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S Nanko

Publications and source records attributed to S Nanko.

121 records · Page 7Linked to original sources
PubMed1979

Studies on pituitary-gonadal endocrine function in XYY men.

Serum luteinizing and follicle-stimulating hormones and testosterone levels were studied in 11 patients with 47-XYY chromosomes and a comparison was made to normal men and patients with other testicular diseases, including Klinefelter's syndrome. Serum follicle-stimulating hormone levels in patients with XYY chromosomes were elevated significantly in comparison to those in normal men but lower than those in men with Sertoli cell only syndrome and Klinefelter's syndromes. Serum luteinizing hormone levels were somewhat elevated and serum testosterone levels were somewhat low in comparison to normal men, although the difference was not significant. Results of the short-term human chorionic gonadotropin stimulation test suggested almost normal Leydig cell reserve capacity in patients with XYY chromosomes.

Adolescent↗
PubMed1979

Personality traits of 47,XYY and 47,XXY males found among juvenile delinquents.

The mental features of nine 47,XYY males and six 47,XXY males found among Japanese juvenile delinquents were examined. The results of intelligence tests suggested a slight impairment among 47,XYY and 47,XXY males. The psychiatric interviews and the psychological tests revealed that 47,XYY males had a high activity level while 47,XXY males had a low one. Analyses of the offense type and psychophysiological features supported these findings. As the activity level is considered to be largely determined genetically, the extra Y is suspected to be responsible for the high activity level and the extra X in males to be responsible for the low activity level.

Adolescent↗
PubMed1979

Prolonged P-R interval in a male with 47,XYY karyotype.

A 47,XYY male with an extremely prolonged P-R interval (0.42 sec) on the electrocardiograph is described. There was also a secondary R wave in lead V1. He had no past history of heart disease and no cardiac abnormality on physical examination.

Adolescent↗
PubMed1979

Dermatological study of 47,XYY males.

Dermatological features of five 47,XYY males are presented. Port-wine stains were observed in 2 cases. As the incidence of port-wine stains among the general population is believed to be 0.5%, this result would seem to indicate that the association of 47,XYY males with port-wine stains is more than a coincidence, though the survey of previous studied failed to reveal any 47,XYY cases with port-wine stains.

Acne Vulgaris↗
PubMedDate not supplied

Pericentric region of chromosome 9 is a possible candidate region for linkage study of schizophrenia.

We have undertaken a systematic G-banding survey to find structural chromosomal abnormalities among patients with schizophrenia. Of 120 patients with DSM-III-R schizophrenia, four (3.3%) had a pericentric inversion of chromosome 9 and three (2.5%) had a X/XX mosaicism. The frequency of pericentric inversion of chromosome 9 among patients with schizophrenia was statistically higher than those among newborns and Asian populations. Our results indicate that the pericentric region of chromosome 9 might be one of the potential regions of interest for linkage analysis of schizophrenia.

Adolescent↗
PubMedDate not supplied

Relationship between impairment of prenatal brain growth and family history of psychosis in schizophrenia.

Recently McNeil et al. (1993b), showed that schizophrenics had smaller head circumference (HC) at birth than controls. This small head size at birth was observed more commonly among schizophrenics without a family history of psychosis than among familial schizophrenics, suggesting that some prenatal environmental factors, rather than genetic factors, are related to the impaired brain growth in utero. We attempted to replicate this finding in 100 Japanese schizophrenics (DSM-III-R), using contemporaneous data on body measures at birth. Conversely, in the current study, HC at birth was found to be significantly smaller in schizophrenics with a family history of psychosis (N = 19) than those without (N = 81). A multiple regression analysis, controlling for gender, gestational age, maternal age, birth order and year of birth, yielded an overall reduction of about 1 cm in HC at birth among familial schizophrenics compared with non-familial schizophrenics. When HC at birth in family history positive and negative groups was compared separately with the local population norms with adjustment for gender and gestational age, familial and non-familial schizophrenics were both found to have significantly smaller HC at birth, although the difference was less marked for the latter. These results suggest that schizophrenics have delayed cerebral development in utero, and that genes which operate on prenatal neurodevelopment may play an important role in the aetiology of schizophrenia, although it is possible that some environmental factors may also be involved in the impaired brain growth.

Adult↗
PubMedDate not supplied

Season of birth of chronic alcoholics.

Season of birth has been well studied in mental illnesses, such as schizophrenia and affective disorders; however, only a few studies have been done for alcoholism. Recently Modestin et al. (1995) found, in a sample from Switzerland, excess birth of male alcoholics in March to July, compared to the general population. The present study attempted to replicate their finding in two independent Japanese samples which comprised a total of 1,947 men with chronic alcoholism. In our study, no birth rate excess in March to July was observed in either sample, while a non-significant birth rate excess (12%) in August to October was noted. It is concluded that there is no consistent trend in season of birth of alcoholics across countries.

Adult↗
PubMedDate not supplied

Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder.

There is some evidence suggesting that a polymorphism of variable number of tandem repeats (VNTR) in the second intron of the serotonin transporter (5-HTT) gene and another variation which lies 1.2 kb upstream of the promoter of the gene (5-HTTLPR) are associated with affective disorders. However, conflicting results have also been reported. We examined an allelic association of these two polymorphisms in a Japanese sample of 191 patients with affective disorders (142 bipolar and 49 unipolar) and 212 controls. Substantial differences in the number and frequency of alleles between Caucasians and Japanese were observed for both polymorphisms. A significant association between the VNTR polymorphism and bipolar disorder (genotypic association: odds ratio 2.2, 95% CI 1.2-4.0; allelic association: odds ratio 1.7, 95% CI 1.0-3.0) was found, but not between the 5-HTTLPR polymorphism and bipolar disorder. No significant association with unipolar depression was detected using either genetic marker, although this may be attributable to the relatively small number of subjects with unipolar depression. Our results suggest that the VNTR itself or another unknown functional polymorphism which would be in linkage disequilibrium to the VNTR has an effect on susceptibility to bipolar disorder.

Adult↗
PubMedDate not supplied

No evidence for linkage between schizophrenia and eight microsatellite markers on chromosome 19.

We report the results of a linkage study of eight markers on chromosome 19 in a sample of 24 families multiply affected with schizophrenia and related psychoses. This study forms part of a systematic search of the entire genome using microsatellite markers spaced at 10-20 cM intervals. These data provide no evidence for the presence of a gene of major effect on chromosome 19 under the assumption of genetic homogeneity or heterogeneity. We have attempted to describe the extent to which this region has been excluded and demonstrate that while it is possible to exclude near-dominant and recessive models under the assumption that all families are linked to the same locus, power for exclusion falls away rapidly when incomplete penetrance and heterogeneity are invoked.

Chromosomes, Human, Pair 19↗