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Biomedical subjects

S Noda

Publications and source records attributed to S Noda.

At least 235 records · Page 13Linked to original sources
PubMed1988

Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.

Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.

Aged↗
PubMed1988

Affinity of drugs for dopa-auto-oxidation melanin and tyrosinase-catalyzed dopa-melanin in vitro.

We examined spectrophotometrically the ability of drugs to bind with dopa-auto-oxidation melanin or tyrosinase-catalyzed dopa-melanin. Each drug, at 5 X 10(-5) M, was incubated at 37 degrees C for 8 h with 0.4 mg of synthetic melanins in 20 mM potassium phosphate buffer at pH 7.0 or in 20 mM acetate buffer at pH 4.8. Chloroquine, thioridazine, befunolol, pindolol, daunomycin and 5-fluorouracil bound to melanin at pH 7.0 and 4.8. Methotrexate bound to melanin at pH 4.8, but not at pH 7.0. Pilocarpine, epinephrine, acyclovir, vincristine and colchicine did not bind to dopa-auto-oxidation melanin or tyrosinase-catalyzed dopa-melanin.

Catechol Oxidase↗
PubMed1988

Herpes zoster ophthalmicus complicated by hyphema and hemorrhagic glaucoma.

We treated two patients with herpes zoster ophthalmicus in whom hyphema and hemorrhagic glaucoma occurred. Case 1 complained of facial skin eruption, and was given intravenous acyclovir for 7 days. Hyphema and high intraocular pressure occurred in the left eye 10 days after the onset of the skin eruption. Case 2 had severe pain and blisters on her face, and was given intravenous acyclovir for 7 days. An intracameral hemorrhage and glaucoma developed in the right eye 15 days after the onset of the skin lesion. Intravenous acyclovir may be necessary for longer than 7-day periods if the iridocyclitis remains.

Acyclovir↗
PubMed1988

Effect of mass chemotherapy and piped water on numbers of Schistosoma haematobium and prevalence in Bulinus globosus in Kwale, Kenya.

From June 1982 to May 1986 in a small village in Kwale, Kenya, we studied seasonal fluctuations in populations of Bulinus globosus, prevalence of Schistosoma haematobium infection in this snail, and effects of chemotherapy and piped water supply on infection rate of snails. In the perennially-flowing Pemba River, relatively small numbers of snails were collected; they were found only during the hot dry season (December to March). In a tributary stream, the Kadingo River, whose flow ceased at the end of both the cool and hot dry seasons, snail numbers peaked at the end of the cool dry season (October to November) and at the beginning of the hot dry season (January). Large numbers of infected snails were found in the Kadingo River from November to January (short rainy season and beginning of dry season). Selective mass chemotherapy with metrifonate and provision of piped water were begun in February and March 1984. These control measures achieved a significant reduction in the infection rate of snails (P less than 0.001); the annual infection rate for the 2 years before treatment was 9.3% and 13.1%, and for the 2 years after treatment was 3.5% and 3.4%.

Animals↗
PubMed1988

Efficacy of metrifonate in a highly endemic area of urinary schistosomiasis in Kenya.

In a community in Kwale district, Kenya, selective mass chemotherapy with metrifonate caused a marked reduction in the intensity of Schistosoma haematobium infection from 46.5 to 9.4 eggs/hr and a sharp fall in prevalence of gross hematuria from 18.3% to 5.1%, although overall prevalence was reduced only slightly from 67.4% to 54%. The effect of metrifonate on cure rate and reduction of infection intensity was limited by both age and pretreatment infection intensity. Rate of improvement from gross hematuria was similar in all ages and in all classes of intensity of infection. Two doses of metrifonate reduced the prevalence of gross hematuria as much as 3 doses did, while the effect of a single dose on morbidity remains to be clarified.

Age Factors↗
PubMed1988

[Long-term chemotherapy in patients with stage IV gastric cancer after surgical treatment--a randomized comparative study of FT-207 and UFT].

A prospective randomized and comparative study of FT-207 and UFT was performed for cases of Stage IV gastric cancer involving long-term cancer chemotherapy after surgery. Immediately after the surgery, the subjects were randomly divided into two groups: A group treated by MMC and FT-207: and B group treated by MMC and UFT. From a total of 54 cases, 8 cases were excluded, so that A group consisted of 24 subjects and B group of 22 subjects. There were no differences in background factors between the two groups. In a comparison of all the cases, B group revealed a significantly higher survival rate than A group. These results indicated that the simultaneous use of MMC and UFT was effective as a long-term cancer chemotherapy after surgery for patients with Stage IV gastric cancer.

Adult↗
PubMed1988

Effect of drugs in vitro on lysosomal enzyme activities in bovine retinal pigment epithelial cells.

We examined in vitro the effect of several drugs on the activities of lysosomal enzymes in the crude extract of bovine retinal pigment epithelial cells. Acid phosphatase, beta-D-glucuronidase, N-acetyl-beta-D-glucosaminidase, alpha-L-fucosidase, and alpha-D-mannosidase were used as lysosomal enzymes. Sodium iodate at 10(-6), 10(-5) and 10(-4) M, and potassium iodate at 10(-5) and 10(-4) M inhibited acid phosphatase activity. Ferrous chloride at 10(-5) and 10(-4) M suppressed beta-D-glucuronidase activity. Ferric chloride, indomethacin, chloroquine, chlorpromazine, 5-fluorouracil, tobramycin, daunomycin, oxalate and epinephrine had no or only minimal inhibitory effects on the lysosomal enzyme activities examined.

Animals↗
PubMed1988

Effect of hydrocortisone on the development of embryonic chick duodenum--transmission electron microscope studies.

The effect of hydrocortisone on morphological changes in developing chick embryo was observed by transmission electron microscopy and immunohistologically with antiserum of actin. The morphological changes were more remarkable in the hydrocortisone-dosed 19th day embryonic duodenum. This hormone caused increase in the height and length of microvilli in absorptive epithelial cells. The development of organella such as Mitochondria, Golgi's apparatus and endoplasmic reticulum in the absorptive epithelial cells were enhanced. Injection of this hormone also induced an increase in microfilamentus bundles in the microvilli of absorptive epithelial cells. These morphological features of hydrocortisone-dosed 19th day embryonic duodenum indicated similar ones to the chicken at the stage of normal just hatching or 1st day after hatching. These results strongly support the previous suggestion that hydrocortisone may be one of the important factors regulating normal development in chick embryonic duodenum and may exert a major influence on the rapid growth and maturation of absorptive epithelial cells.

Actins↗
PubMed1987

Ocular symptoms of moyamoya disease.

We examined four patients with moyamoya disease who had ocular symptoms. The diagnosis of the disease was based on an abnormal vascular network in the cerebral basilar region, observed by carotid angiography. One patient had amaurosis fugax. A second patient demonstrated bilaterally decreased visual acuity and visual spatial agnosia. The other two patients had homonymous hemianopsia; one also had transient diplopia and the other had temporal pallor of the optic disks. We found that patients with moyamoya disease exhibited various ocular symptoms but had few abnormal intraocular findings.

Adult↗
PubMed1987

Lysosomal enzymes in tear fluids from patients with Terrien's marginal corneal degeneration.

We examined biochemically the lysosomal enzyme activities in tear fluids from patients with mild myopia, senile cataract, and Terrien's marginal corneal degeneration. Tear acid phosphatase activities in Terrien's degeneration were almost the same as those in mild myopia and senile cataract, while those of N-acetyl-beta-D-glucosaminidase in Terrien's degeneration were higher. The high activity of tear N-acetyl-beta-D-glucosaminidase may be derived from the lacrimal gland and infiltrate histiocytelike cells in Terrien's marginal corneal degeneration.

Acetylglucosaminidase↗