Search PubMed⌕ Search

Biomedical subjects

S Okamura

Publications and source records attributed to S Okamura.

At least 271 records · Page 15Linked to original sources
PubMed1985

[A study of bone metastasis of cervical carcinoma by bone scintigraphy].

In carrying out bone scintigraphy in 224 cases over the 5 years from June, 1978 to May, 1983 as a part of the post-treatment management of cervical carcinoma, we obtained the following findings concerning bone metastasis. Bone metastases were seen in 12.5% (28 cases) of the subjects, about 6% of the total post-treatment cases of cervical carcinoma in the corresponding period (466 cases). Bone metastases were seen in 9.3% (16/172) of post-operative cases, compared with 23.1% (12/52) of non-operative cases. Bone metastases were not seen in clinical stages Ia through IIa (49 cases) but were seen in IIb or higher stages. Bone metastasis rates by histological type, according to WHO classification, were 12.8% (26/203) in squamous cell carcinoma, 5.9% (1/17) in adenocarcinoma, and 25% (1/4) in adenosquamous carcinoma. Among the squamous cell carcinoma cases, small cell non-keratinizing type had the highest bone metastasis rate (p less than 0.05). Of 172 post-operative cases, 20.8% (11/53) of those with lymph node metastasis exhibited bone metastasis, higher than the 4.2% (5/119) in cases without lymph node metastasis. As to CPL classification, bone metastasis was seen more often in L type (18.8%) than C(0.0%) or P types (6.6%). Our risk classification of 168 cases demonstrated that bone metastasis was not seen in risk I group (74 cases), but was seen in 6.7% (1/17) of risk II group and in 19.0% (15/79) of risk III group. Twenty-eight cases with bone metastasis included 11 cases with local recurrence, 8 with pulmonary metastases, 4 with hepatic metastases and 4 with Virchow's lymph node metastases.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMed1984

A case of adult T-cell leukemia initiated with central nervous system symptoms.

We treated a 52-year-old Japanese woman with adult T-cell leukemia (ATL) initiated with central nervous system (CNS) symptoms. Her chief complaints were paraplegia and left facial palsy. CNS-ATL was diagnosed because of the following three features. 1) Various sized lymphoid cells with marked nuclear convolution were numerous in her cerebrospinal fluid. 2) These cells were a monoclonal proliferation of T lymphocytes with OKT 4 marker. 3) The patient's serum was positive for anti-ATL associated antigen (ATLA). Although the neurological signs and symptoms improved markedly after intrathecal administration of combined chemotherapy (methotrexate, cytarabine and corticosteroid), these ATL cells were highly resistant to radiation therapy. The abdominal mass which developed in the course of the disease was diagnosed as a tumor formed of ATL cells, and VEPA (vincristine, endoxan, prednisolone and adriamycin) was administered with marked success.

Antigens, Neoplasm↗
PubMed1984

[A statistical study of management based on prognostic factors after surgical treatment for cervical carcinoma].

In order to improve the therapeutic results after surgical treatment for cervical carcinoma, 236 patients treated from 1969 to 1976, who could be followed up for five years, were analyzed retrospectively. Various prognostic factors were studied by principal component analysis (quantification method III), and criteria of risk of recurrence were established. Using the discriminant function obtained, another series of 246 patients treated surgically experienced from 1977 to 1982, whose clinical stages were Ib or more, were divided into three groups according to the risk of recurrence and were managed accordingly. The patients in groups II and III, in whom recurrence was possible, received continuous adjuvant chemotherapy with Tegafur (400-600mg/day). The results obtained were as follows. In the principal component analysis, coefficients for the clinical stage, invasion into the parametrium, location of carcinoma and invasion into the uterine body were high on the X1-axis, considered to represent the tumor volume. On the X2-axis, considered to represent the tumor biological characteristics, coefficients of the histological type, CPL classification and lymph node metastasis were high. The risk of recurrence was calculated by the following discriminant function; Z = 0.810X1 + 0.710X2. The values obtained were Z less than 0.053 in group I, 0.053 less than or equal to Z less than 0.376 in group II and Z greater than or equal to 0.376 in group III. Using the equation, 246 cases from 1972 to 1982 were prospectively divided into three groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMed1983

[Diagnosis of ovarian tumors by CT and 67Ga-citrate scintigraphy].

Computed tomography (CT) and 67Ga-citrate computer scintigraphy (67Ga-CS) were carried out on 184 patients with ovarian tumors. CT(EMI scanner model 5005/12 or General Electric model CT/TX-2) was performed in 169 cases and 67Ga-GS in 128, after visualization and calculation by computer. In 113 cases diagnosis was made with the combined use of both methods and CT number and ROI counts in 67Ga-CS were obtained. Dermoid cysts were easily detected by their characteristic CT image and CT number. The mechanism by which 67Ga accumulated in malignant tumors was investigated and 67Ga was found mainly in microsome and mitochondria fractions of the cell, and bound to protein with a molecular weight of about 70,000 daltons. The accuracy and clinical evaluation of CT, 67Ga-CS and their combined use were compared to those of bimanual pelvic examination. The diagnostic accuracy in differentiating between cystic and solid tumors was 77.9% by bimanual, 85.8% in CT, 75.2% in 67Ga-CS and 87.6% in combined use. The accuracy in differentiating between benign and malignant tumors was 74.3%, 88.5%, 92.0% and 94.7% respectively. The combined use of CT and 67Ga-CS could guarantee higher accuracy in diagnosis than bimanual pelvic examination, and was considered to be a valuable diagnostic method.

Female↗