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Biomedical subjects

S Nowak

Publications and source records attributed to S Nowak.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

[Cerebrovascular disorders in the urban population of Kielce: incidence and mortality in the years 1973-1974].

During 1973 and 1974 in the urban population of Kielce 528 verified new cases of cerebro-vascular disorders (CVD) were found. The average annual incidence rates reached 203 for males, 176--for females, and 189 for both sexes per (100,000) 181, 167 and 174 respectively when cases of transient ischaemic attack were excluded. The mortality rates in those cases were estimated to be 103, 82 and 92 respectively. Nearly 70 percent of all cases were admitted to neurological departments, and 14 percent remained at home. Age-adjusted incidence rates for subarachnoidal haemorrhage and cerebral embolism were three times higher, and the total incidence rate--twice higher than the rates estimated previously for the Warsaw population. It can be concluded that the incidence rates for CVD based exclusively on data from neurological departments are underestimated by at least 30 percent, and this bias varies according to the type of CVD. Prospective studies aimed toward evaluation of factors which can influence risk of development or death of CVD should be initiated.

Adolescent↗
PubMedDate not supplied

[Fibrin fibrinogen degradation products in the cerebrospinal fluid of neurological patients].

The authors determined FDP levels in the cerebrospinal fluid by the method of Merskey in 214 neurological patients and found raised levels in 58.6% of cases (from 0.1 to 8.0 ug/ml, with normal value range 0-0.5 ug/ml). In the control group the FDP levels in the CSF were normal. No correlation was noted between the FDP levels in the CSF and in blood. Raised CSF FDP level was observed in exacerbations of multiple sclerosis, strokes especially of embolic origin, syringomyelia, bulbar form of amyotrophic lateral sclerosis, epilepsy, migraine, lumbar disc lesions, polyneuropathy, parkinsonism, brain atrophy, after craniocerebral trauma, in Kleine-Levin syndrome. The authors are studying now the course of FDP changes in the CSF in various cases in the aspect of clinical-laboratory correlations.

Adult↗
PubMedDate not supplied

[Symptoms accompanying epileptic attacks].

The author analysed 124 cases of grand mal seizures in patients aged above 16 years observed for 2 to 15 years finding sporadic tongue or oral mucosa biting in 55.7% of cases, involuntary passing of urine in 49%, simultaneous occurrence of both these signs in 37% defection in 8.1%, ejaculation in 1.6%, conjunctival o cutaneous ecchymoses in 29.8%, and significant traumas in 20.2% (72% of these cases were men). Assuming that these signs occurred as a rule during each attack these per cent proportions were as follows: 17.7%, 15.3%, 9.7%, 2.4%, 0.8%, 10.5% and 2.4% respectively. Most frequently these signs appeared during the first attacks before treatment beginning, during attacks appearing after several years without seizures, after arbitrary stopping of drug taking and as a result of irregular treatment and alcohol drinking. In 14.5% of patients during observation lasting from 10 to 20 years no peri-ictal signs appeared. In a group of young unmarried people these signs were often concealed, while they were exaggerated by a small group applying for disability pension or wanting to have that pension increased. Patients from rural areas seemed to give less attention to these concomitant signs.

Adolescent↗
PubMedDate not supplied

[Late epilepsy among the population of Kielce and selected communities in Kielce province].

The authors defined the morbidity index of late epilepsy (MI) on the ground of notified cases in the population aged over 20 years (with first seizure past the age of 20 years) comprising 228273 individuals (125453 living in towns and 102820 living in villages) in the years 1979-1980. The index was calculated per 1000 of the population. The general index was 2.23 (males--2.77; females--1.72). The value of the index was highest in the age group 20-29 years (3.75) and 40-49 years (2.58) in males, and in females this value was also at its peaks in these age groups (2.63 and 1.93, respectively). In the whole population the index had also two peaks in these age groups: 3.21 and 2.55 respectively. In the urban population the general index was 2.33 (2.77 in males and 1,91 in females) being again highest in the age groups 20-29 and 40-49 years. Similar peaks were found in these age groups in the urban male and female populations. In the rural population the general index was 2.11 (males 2.77, females 1.49) and the peaks were in the age groups 20-29 and 30-39 years. In males these peaks were in the age groups 20-29 and 40-49, and in females in the groups 20-29 and 30-39 years. The lowest index value was in the age group over 60 years in the whole population (1.22), in the urban population (1.62 and in the rural population (0.91). In further studies on epilepsy the method of active search for epilepsy cases with full clinical and epidemiological analysis is being used.

Adult↗
PubMedDate not supplied

[A case of hematomyelia].

The authors report haematomyelia developing in a 43-year-old man following a slight spinal trauma. The clinical course was severe but the prognosis was good.

Adult↗
PubMedDate not supplied

[Analysis of trace element concentrations in the cerebrospinal fluid using particle-induced X-ray emission].

The authors used for first time the PIXE method ("particle induced X-ray emission") for determination of the concentration of in the cerebrospinal fluid of neurological patients. In 40 hitherto examined patients with epilepsy, multiple sclerosis, extrapyramidal syndromes, Little's syndrome, Guillain-Barré syndrome, cerebral strokes, tumours of brain and spine, vasomotor headaches, neuralgia and discopathy, the concentration of the following trace elements was determined: Br, Zn, CU, Pb, Rb, Fe, Ca, K, Cl, Sr, Zr, Cr, Mn, Ni, As. The ranges of the determined concentrations in ppm units mean values and mutual relations of some elements were presented. The concentration of trace elements in cerebrospinal fluid was lower than in the tissues. The authors continue further investigations in many neurological syndromes with analysis of various clinico-laboratory correlations.

Adolescent↗
PubMedDate not supplied

[Klein-Levin syndrome (case report)].

The authors observed the syndrome in a 17-year-old boy weighing 86 kg and training weight-lifting. During between 10 and 20 months he had periods of physiological sleep lasting on the average 7 days, with voracious appetite and dysphoris. In the EEG tracings corresponding to physiological sleep were observed during the somnolence period, later in transient changes appeared, mainly in the forebrain. EDP in the cerebrospinal fluid was raised - 0.4 micrograms/ml (normally 0--0,05 micrograms/ml according to Merskey). The results of other laboratory investigations were normal. Since about 3 months the patient has been completely healthy and his scholastic progress in good. The authors suspect that excessive exertion may be a causative factor in this syndrome when it occurs at the time of adolescence.

Adolescent↗
PubMedDate not supplied

[Giant cell tumors of vertebral column].

Between 1962 and 1993 were treated at the Department of Neurosurgery, Medical Academy in Poznań 11 patients (10 women and 1 man) with giant-cell tumours of the spine. Their mean age was (26.27 +/- 17.56) years. In all patients pain was the presenting symptom and 10 had neurological deficits. The cervical, thoracic and lumbo-sacral spine was involved; 9 patients were treated surgically and 3 patients received adjuvant radiotherapy. The follow-up time was from 2 months to 30 years.

Adolescent↗
PubMedDate not supplied

[Levels of free fatty acids in plasma, tissue utilization coefficient of glucose K and insulin secretion following intravenous glucose load in hyperthyroid patients treated with propranolol or acebutolol].

The study aimed at determining relationship between plasma free fatty acid (FFA) and impaired glucose tolerance in hyperthyroid patients prior to and after the treatment with propranolol or acebutolol, i.e. following lipolytic blockade leading to a decrease in plasma FFA levels. The study included 31 untreated hyperthyroid patients and 12 normal subjects serving as a matched control group. IVGTT was performed in all subjects. Venous blood specimens were collected at 0, 3, 5, 15, 30, 60, and 120 minutes following intravenous glucose load (0.33 g/kg body weight during 3 minutes). Nineteen patients with normal K values were randomized to groups treated either with propranolol in the daily dose of 120 mg (10 patients) or 400 mg acebutolol (9 patients). Twelve patients with low K values were randomized to groups treated with either propranolol (5 patients) or acebutolol (7 patients). The second IVGTT was performed after 7 days of therapy. Glucose, FFA and insulin levels were determined in all blood samples whereas T3 and T4 were determined in samples taken at 0 minute. Plasma T3, T4 and insulin levels were assayed with radioimmunological technique, glucose--with glucose oxidase, and FFA--colorimetrically. Significantly higher plasma FFA levels were found in patients with low K values in comparison with control group. There were no differences in plasma FFA levels in both hyperthyroid patients and normal subjects. Acebutolol but not propranolol normalized K value whereas propranolol (but not acebutolol) significantly decreased acute phase of insulin secretion. Plasma glucose and insulin levels as well as K value were not altered during propranolol acebutolol therapy in patients with normal K value.(ABSTRACT TRUNCATED AT 250 WORDS)

Acebutolol↗
PubMedDate not supplied

[Central nervous system trauma in children. Clinical analysis of 782 cases].

A series of consecutive 782 children with severe head trauma and spinal cord injury who were managed surgically or conservatively in the Department of Neurosurgery, Medical Academy in Poznań during 31 years was analysed. The clinical history, severity of injury (scales AIS, ISS), outcome of head and spinal cord injuries are reviewed. Factors important in predicting a poor outcome included the presence of brainstem contusion, intracranial haematomas and complete and severe partial spinal cord lesions.

Adolescent↗
PubMedDate not supplied

[Factors contributing to recurrence of intracranial meningiomas and indications to postoperative radiotherapy].

The incidence of various histological subtypes of intracranial meningiomas and recurrences was examined in 565 patients with surgically treated meningiomas in the Department of Neurosurgery in Poznań, between 1960-1992. Approximately 60% of the tumours were located on the convexity (39.5%) and parasagitally (23%). Histological diagnosis in 88% of the patients was endotheliomatous (61%), fibroblastic (17%) and angiomatous (10%) meningiomas. The incidence of recurrence after complete removal of the meningioma was 7% for all sites, but much higher after partial removal. Among the recurrences, there was a higher degree of malignant and angiomatous subtypes. Surgery is the accepted form of treatment for meningiomas but it may prove insufficient as the only method of therapy in certain situations. Implications for the potential role of postoperative radiation therapy are discussed.

Adolescent↗
PubMedDate not supplied

[Occurrence of tumors in the anterior part of the third ventricle and in adjacent structures in patients of the Department of Neurosurgery, Medical Academy in Poznan].

A group of 159 patients with tumours in the anterior part of the third ventricle and surrounding region were analysed. According to WHO classification the tumours belong to groups I, V, VI and VII. The assessment of neurological manifestations and hormonal abnormalities makes possible their early diagnosis. CT of the head and MRI inform about the location, character and extent of the intracranial mass. Angiography provides important information on the vascularization of the tumour and its relation to the vessels of the anterior part of Willis circle and hypothalamic veins. In the surgical treatment in 37 cases microsurgery was used reducing the perioperative mortality by half. Hydrocephalus associated with the tumours was treated either by atrioventricular drainage or, when the tumour was partly removed, pellucidotomy was done. Radiotherapy was the next stage in the treatment of tumours of this location.

Adult↗