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Biomedical subjects

S Poser

Publications and source records attributed to S Poser.

At least 145 records · Page 8Linked to original sources
PubMed1982

[Various forms in the course of multiple sclerosis].

In a multicentre study the data of 2057 patients with multiple sclerosis were recorded and analysed in respect to the different courses. The remitting form begins at earlier age with a higher frequency of sensitivity disturbances, optic neuritis and other cranial nerve disturbances whereas the chronic progressive process starts with spastic pareses and sphincter disturbances in a higher percentage of cases. During the further course these differences persist. With the beginning of a chronic progression the prognosis is unfavorable whether the process started with bouts or with progression from onset. 22% of the cases have a benign course (increase of not more than 1 degree of disability during a 5-year-period). In an epidemiological material the percentage of benign cases is at least one third. Except of the above statements the clinical symptomatology could not be correlated to the prognosis.

Adult↗
PubMed1981

Rehabilitation for patients with multiple sclerosis?

In the epidemiological area of Southern Lower Saxony 92 patients with clinically definite or probable diagnosis of multiple sclerosis (MS) were interviewed and examined. This group contained a remarkably high percentage of benign cases (52%) in comparison with a sample of hospitalized patients. Neurological examination revealed spasticity and pareses to be the most important disturbances followed by ataxia and bladder/bowel problems. After a mean duration of 18.4 years, 52% received a pension and about 30% were still working full time. The pension was granted too early to 11 patients and vocational rehabilitation services would be required for 13 men. Although only half of the patients had an acceptable income, the socioeconomic situation of the families was adequate in 71%; 80% lived with their own families and could stay there in case more ambulant services were offered. Psychotherapeutic measures are required among these to relieve the stress within the families (present in 42%)and to improve the coping behavior (unsatisfactory in 60%).

Disability Evaluation↗
PubMed1981

HLA-antigens and the prognosis of multiple sclerosis.

The histocompatibility pattern of 160 patients with multiple sclerosis (MS) living in the epidemiological area of Southern Lower Saxony was determined and compared to a control population. The only significant difference was the more frequent occurrence of DW2 in the patient group (44% vs. 21%). Taking a progression index (grade of disability divided by the duration of the disease) as a measure for prognosis no difference could be found between the DW2 positive and the DW2 negative patients. The reason why we could not confirm the worse prognosis for DW2 positive patients found by Jersild et al. (1973) and Raun et al. (1980) remains to be investigated.

Ethnicity↗
PubMed1981

[Endocrinological findings in patients with multiple sclerosis (author's transl)].

In 15 patients with multiple sclerosis about half of the patients showed decreased gonadotropin and estrogen values in the urine. A control examination of these findings in 19 additional patients showed normal plasma FSH and LH values. Except for one slightly elevated value the prolactin levels were normal in this group.

17-Ketosteroids↗
PubMed1980

[Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (author's transl)].

The position of benzodiazepine dependence among addiction diseases was studied retrospectively by analysing the case reports of in-patients at the Psychiatric Clinic, Göttingen. Addicts constitute the largest group of patients in this clinic, a situation probably true in general of psychiatric hospitals in the Federal Republic of Germany. Isolated alcoholism is the most frequent addiction, followed by combined alcohol-drug dependence and pure drug dependence. At present, benzodiazepines are the most commonly used addictive drugs. Although most of benzodiazepine dependents have changed to it from another drug, primary benzodiazepine dependence is increasing. Among the benzodiazepines, lorazepam seems to have a particularly high addiction potential. On withdrawal of benzodiazepines, symptoms were less marked than after stopping a combination of benzodiazepines and alcohol, and (or) barbiturates; they generally developed with some time delay.

Alcoholism↗
PubMed1980

Optic neuritis as an initial symptom in multiple sclerosis.

The present study is based on a multicenter documentation system which includes standardized information on a total of 1271 patients with multiple sclerosis (MS). In 441 (34.7%) cases the optic nerve was involved at the first appearance of the disease, and in 212 (16.6%) subjects optic neuritis (ON) was the sole initial sign. For all MS patients with ON at the onset of the disease the female to male ratio was 1.3, whereas it was 1.5 for the whole series. The mean age at onset was 2 years lower for patients with initial ON as compared with the whole series (29.0 and 31.1 years, respectively). Correlation of the disability of the patients to the duration of the disease revealed the best prognosis for patients with ON as the sole inital sign of MS. The frequency of brainstem/cerebellar and pyramidal signs was lowest among these patients at the time of the present examination. The difference was more pronounced during the first years of the disease and disappeared after longer duration. The correlation curves of disability to the present age of the patients confirmed this pattern. Our findings do not support the idea of initial ON as being a favorable sign of the later course. As an initial bout of MS, it reflect more precisely the mean age of onset of the disease than other signs.

Adult↗
PubMed1979

Clinical data and the identification of special forms of multiple sclerosis in 1271 cases studied with a standardized documentation system.

In a multicenter study the clinical data of 1271 patients with multiple sclerosis (MS) were recorded in a standardized manner and analysed by a computer program. Some of the retrospective data are compared with previous reports. The frequency of optic nerve involvement in the present series was close to the Japanese figures. The development of signs and symptoms during the course of MS was given for the 1271 patients and differences in the reversibility of symptoms are presented. In this study, one of the chief purposes was the selection of groups of MS patients with particular symptomatology and course of the disease for prospective, detailed study. The following groups were selected and are under further investigation: 109 patients with an exclusively spinal symptomatology throughout the course of their disease; 441 patients with optic neuritis as initial symptom; 110 patients with early brain-stem involvement; 64 benign cases (duration of the disease more than 14 years and disability not more than 3 according to Kurtzke), 35 malignant cases (duration of the disease under 5 years and disability grade of 7 or more); 83 families with more than one member with MS; 289 females with a history of pregnancy, childbirth and/or use of oral contraceptives. In 339 patients a lumbar puncture was performed at the present examination. The parameters determined constitute a pathognomonic pattern highly indicative of the diagnosis of MS.

Brain Stem↗
PubMed1978

Clinical features of the spinal form of multiple sclerosis.

Out of a data pool of 1271 patients with Multiple Sclerosis (MS) a total of 109 cases are selected having a sole spinal symptomatology throughout the course of the disease. This group differs in three particular features from the non-spinal forms of MS: In this group there is a higher percentage of females, the age at onset of the disease is higher, and the course of the disease is more often chronic progressive from the beginning. After the mean duration of 11 years, the spinal and the non-spinal cases show the same grade of disability. The ability to work is slightly better for spinal cases; office workers are able to keep their jobs longer after the onset to the disease than patients with any other occupation. The spinal form of MS is discussed in respect to its relationship to the classical form of MS and as a differential diagnosis to other spinal processes.

Adult↗
PubMed1978

[The social and medical situation of people suffering from multiple sclerosis--considerations on the basis of an epidemiologic field study (author's transl)].

Within the framework of an epidemiologic field study conducted in South Niedersachsen a standardised questionnaire was used to obtain data on the social and medical situation of persons with multiple sclerosis. Of the 195 people with multiple sclerosis questioned in that area in 1976 answers were received from 178 (91%). The mean age was 46 years, the average history of disease 15 years. Family status and social position corresponded to social average. A social downfall as a result of the disease was not found to have taken place. Approximately 50% who had been employed prior to the disease (N = 147) had given up their jobs at the time of the survey. The monthly net income was found to be average. Of the studied persons 42% were living in their own houses or flats. A lower percentage, compared to the general public, was living in lodgings (58% instead of 65,7%). The majority (56%) was living in flats suitable for the disabled. 13% of the surveyed persons lived alone, 5% in homes. Social care was found to be very poor in comparison with medical treatment. The introduction of compulsory notification for this disease was advocated by 83% of the people questioned.

Adolescent↗