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Biomedical subjects

S Nomoto

Publications and source records attributed to S Nomoto.

At least 181 records · Page 10Linked to original sources
PubMed1981

Experience with free composite tissue transplantation based on the deep circumflex iliac vessels.

Eight free iliac osteocutaneous flaps and three vascularized iliac bone grafts based on the deep circumflex iliac vessels were transferred in 11 cases of large skin and bone or bone defects. Seven of the eight osteocutaneous flaps took successfully. The eighth demonstrated partial necrosis. There was complete bone union in ten cases, and no union in one case as a result of persistent infection. Based on this experience, we concluded that free osteocutaneous flaps based on the deep circumflex iliac vessels have the following advantages over free osteocutaneous flaps based on the superficial circumflex iliac vessels: the pedicle is long (5 to 7 cm); the nutrient vessels are large (artery: 2.2 mm; vein: 2.5 mm); the anatomic course of the vessels is constant; and there is a large amount of bone available.

Adolescent↗
PubMed1981

Subclinical changes in brain morphology following cardiac operations as reflected by computed tomographic scans of the brain.

Effects of cardiopulmonary bypass (CPB) and hypothermic circulatory arrest on brain morphology were evaluated by computed tomography (CT). Of 57 children undergoing cardiac operations, 45 (4.5 +/- 2.8 years of age) were operated upon with the use of CPB with high-flow, mildly hypothermic perfusions. Twenty-seven of them were perfused with bubble oxygenators and 18 with membrane oxygenators. In the bubble oxygenator group, all 14 with 20 mu filters in the arterial line showed no postoperative CT changes, whereas four of 13 (31%) with 40 mu filters or without filters showed decreases in brain mass on CT scans. Three of these four patients underwent perfusion for more than 80 minutes. There were no CT changes in the membrane oxygenator group. Twelve infants (10.4 +/- 4.5 months of age) were operated upon with the aid of deep hypothermia and circulatory arrest (core temperature below 20 degrees C). Ten of 12 who had circulatory arrest for less than 60 minutes showed no CT changes, but two infants who had circulatory arrest for more than 60 minutes showed changes similar to those described above. All six children with CT changes had no clinical manifestation of the brain damage, and their CT abnormalities recovered within 6 to 11 months after operation. The specific cause of these changes remains undetermined, but microemboli or hypoxia during operation could be implicated.

Brain Diseases↗
PubMed1980

Pulmonary and systemic hemodynamics during hemorrhagic shock in baboons.

The pulmonary and systemic hemodynamic response to four hours of hemorrhagic shock and resuscitation has been studied in 17 baboons using both open and closed chest models. No pulmonary artery (PA) hypertension occurred during shock or resuscitation except for an increase in lft ventricular end diastolic pressure (LVEDP) secondary to intravascular volumee overload with Dextran. Pulmonary vascular resistance (PVR) increased during shock but returned to control levels with reinfusion of shed blood and correction of acidosis. PVR was moderately elevated following reinfusion of shed blood if acidosis was not corrected or if volum resuscitation was inadequate. No increase in gradients occurred between PA pressure and left atrial (LA) pressure or LVEDP and there was no gradients between small pulmonary vein and LA pressure. Arterial PO2 uniformly increased during shock and remained at or above control levels of reinfusion. Gross or histologic evidence of "congestive atelectasis" or "shock lung" was not observed. These observations suggest that in the subhuman primate, hemorrhage alone does not produce significant injury to the lung during shock or the immediate postresuscitation interval. Hemorrhage alone did not produce changes in the lung which would result in increased pulmonary microvascular hydrostatic pressure following appropriate resuscitation.

Animals↗