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Biomedical subjects

S Pawelski

Publications and source records attributed to S Pawelski.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

[Analysis of 300 cases of secondary pancytopenia].

Clinical analysis of 300 cases of secondary pancytopenia treated in a period of 10 years is reported. The disease was more frequent in women than in men. The most frequent single cause were drugs, among them chloramphenicol. Most patients had pancytopenia and hypoplastic bone marrow. The mortality was 37%. Death occurred most frequently in the first 6 months of the disease due to infection or thrombocytopenic heamorrhagic diathesis. The results of treatment with corticosteroids and androgenic steroids were unsatisfactory.

Adolescent↗
PubMedDate not supplied

[Effect of mitogens on the changes in intracellular cyclic AMP concentration in the lymphocytes of healthy persons and patients with lymphoblastic leukemia].

In the lymphocytes of 20 healthy subjects and 17 patients with chronic lymphatic leukaemia (CLL) the cAMP level was determined before and at different time periods during cell incubation with mitogens (phytohaemagglutinin--PHA, concanavalin A--Con A, and pokeweed mitogen PWM). The experiments demonstrated that PHA-induced lymphocyte proliferation was associated in healthy subjects during the first 10--20 minutes of incubation with a rise in the intracellular cAMP concentration, while the level of cAMP decreased systematically during 30 minutes of incubation with Con A and PWM. Incubation of lymphocytes of the patients with CLL during 30 minutes with PHA, Con A and PWM caused no changes in the low cAMP level in these cells. The obtained results suggest that PHA activation of lymphocytes in healthy subjects is connected with changes in the intracellular concentration of cAMP.

Adult↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. I. Results of intensive chemotherapy of 106 patients with acute leukemia].

In a period of 5 years 106 patients with acute leukemia were treated (93 with acute nonlymphoblastic leukemia and 13 with acute lymphoblastic leukaemia. Four therapeutic programmes were used. Complete remission (CR) was achieved in 41% of patients, including 37% of those with acute non-lymphoblastic leukaemia and 77% with acute lymphoblastic leukaemia. The per cent of remissions obtained using different programmes was similar. During intensive induction treatment 22% of patients died, mainly of infections and bleeding tendency.

Acute Disease↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. III. Analysis of 5 cases with survival over 21/2 years].

Out of 49 adult patients with acute leukaemia admitted successively over a period of 3 years (1976-1978) those surviving next 1.5 year were followed up (till June 30 1980). Forty-one cases were qualified for combined treatment with cytostatic drugs. Five patients are alive over 2.5 years (30-46 months), three of them in the first complete remission (28-33 months), one patient in second remission, and one patient is alive with relapse after first complete remission. The per cent of patients surviving over 2.5 years is 10.2% of the successively admitted patients, and 12.2% of those treated with cytostatic drugs. This fairly long survival may be due to intensive induction treatment and maintenance treatment.

Acute Disease↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. V. The effect of intrathecal cytostatic therapy on leukemic changes in the central nervous system].

In a period of 5.5 years from 1975 to 1980 the neurological status of 82 patients with various forms of acute leukaemia was assessed at the Institute of Haematology and in 42 cases central nervous system involvement was found. These patients were treated by intrathecal administration of drugs according to three programmes. Remission after intrathecal treatment was achieved in 31 cases. No improvement of the neurological status was obtained in 31 cases. No improvement of the neurological status was obtained in 4 cases. Forty-eight patients without neurological signs received prophylactically intrathecal treatment which failed to prevent central nervous system leukaemia in 8 cases.

Acute Disease↗