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Biomedical subjects

S Peterson

Publications and source records attributed to S Peterson.

125 records · Page 7Linked to original sources
PubMedDate not supplied

Comparison of the behavior of the curly tail and CBA mouse on a neurologic scale.

ct/ct mice are a mutation of the CBA strain with a high incidence of spina bifida (SB). Because humans with SB can exhibit abnormal behavior, we compared ct/ct and CBA mice using a neurologic assessment tool. ct/ct mice are more active and engage in more climbing, and stereotypical and compulsive behavior. When stimulated during cage removal ct/ct mice react more vigorously. ct/ct mice react more vigorously to a novel stimulus, and will vigorously search for a stable surface during visual placement. In the open field ct/ct mice crossed more lines and reared more than CBA. ct/ct mice demonstrated deficient performance in a modified Morris water maze. No differences were noted for other behaviors tested. The results argue that the mutation that produces SB in ct/ct mice also alters brain structure or chemistry. This is consistent with the findings in humans where SB can produce a variety of behavioral anomalies, most notably hyperactivity, attentional disorders, learning disabilities, and developmental lags.

Animals↗
PubMedDate not supplied

Options for recovery: promoting success among women mandated to treatment.

In recent years imprisonment has been used increasingly for a wide range of nonviolent and petty offenses committed by women. Among incarcerated women, particularly those who are pregnant or parenting, substance use and its deleterious consequences are often exacerbated by imprisonment. Women who have been identified as chemically dependent are also at high risk for losing custody of their children. In California, the Options for Recovery (OFR) treatment program provided an alternative to incarceration or relinquishment of custody of children for chemically dependent pregnant and parenting women. This three-year pilot project offered alcohol and other drug abuse treatment and case management to these women, and included special training and recruitment of foster parents for their children. Findings from a three-year, multimethod evaluation study showed that women who were mandated to OFR treatment programs were more likely to successfully complete treatment than women who had enrolled in OFR voluntarily. An economic analysis of the costs associated with women in OFR compared with the combined costs of incarceration and alcohol and other drug abuse treatment produced a ratio in favor of OFR. Additionally, some innovative service alternatives for women mandated to treatment were developed during the project. The impact of such changes have implications for improving women's and family health.

Adult↗
PubMedDate not supplied

Functional significance of PMM2 mutations in mildly affected patients with congenital disorders of glycosylation Ia.

PURPOSE: Congenital disorders of glycosylation (CDG) result from mutations in N-glycan biosynthesis. Mutations in phosphomannomutase (PMM2) cause CDG-Ia. Here, we report four clinically mild patients and their mutations in PMM2. METHODS: Analysis of the PMM2 cDNA and gene revealed the mutations affecting the glycosylation efficiency. RESULTS: The patients have 30% to 50% normal PMM activity in fibroblasts due to different mutations in PMM2, and we studied the effect of each mutation on the PMM activity in a Saccharomyces cerevisiae expression system. CONCLUSIONS: Each patient carried a severe mutation that decreased the PMM activity to less than 10% as well as a relatively mild mutation. A new mutation, deletion of base 24, changed the reading frame. The C9Y, C241S, and L32R mutations showed 27% to 45% activity when expressed in the eukaryotic expression system, and the more severe D148N was shown to be thermolabile.

Alleles↗
PubMedDate not supplied

Comparative genomics and understanding of microbial biology.

The sequences of close to 30 microbial genomes have been completed during the past 5 years, and the sequences of more than 100 genomes should be completed in the next 2 to 4 years. Soon, completed microbial genome sequences will represent a collection of >200,000 predicted coding sequences. While analysis of a single genome provides tremendous biological insights on any given organism, comparative analysis of multiple genomes provides substantially more information on the physiology and evolution of microbial species and expands our ability to better assign putative function to predicted coding sequences.

Bacteria↗
PubMedDate not supplied

The management of cor pulmonale.

Pulmonary artery hypertension occurs when there is a sustained elevation of the mean pulmonary pressure above normal physiologic values. This may then lead to cor pulmonale or enlargement of the right ventricle due to any lung disease in the absence of left heart failure. When the ability of the right ventricle to compensate is overwhelmed, right-sided heart failure can occur. Pulmonary artery hypertension may be idiopathic (primary) or secondary to a variety of lung parenchymal diseases, airways disease, pulmonary circulatory disorders, systemic illnesses, or thoracic mechanical abnormalities. Treatment strategies for cor pulmonale include supplemental oxygen, assisted mechanical ventilation, digoxin, and diuretics. Pulmonary vasodilator compounds should be used with caution because they can compromise gas exchange in cor pulmonale from secondary pulmonary hypertension. Trials with digoxin and inotropic agents have been evaluated. Angiotensin-converting enzyme inhibitors have not shown significant utility, at least acutely. Anticoagulation may decrease mortality in some patients with pulmonary artery hypertension and cor pulmonale.

Cardiovascular Agents↗