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Biomedical subjects

S Porat

Publications and source records attributed to S Porat.

At least 55 records · Page 3Linked to original sources
PubMed1987

Decreased adhesion formation in flexor tendons by topical application of enriched collagen solution--a histological study.

In order to improve gliding function of damaged flexor tendons in chickens, we topically applied enriched collagen solution (ECS) to the tendon sheaths of severed tendons. Previous studies using the same experimental model showed improvement of gliding function in the damaged tendons biomechanically and increased collagenolytic activity in the area of the damage after application of ECS. In the present study we evaluated the influence of ECS on peritendinous adhesion formation and on the healing process of the tendons histologically. We found that topically applied ECS reduced adhesion formation, mostly during the first week, without adversely affecting tendon healing or scar maturation.

Administration, Topical↗
PubMed1987

Osteolytic osteogenic sarcoma of ilium in 46-month-old boy.

A 46-month-old boy with a four-day history of pain and swelling over the right posterior ilium was thought to have acute osteomyelitis on the basis of a normal pelvic x-ray, markedly increased scintigraphic activity in the right ilium, and a mildly elevated sedimentation rate. At surgery, no signs of osteomyelitis were found, and biopsy revealed osteolytic osteogenic sarcoma. This is the youngest child with osteogenic sarcoma of the pelvic reported in the literature.

Bone Neoplasms↗
PubMed1986

The effects of cold upon bone growth: a preliminary study.

The effects of various degrees of cold injury upon bone growth were experimentally studied. Young rabbits' feet, rendered ischemic by the application of a tourniquet, were cooled down by immersion in either an ice bath at 0 degrees C or an alcohol bath at -20 degrees C. The bone injuries were assessed clinically, radiologically, and histologically. Prolonged exposures to low temperatures above freezing do not cause any bone damage. Brief exposures to temperatures between -20 degrees C and -15 degrees C affect bone growth by inducing premature arrest of the epiphyseal plate, destruction of the epiphysis, and reactive-endosteal and periosteal bone formation. These effects lead to a statistically significant shortening and widening of the affected bones, which can be demonstrated radiologically. Low temperatures have a primary direct lethal effect upon the highly sensitive chondrocytes of the epiphyseal growth plate. Bone damage is independent of associated soft-tissue injuries and not linked to frostbite of the extremity or to solidification of tissues.

Animals↗
PubMed1986

Femoral fracture treatment in head-injured children: use of external fixation.

Seven cases of femoral fractures in head-injured children with spasticity and/or decerebrate posturing and seizures were treated with external fixation. The fractures healed with good alignment, maintenance of length, and without infection. The technique is recommended both for its simplicity and lack of complications relative to other management approaches.

Child↗
PubMed1986

Differential leukocyte count in infants of diabetic mothers. Increased band count associated with macrosomia.

The differential leukocyte count was studied within the first 24 hours of life in 115 infants of diabetic mothers (IDMs) appropriate for gestational age (AGA), 16 IDMs large for gestational age (LGA), 104 infants of non-diabetic mothers (INM's) AGA, and 22 INMs-LGA. A significant "shift to the left" was found in IDM's-LGA only. The usual cause of "shift to the left" such as maternal hypertension or fever, respiratory distress syndrome, meconium aspiration, neonatal asphyxia, sepsis, convulsions, or hypoglycemia could not explain this finding. It is hypothesized that increased glucocorticoid secretion may possibly play a role.

Adult↗
PubMed1985

Increased collagenolytic activity in severed and sutured tendons following topical application of exogenous collagen in chickens.

To verify the role of collagenase in reduction of peritendinous adhesion by topical application of exogenous collagen, the flexor tendons of 30 chickens were severed and sutured. Exogenous, native enriched collagen solution (ECS) was introduced in the tendon sheath via a polyethylene catheter. The effect of ECS on collagenolytic activity in the healing tendon was assessed 1, 2, and 3 weeks later both by determining the relative amounts of dialyzable protein and hydroxyproline and by using the collagen film collagenase assay. The results obtained indicated a significant increase in both dialyzable hydroxyproline level and collagenolytic activity in the ECS-treated tendons as compared with the untreated controls. It is suggested that the effect of the topically applied exogenous collagen on increasing the collagenolytic activity may be directly related to previously observed increased gliding capacity of the tendons in the same experimental model.

Animals↗
PubMed1984

Erythrocyte (Ca2+ + Mg2+)-ATPase activity and calcium homeostasis in Duchenne muscular dystrophy.

Because the erythrocyte (RBC) in Duchenne's muscular dystrophy (DMD) is thought to be a suitable experimental paradigm for the sarcolemma, the RBC membrane-bound enzyme (Ca2+ + Mg2+)-ATPase has been investigated as to its relevance to abnormalities of calcium metabolism in DMD muscle. In this study, RBC (Ca2+ + Mg2+)-ATPase activity, intracellular calcium and potassium contents and complete hemogram were examined in 10 DMD patients and 16 age-matched controls. (Ca2+ + Mg2+)-ATPase activity was found elevated in the DMD RBC, consistent with reports from previous studies, but no abnormalities in intracellular calcium, potassium or hemograms were detected. It seems that although the (Ca2+ + Mg2+)-ATPase activity is changed, it bears no relevance to calcium homeostasis in DMD RBC. It is inferred that the increase in intramuscular calcium in DMD muscle, which is also found in other neuromuscular diseases, may be a non-specific finding in the diseased muscle and part of the final common pathway leading toward cellular degeneration and death.

Adolescent↗
PubMed1984

Hydatid disease of the spine causing paraplegia. The combined treatment by surgical drainage and mebendazole: a case report.

Hydatid disease of the spine is a rare disease with a poor prognosis. Paraplegia is a severe complication and has a low chance for recovery. Surgical drainage and decompression has been the treatment of choice although success was limited. Medical treatment with mebendazole was introduced in 1977 for cystic and alveolar Hydatid disease of the liver. In this paper, a case with Hydatid disease with complete paraplegia is presented. He was treated by combined surgical and medical treatment that included several surgical drainages, decompression, and fusion procedures, accompanied by high dose mebendazole for three years. Recovery from the paraplegia was complete except for the persistence of a neurogenic bladder. Neither clinical nor laboratory evidence of activity of the disease existed after six years of follow-up. This case must encourage further clinical trials in such cases, combining surgical treatment with mebendazole.

Benzimidazoles↗
PubMed1984

The history of treatment of congenital clubfoot at the Royal Liverpool Children's Hospital: improvement of results by early extensive posteromedial release.

The results of treatment in 77 clubfeet were assessed after an average follow-up of 8 years. In those patients with surgical treatment it was found that the Turco posteromedial release within the first 3 months of life resulted in 13 of 16 satisfactory feet. In comparison, only five of 21 feet had satisfactory results when the average age of operation was delayed to 3.7 years and a less extensive release performed. At follow-up, abnormal radiological findings were not found in the early operated cases. The average talocalcaneal index was 47 degrees. The late operated feet showed major abnormal X-ray film findings, and their average index was 38 degrees. Good functional results, however, often coexisted with abnormal radiological findings in the midfoot. Abnormal findings of the hindfoot were always associated with unsatisfactory results. We conclude that the use of early (3 months) Turco posteromedial release can offer excellent results in treating severe resistant clubfeet.

Adolescent↗
PubMed1984

Disseminated mycobacterial disease caused by Mycobacterium szulgai.

Disseminated mycobacterial disease due to Mycobacterium szulgai occurred in a previously healthy young man. The clinical picture included fever, mediastinal and generalized lymphadenopathy, hemoptysis, and skin lesions but was dominated by progressive multifocal osteomyelitis. Immunological studies revealed a decrease in T-lymphocyte reaction to mitogens, but this was tested late in the course of the disease and may have been secondary. In spite of repeated surgical drainage and treatment with multiple antituberculous drugs for a period of two years, new lesions continue to appear mainly in the bones. Mycobacterium szulgai was isolated from 28 bone specimens, as well as from skin lesions and sputum. To the best of our knowledge, this is the first report of disseminated disease due to this organism.

Adolescent↗
PubMed1981

Radial trans-scaphoid perilunate dislocation.

An unusual case of trans-scaphoid perilunate fracture-dislocation of the carpus with radial displacement in a 19-year-old man is reported. On the basis of the clinical and radiologic findings it was assumed that the tip of the radial styloid process caused the scaphoid fracture. Following closed reduction with acceptable positioning of the carpal bones, the patient has good function and slight pain, and was able to return to almost full employment about 1 year postinjury.

Adult↗
PubMed1980

Improvement of gliding function of flexor tendons by topically applied enriched collagen solution.

The long flexor tendons of the second, third and fourth toes of 94 chickens were cut and sutured. After operation the birds were divided into three groups. To reduce peritendinous adhesions, an aqueous solution of beta-aminopropionitrile (BAPN) was added to a solution of enriched native collagen (ECS) and applied to the cut tendons of one group; untreated controls and controls treated with collagen solution alone comprised the other groups. Chickens from each group were killed one, two, three, four and five weeks after operation. The results were evaluated both biomechanically and biochemically. It was found that the collagen solution alone had the same effect as the treatment with BAPN. It is suggested that the exogenous collagen present at the site of injury binds the collagenase inhibitor released by tendon cells, thus providing enough active collagenase to control the formation of fibrous adhesions. The inefficiency of BAPN in these experiments might have been due to either inadequate dosage or wrong timing, or both.

Aminopropionitrile↗
PubMed1978

Hydatid disease of bone: a case report and review of the literature.

A rare case of hydatid disease involving the iliac bone is reported. The non-specific presenting history, the intraoperative diagnosis, the multiple recurrences and the relentless local spread of the disease are characteristically demonstrated in this patient over a 14-year follow-up period. An unusual form of radical surgery, resection of the ilium, did not succeed in eradicating the disease.

Bone Diseases↗
PubMed1978

Solitary bone cyst in the infant radius. A case report.

The exceptional case in the distal radius of an 18-month-old girl demonstrates the natural history and characteristic features of solitary bone cyst at an early age. There were recurrent pathological fractures and even recurrence of the cyst, but spontaneous complete healing occurred after a period of 7 years. Splinting of the fractures, curettage and bone graft were performed per primum. Aspiration of the cyst and collapse of the cyst walls were secondary procedures. The recommended treatment is biopsy and prolonged immobilization until spontaneous healing of the cyst is complete.

Bone Cysts↗