Search PubMed⌕ Search

Biomedical subjects

S Rani

Publications and source records attributed to S Rani.

At least 55 records · Page 3Linked to original sources
PubMed1990

B cell lymphoma of the thyroid in Hashimoto's thyroiditis monitored by fine-needle aspiration cytology.

An 80-yr-old female with a grade I diffuse goiter was diagnosed on fine-needle aspiration cytology as having Hashimoto's thyroiditis. Two years later, she developed a hard nodular growth in the right lobe of the thyroid, which was subjected to fine-needle aspiration and diagnosed as a non-Hodgkin's lymphoma. Immunocytology demonstrated the monoclonal B cell nature of the lesion. The patient underwent total thyroidectomy and is alive and free of the disease 27 mo after surgery.

Aged↗
PubMed1990

Pure red cell aplasia.

Eleven cases of Pure red cell aplasia (PRCA) in children were encountered in our hospital since 1982. The age range was 4 months to 12 years. There was a male preponderance with M:F ratio as 9:2. There were 4 cases due to viral fever, 1 with bronchopneumonia, 2 of tuberculosis, 1 of enteric, 1 of NHL and 2 were of congenital PRCA. Tuberculosis per-se had given rise to PRCA in the two cases, which is not reported earlier though its association with anti-tubercular therapy is well recorded. Cases of infective etiology other than viral responded very well to specific treatment. Steroid was the drug of choice in PRCA with viral etiology.

Child↗
PubMed1988

Early expression of MCS2 (CD13) in the cytoplasm of blast cells from acute myeloid leukaemia.

The expression of two myeloid antigens identified by the monoclonal antibodies (McAb) MCS2 (CD13) and MY9 (CD33) was investigated in 136 cases of leukaemia. MCS2 was positive in blast cells of 78 of 88 (88.5%) and MY9 in 51 of 81 (64%) cases of acute myeloid leukaemia (AML) and chronic granulocytic leukaemia in myeloid blast crisis. One or other McAb, or both, were positive in all but 2 (2.3%) of these cases. MCS2 was more sensitive than MY9 to detect blasts of the myeloid lineage due to its most frequent reactivity in the cytoplasm of fixed cells by the immunoperoxidase (IP) technique compared with its membrane expression on cell suspensions by immunofluorescence (IF). MY9 was not suitable for tests on fixed cells. MCS2 was positive by IP but not by IF in 24% of AML, but the reverse was not observed. This suggests that the antigen detected by MCS2 is expressed in myeloblasts first in the cytoplasm and later on the cell membrane, pattern which is similar to that of the early antigens CD3 and CD22 in T and B lineage lymphoblasts, respectively. MCS2 was always positive in FAB types of AML-involving myeloblasts (M1-M4), including cases of undifferentiated morphology (M0), whilst MY9 was more frequently positive in monocytic leukaemia (M5). On the other hand, MCS2 was positive in 4 of 33 cases of acute lymphoblastic leukaemia and MY9 in 1. We conclude that both McAb, particularly MCS2, contribute to the better characterisation of myeloid leukaemias but that other tests are required to clarify the nature of the blasts when unexpected reactivities are observed.

Antibodies, Monoclonal↗
PubMed1988

Different expression of CD3 and CD22 in leukemic cells according to whether tested in suspension or fixed on slides.

The expression of antigens detected by monoclonal antibodies of the CD22 and CD3 groups was studied, by immunofluorescence (IF) on cell suspension and by immunoperoxidase (IP) on cells fixed on cytospin slides, in a range of B- and T-cell malignancies. CD22 was demonstrated in the B-cell leukemias more frequently by IP than by IF; in B-lineage acute lymphoblastic leukemia (ALL) it was positive only by IP. In chronic lymphocytic leukemia and lymphoplasmacytic tumors approximately 40% of cases were CD22 positive by IP but few by IF. In other disorders of mature B cells, CD22 was positive by both methods in most cases. CD3 was demonstrated by IP in all 48 cases of T-cell leukemia and lymphoma regardless of the maturation stage (i.e., from early thymic to mature T cells). This was not the case by IF, where only 16% of T-ALL and 73% of cases with postthymic T-cell leukemias were recorded as positive. The greater reactivity of CD3 and CD22 by IP reflect the early cytoplasmic expression of the antigens in immature T and B cells, respectively, as well as the possible greater sensitivity of the IP method. These differences should be taken into account when describing results in lymphoid malignancies. CD3 was not expressed in cells from any of the B-cell leukemias, and likewise, CD22 was not demonstrated in any of the T-cell disorders, confirming that both reagents are highly specific for their respective lineages.

Antibodies, Monoclonal↗
PubMed1986

Adsorption thermodynamics of carbofuran on antimony (V) silicate cation exchanger.

The adsorption thermodynamics of carbofuran has been studied on antimony (V) silicate cation exchanger at 30 and 50 degrees C. The adsorption isotherms of carbofuran have been found to follow the Freundlich adsorption model and yield "S" class isotherms. The order of adsorption of carbofuran is in accordance with the partial molal free-energy changes in the exchanger. The thermodynamic equilibrium constant (K0), standard free energy (delta G degrees), enthalpy (delta H degrees), and entropy (delta S degrees) changes have also been calculated for predicting the nature of adsorption.

Adsorption↗
PubMed1985

Adsorption thermodynamics of carbofuran on sandy clay loam and silt loam soils.

The adsorption of carbofuran on sandy clay loam and silt loam soils has been studied at 30 and 50 degrees C. Adsorption data for both soils are in close agreement with the Freundlich isotherms and yield "S" class isotherms. The order of adsorption of carbofuran is in accordance with the partial molal free energy changes and conforms to the mobility of carbofuran in different soils. The thermodynamic constant (K0) and standard free energy (delta G degrees), enthalpy (delta H degrees), and entropy changes (delta S degrees) have also been calculated for predicting the nature of adsorption.

Adsorption↗
PubMed1983

Pesticide-induced dysfunction in carbohydrate metabolism in three freshwater fishes.

In the present investigation, the effect of sublethal fractions (1/4th, 1/8th and 1/16th of 96-hr LC50) of thiotox and dichlorvos on blood glucose, lactate, and liver and muscle glycogen levels of Clarias batrachus, Saccobranchus fossilis, and Mystus vittatus, exposed for 30 days, have been studied. It was observed that blood glucose and lactate levels increased from 29.13 to 98.36% and from 10.88 to 36.36%, respectively. The liver and muscle glycogen decreased from 22.99 to 69.30% and from 5.19 to 32.19%, respectively. The reasons for this carbohydrate imbalance have also been suggested.

Animals↗
PubMed1982

Effects of sodium pentachlorophenate on enzymes of energy metabolism in tissues of Notopterus notopterus.

Effect of sublethal concentrations (0.0083, 0.0055, 0.0041, 0.0033 and 0.0028 mg/l) of sodium penta-chlorophenate (Na-PCP) on the enzymes SDH, PDH and LDH in brain, liver and gills of Notopterus notopterus after 15 ad 30 days exposure were studied. SDH and PDH were inhibited, and LDH were stimulated significantly at most concentrations. However, changes were maximum (-68.3%, -73.4% and +197.7% for SDH, PDH and LDH, respectively) in brain after 30 days, and minimum (-1.3% and +2.4% for SDH and LDH, respectively) in gills and (-3.4% for PDH) brain after 15 days. Inhibition of SDH and PDH, and the stimulation of LDH activity indicate the development of anaerobic conditions at the cellular level in pollutant-stressed fish.

Animals↗