[Transcutaneous heparin therapy in thrombotic cardio-vascular pathology. Apropos of 44 emergency cases].
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Biomedical subjects
Publications and source records attributed to S Pattin.
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Following-up a survey made in 1969 on 100 ex-soldiers suffering from the Fiessinger-Leroy-Reiter syndrome in Algeria, a new study investigated the evolution in 85 subjects, 85 percent of whom had suffered from the syndrome for 10 years or more. Those considered cured represented in the new study nor more than about 50 percent, instead of 65 percent, recurrences remained unchanged (15 cases out of 85 instead of 18 out of 100), the proportions with ankylosing spondylarthritis of the sacroiliac joints changed from 14 to 26 percent, and 5 patients remained unclassifiable. Sacro-iliac ankylosing spondylarthritis appeared in approximately half the cases in the 5 years that followed the commencement of the syndrome. Contrary to the findings in 1969, two cases of sacro-iliac ankylosing spondylarthritis were noted in patients who had experienced relapses. At present those in the cured group are those in whom the syndrome commenced the most recently and further deterioration in the figures may be expected in the years to come. Thus the long-term prognosis is difficult to evaluate from the initial symptoms. The severity of the evolution is only moderate, however, and without doubt the differences between individuals play an important role. The authors remain convinced of the principal that persons suffering from FLR are less likely to develop.
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The joint manifestations of parasitic diseases are rare. They may be due to the presence of a parasite within one or severed joints, to involvement of a neighbouring joint, or distant involvement due to an immuno-allergic mechanism. The latter category constitutes what one may call parasitic rheumatism. The latter is characterised by arthropathies of inflammatory type with raised sedimentation rate, marked but inconstant hypereosinophilia, and total inefficacy of antirheumatic treatments. The diagnosis of parasitic rheumatism depends on these criteria, on the diagnosis of the parasitic disease in question, above all filariasis but also other parasitic diseases, and above all the great efficacy of specific anti-parasitic treatments.
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The authors report 2 cases of probable algodystrophy of the lower extremities, associated to a definite deep venous thrombosis. They discuss the relationships between the two diseases and the difficulties of the differential diagnosis in light of a third case where the algodystrophy is definite and manifests itself as a deep venous thrombosis confirmed by phlebography. They insist on the absolute need to rule out a deep venous thrombosis before considering the exceptional diagnosis of algodystrophy with pseudo-phlebitic manifestations.
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Fatigue fractures of the foot are the commonest fatigue fractures, still called walking fractures or "stress fractures". Formerly, they were metatarsal in more than 80% of cases: over the last few years, the calcaneal localizations mainly predominate (more than 70%). The fatigue fractures formerly described almost always in soldiers after a long march, are in fact encountered at all ages, including children, and in both sexes. The diagnosis in usually easy, provided that one thinks of it. It depends on the history, on clinical examination with pain on palpation of the bone, on a bone scan which shows early hyperfixation, on radiological examination, in which signs appear later than on clinical examination, and the bone scan, thus X rays often have to be repeated. The treatment is simple. Relief of weight bearing is usually sufficient. Plaster is usually neither necessary nor useful. Prophylaxis consists of avoiding physical activity, especially prolonged walking without prior gradual training.
Anti-inflammatory treatment of ankylosing spondylitis is based on the administration of the various non-steroid anti-inflammatory agents made available since the introduction of phenylbutazone. As with this later compound they each have a group of patients that respond to their administration and are able to tolerate them. In this way, physical education exercises can be undertaken for the spine and chest several times a day, which is the only therapy capable of improving prognosis and avoiding stiffening and spinal deformities. A study protocol is proposed that has the advantage of allowing a rapid evaluation of the efficacy and tolerance of the products successively administered for short periods, by using scored evaluation criteria. The most effective and better tolerated compound for each patient can thus be determined. This protocol is valid for both general practice or therapeutic study use, and in open or double-blind trials.
A patient with sympathetic reflex dystrophy following injury to the right foot presented fairly typical clinical and radiological signs, though the hot phase was particularly short. Bone scan with technetium 99 m pyrophosphates demonstrated hypofixation, which, though extremely rare, has been previously reported in the published literature. The fact that isotopic bone hypofixation can occur during sympathetic reflex dystrophy should be recognised, as far from constituting an argument against the early diagnosis of this affection, it should enable the organic nature of the disorder to be confirmed, and assist the physician in making an early diagnosis.