater in alkaline phosphatase.

Acid Phosphatase↗