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Biomedical subjects

S R Seiff

Publications and source records attributed to S R Seiff.

70 records · Page 4Linked to original sources
PubMed1986

Cavernous hemangioma of the lacrimal fossa.

A 56-year-old woman presented with proptosis of the left eye for over 1 year. The clinical presentation and computerized tomographic scan findings were consistent with a benign mixed lacrimal gland tumor. An extensive excision of the tumor was planned through a lateral orbitotomy with bone flap. After construction of the bone flap, the clinical appearance of the tumor was not consistent with a benign mixed lacrimal gland tumor. Frozen section pathology was interpreted as cavernous hemangioma. A simple excision of the tumor with preservation of the lacrimal gland was performed. It is emphasized that benign mixed lacrimal gland tumors require extensive excision to prevent recurrence. However, other tumors may have a similar clinical presentation, as in this case, and the surgeon must consider this possibility prior to performing radical surgery.

Blepharoptosis↗
PubMed1986

Central retinal artery occlusion associated with periocular corticosteroid injection for juvenile hemangioma.

Intralesional corticosteroid injections are an accepted treatment for periocular juvenile hemangiomas. This treatment is felt to be relatively free of complications. We report, however, a case of central retinal artery occlusion associated with steroid injection for a periocular juvenile hemangioma in a four-year-old child. It is presumed that the force of injection or digital massage caused retrograde arterial flow, moving steroid suspension particles into the central retinal artery where vascular occlusion occurred. As a result of this case, our treatment regimen has been modified. We now use 0.1 cc steroid alloquats injected slowly through a 30-gauge needle and avoid firm digital pressure on the lesion.

Adrenal Cortex Hormones↗
PubMed1986

Orbital extension of uveal melanoma.

Extrascleral extension of an intraocular melanoma rarely presents as an orbital mass. Three such cases are reported. Two were in orbits with blind eyes. All three underwent exenteration and postoperative radiation. Two of three subsequently died of metastatic disease. The possibility of tumor dissemination by the operative exenteration is explored. The importance of routine tumor surveillance in blind eyes is emphasized.

Aged↗
PubMed1985

Surgical treatment of punctal-canalicular fibrosis from 5-fluorouracil therapy.

5-Fluorouracil (5-FU) has been reported to cause punctal-canalicular fibrosis with resultant severe epiphora. It is reported that the epiphora will often resolve when treatment ceases or is decreased. However, this report describes a case of punctal-canalicular fibrosis so severe that bilateral conjunctivodacryocystorhinostomies were necessary. This has not been previously reported to the best of the authors' knowledge. It is recommended that ophthalmic consultation be obtained for patients in whom long-term 5-FU therapy is anticipated or who develop tearing while on therapy.

Aged↗
PubMed1985

The use of botulinum toxin in blepharospasm.

Twenty-two patients, 17 with benign essential blepharospasm and five with hemifacial spasm, received botulinum toxin by subcutaneous injections in the eyelids and eyebrows. All 22 patients received a standard treatment of 12.5 units of botulinum toxin per side at each injection session. The orbicularis oculi muscle showed pronounced weakness after injection and the spasms decreased. Spasms often recurred despite persistent orbicularis oculi muscle weakness. Side effects were minimal. All patients received some relief, which generally lasted six to 12 weeks.

Blepharospasm↗
PubMed1984

Computed tomographic evaluation of the optic canal in sudden traumatic blindness.

Using computed tomographic scans and reformatted images of the optic canal region, we were able to define osseous abnormalities in nine patients with sudden traumatic blindness resulting from indirect trauma to the optic nerve. Six patients had optic canal fractures, two had fractures of adjacent structures, and one patient did not have a fracture. Patients received corticosteroid therapy, surgical decompression of the optic canal, both types of treatment, or no specific treatment for the nerve injury. Although there was no correlation between the abnormality identified by computed tomography and treatment results, our findings provided further evidence that a canal fracture is not necessary for injury of the optic nerve to occur. We recommend that patients with sudden visual loss after blunt head trauma undergo a computed tomographic scan of the optic canal region.

Adolescent↗
PubMed1984

CT demonstration of optic canal fractures.

Traumatic blindness is a well recognized entity with a guarded prognosis. Previous studies have variously reported the incidence of concomitant optic canal fractures and response to surgical therapy. With the advent of CT scanning, a new technique for study of these severely injured patients has become available. Over a period of 20 months, optic foramen fractures were demonstrated in 10 such patients using finely collimated, high-resolution CT scans. Fractures were easily classified by location, relation to the optic nerve assessed, and associated facial injuries imaged. The technique is easy, rapid, and superior to polytomography in this setting. Possible implications for therapy are discussed.

Adult↗
PubMed1982

Assessing the risk of retinitis pigmentosa with age-of-onset data.

Early characteristic electrophysiologic and ophthalmoscopic changes may help predict the development of retinitis pigmentosa. Until recently, if these were absent or equivocal, the ophthalmologist had to rely on the family pattern of transmission and simple Mendelian genetic methods to calculate the patient's risk of manifesting the disease. We used data on age of onset of subjective night blindness in 229 patients with retinitis pigmentosa (189 with autosomal recessive disease, 27 with autosomal dominant disease, and 13 with X-chromosome-linked disease) with Bayesian methods of probability calculation to predict the risk of retinitis pigmentosa development in a given patient more accurately than is possible with simple Mendelian methods. The risk for one subject used as an example was reduced from 50% to 12.9%.

Adolescent↗
PubMed1977

The clinical significance of retinitis pigmentosa without pigment: a computer assisted analysis.

Sixty-eight consecutive patients with retinitis pigmentosa were studied to determine the frequency of the non-pigmented form of the disease. There was an overall incidence of 22%. Fifty percent of all cases had no characteristic pigmentation, if the duration of night vision difficulty was three years or less. The study lends statistical support to the concept that the non-pigmented form of retinitis pigmentosa is frequently an early stage of the disease and not an unusual or atypical variant. Patient without the pigmentary changes characteristic of the disorder also showed less functional impairment: the ERG b-wave was more apt to be recordable, although impaired; and the rod threshold, as determined by dark adaptation measurement, was less elevated. The clinician should suspect retinitis pigmentosa, even in the absence of pigmentary changes, if there is a family history of the disorder, night blindness, peripheral field loss, and an impaired or non-recordable electroretinographic response.

Dark Adaptation↗
PubMed1976

Retinitis pigmentosa without pigment.

Sixty-eight consecutive patients with retinitis pigmentosa were studied to determine the frequency of the nonpigmented form of the disease. There was an overall incidence of 22%. Fifty percent of all cases had no characteristic pigmentation, if the duration of night vision difficulty was three years or less. The nonpigmented form of retinitis pigmentosa was frequently an early stage of the disease and not an unusual or atypical variant. Patients without the pigmentary changes characteristic of the disorder also showed less functional impairment: the electroretinographic b wave was more apt to be recordable, although impaired, and the rod threshold, as determined by dark adaptation measurement, was less elevated. The clinician should suspect retinitis pigmentosa, even in the absence of pigmentary changes, if there is a family history of the disorder, night blindness, peripheral field loss, and an impaired or nonrecordable electroretinographic response.

Electroretinography↗
PubMedDate not supplied

Use of botulinum toxin to treat blepharospasm in a 16-year-old with a dystonic syndrome.

A 16-year-old boy with generalized dystonia had continuous, severe blepharospasm and facial grimacing. Local intradermal injections of botulinum A toxin greatly reduced the spasms and improved function. No side effects were observed. Local botulinum A toxin injections may be useful in the treatment of eyelid and facial spasms in patients with generalized dystonias.

Adolescent↗
PubMedDate not supplied

Congenital absence of the lacrimal puncta.

We report seven cases of congenital absence of the lacrimal puncta, a condition that may be either an isolated finding or associated with other developmental anomalies. General pediatric evaluation of two patients with punctal agenesis revealed no additional abnormalities; these cases were managed by probing and silicone intubation. The other five cases were associated with other significant, clinically obvious abnormalities; several of these patients required more aggressive management of their lacrimal disorders, including dacryocystorhinostomy and conjunctivo-dacryocystorhinostomy. Previous reports support the impression generated by this series that otherwise normal appearing children with congenital absence of the lacrimal puncta do not require an extensive work-up. Probably many children with absent puncta are asymptomatic and remain undiagnosed.

Adolescent↗