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Biomedical subjects

S Pattin

Publications and source records attributed to S Pattin.

At least 91 records · Page 5Linked to original sources
PubMed1976

[Dysenteric rheumatism. What remains in 1976?].

Joint manifestations that occur during or after an episode of dysentery, grouped under the name of dysenteric rheumatism, have been known since antiquity, and have been mainly found in military circles, in camps, or during military campaigns. After reviewing the principal epidemics of rheumatism complicated by joint manifestations, the authors show that the only different feature about what is called dysenteric rheumatism is the particular character of the joint manifestations which may be isolated or associated with other manifestations, notably ocular or urethral, forming then what is called the Fiessinger-Leroy-Reiter syndrome. The role of the dysentery bacillus in the genesis of the joint lesions is not clear. Although it may been suspected on the basis of epidemiological or bacteriological arguments in some cases, it has never been formally demonstrated and is often non-existent. The term dysenteric rheumatism is too restrictive and should henceforth be abandoned.

Adult↗
PubMed1976

[The lymphocyte transformation test with the bedsonian antigen (bedsonian LTT) in old and recent Fiessinger-Leroy-Reiter syndromes and in ankylsoing spondylarthritis. Additional study].

The lymphoblastic transformation test in the presence of bedsonian antigen was positive in 72 per cent of the cases confirmed Fiessinger-Leroy-Reiter syndrome, while it was negative in all the controls. This test remains positive over a long period since it was found to be positive in 69.75 per cent of old cases of FLR syndrome diagnosed 13-17 years previously. In cases of post-Reiter ankylosing spondylarthritis (ASp), the bedonian LTT was positive with equal frequency as in cases of FLR syndrome not complicated by ASp (68.4 per cent). On the other hand, in the cases of ASp without known history of FLR the test was positive much less frequently (17.7 per cent). There was no significant difference between the positivity rate of the bedsosian LTT in cases of pure axial ASp and in cases of ASP with peripheral lesions, neither in the group with post-Reiter ASp nor in the group with idiopathic ASp. In addition to its diagnostic value, this test is of great value in the epidemiological study of the group of rheumatic diseases that includes the FLR syndrome and ASp.

Antigens, Bacterial↗
PubMed1975

Clinical study of a new anti-inflammatory and analgesic compound, benorylate, in rheumatic disorders.

Benorylate is obtained by esterification of acetylsalicylic acid and N-acetyl p-aminophenol (4-acetamidophenyl 2-acetoxybenzoate). Experimentally, this new product has been shown to be a good analgesic and anti-inflammatory agent. A clinical trial was carried out in order to study the efficacy, side effects and tolerance of this new product. In a group of 49 hospitalised patients aged from 20 to 70 years who were treated with this new product, 15 had ankylosing spondylitis, 11 had chronic progressive rheumatoid arthritis, 4 had Reiter's syndrome, 4 had psoriatic arthropathy, 8 had osteoarthrosis of the hip and 7 had various forms of rheumatism. The drug was administered orally in suspension form, initially three times per day, then twice, the total daily doses being 15 ml (6 g) or 20 ml (8 g). Treatment was regarded as effective in 62% of the cases, and of these 62%, 46% good and very good results were obtained. In 88% of the patients, tolerance was satisfactory and of these, it was excellent in 80%. Only in 2 cases did treatment have to be discontinued on account of side effects. From the biological point of view, uricaemia was significantly reduced in 7 patients, and in 6 patients uricuria increased. With regard to the level of salicylate in the blood assays showed that it is the same for 6 g benorylate and for 4 g aspirin. Benorylate has been shown to be an effective treatment for both inflammatory and degenerative rheumatic disorders. The results of its use can be compared with those obtained by acetylsalicylic acid, but is better tolerated. In addition, in chronic disorders it is better to have to take the product only twice per day.

Administration, Oral↗
PubMed1975

[Diffuse articular chondrocalcinosis and Paget's disease].

At the time of a personal observation of Paget's disease associated with a diffuse articular chondrocalcinosis (ACC) in a 75-year-old man suffering from diabetes and hyperuricaemia, the authors re-examined 61 patients suffering from Paget's disease to look for this association which had been previously mentioned by Radi et al. with the unusual frequency of 42 percent of cases. In 52 percent of their patients, who had undergone complete radiological examination of the skeleton, the authors found only one case of ACC, or 1.9 percent. Taking into account the respective frequencies of Paget's disease and of diffuse ACC in the general population aged more than 40 years, the results of this careful study led the authors to conclude that an association of ACC and Paget's disease is due to chance.

Adult↗