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Biomedical subjects

S Nanko

Publications and source records attributed to S Nanko.

At least 109 records · Page 6Linked to original sources
PubMed1993

Reproductive rates in schizophrenic outpatients.

We investigated the marriage rates, the reproductive rates and the marital reproductivity of schizophrenic outpatients in Japan. A total of 553 patients with DSM-III-R-diagnosed schizophrenia at the Teikyo University Hospital, Tokyo, Japan were compared with age- and sex-matched outpatients at surgical clinics of the same hospital. Our findings indicate that the reproductivity of schizophrenics is reduced, even though the sample consists of outpatient population and modern operational diagnostic criteria have been used. The marriage rate and reproductive rate of the schizophrenics were reduced, especially in men. The number of married men was significantly less than that of married women and the reduced marital reproductivity was found in women but not men. These findings indicate that the reduced reproductivity of men in accounted for largely by a reduced rate of marriage, and that in women is accounted for partly by lower rate of reproductivity within marriage.

Adult↗
PubMed1993

[Schizophrenia following prenatal exposure to influenza during second trimester].

Mednick et al and O'Callaghan et al have recently reported that individuals exposed to the 1957 A2 influenza pandemic during their second trimester in utero are at risk for later schizophrenia. In this study, we determined whether their findings could be reproducible in a Japanese sample. In Japan, there were two waves of the 1957 A2 influenza pandemic; the first occurred from June to July, and the second from November to December. In addition, an epidemic of influenza A/B mixed type prevailed from January to February 1957. We obtained information on all dates of birth of 1187 individuals born between June 1955 and May 1960, who were treated for schizophrenia during the study period. November 1991 to September 1992, at 18 mental hospitals around Tokyo metropolitan areas. Hospital clinical diagnosis was used. We defined the index year from June 1957, beginning the first wave of the pandemic, to May 1958. We compared the number of schizophrenic births in each month of the index year with the average number of births in the corresponding month of the two years before, and following, the index year. The observed number of births in June 1957 and April 1958 were found to be significantly high compared with the average number of births for the corresponding month in the four control years. The 63% excess of schizophrenic births in June 1957 ensued about 5 months after the peak of influenza A/B mixed type epidemic; there was also 49% increase in births about 5 months after the second wave of the pandemic. Given that full term delivery occurred in our sample (ie, 9 months pregnancy), our results support the view of Mednick et al and O'Callaghan et al that maternal exposure to influenza in the mid-pregnancy increases the risk of developing schizophrenia.

Disease Outbreaks↗
PubMed1992

Linkage study of schizophrenia with markers on chromosome 11 in two Japanese pedigrees.

We examined the linkage between schizophrenia and DNA markers on chromosome 11 in two Japanese pedigrees. Thirty individuals from the two pedigrees were genotyped at the eleven polymorphisms (eight loci) studied. Data were analyzed according to three models, representing a range of single gene models from near dominant to an intermediate model. For all markers, except those at the D11S35 locus, there is no evidence for the linkage. Positive LOD scores between 1 and 1.5 are obtained for some genetic models with the polymorphism at D11S35. Two point scores for the broad diagnostic model and for the intermediate parameter set peak at 1.49.

Chromosome Mapping↗
PubMed1991

Linkage analysis of affective disorder using DNA markers on chromosomes 11 and X.

We have investigated two pedigrees in an attempt to detect the putative linkages between affective disorder and c-Ha-ras-1 oncogene and the insulin gene on chromosome 11, or hypoxanthine phosphoribosyltransferase (HPRT) on X chromosome. The linkage between affective disorders and the markers on chromosomes 11 and X was ruled out with the assumption of no recombination.

Bipolar Disorder↗
PubMed1988

Blood groups and affective disorders.

Distributions of seven blood groups (ABO, MNSs, P, Rh, Duffy, Kidd and Xg) were studied in a total of 118 Japanese patients with affective disorders. The patients were diagnosed according to the DSM-III: (1) Major Depression (= Unipolar Disorder, UP) (2) Bipolar Disorder (BP) and (3) Other Affective Disorders. The following results were found: (1) a high frequency of the B blood group in all patients with affective disorders compared with controls; (2) a high frequency of the Fy(a+b+) and a low frequency of the Fy(a+b-) in all patients with affective disorders, UP and BP compared with controls; (3) a low frequency of the Jk(a+b+) and a high frequency of the Jk(a+b-) in BP compared with controls and with UP.

Adult↗
PubMed1985

Homicidality in a woman with a 47,XXX karyotype.

The 47,XXX karyotype is a rare sex chromosome anomaly. A female with this karyotype is called a triple X or superfemale. This karyotype is usually not associated with a characteristic mental or physical phenotype. A 19-year-old female who committed homicide and was found to have a 47,XXX karyotype is described, and the possible correlation between sex chromosome anomalies and psychopathology or criminality is discussed.

Adult↗
PubMed1982

Cytogenetic studies in a Y-to-X translocation observed in three members of one family, with evidence of infertility in male carriers.

A family is reported in which the mother and two sons are carriers of a Y-to-X translocation, der (X)t(X;Y) (p22;q11). All the the three carriers have short stature and disproportion of extremities, but otherwise normal phenotype. One of the sons, the propositus, has been affected with schizophrenia. Evidence was obtained that male carriers are probable sterile; both sons aged 26 and 30 years had azoospermia and the biopsied specimens of the testis had histologic pictures showing spermatogenetic arrest. The mother was H-Y weakly positive, and the normal X chromosome was inactivated in the majority of the cells analyzed. Dermatoglyphics of the three carriers were unusual and dissimilar to the features of Turner's syndrome. The clinical and cytogenetic findings in the present study are compared with those of the previously reported familial cases, and the genetic background causing phenotypic abnormalities in the male and female carriers is discussed.

Adult↗
PubMed1982

[Suspected cases of familial Alzheimer's disease-a case report and a study on aneuploidy in leukocytes (author's transl)].

Sibling cases of probable familial Alzheimer's disease were presented. Although familial occurence of Alzheimer's disease has been reported and relatively well known in the western literature, little attention has been paid to the matter in Japan. Some of the clinical features of our cases, for example, an earlier onset and focal neurological signs, are in good agreement with those of the previously reported cases of familial Alzheimer's disease. Possible involvement of vascular changes, such as amyloid or congophilic angiopathy was also suggested. An investigation for chromosomal abnormality in peripheral leukocytes from these patients, their healthy siblings and age-and sex-matched controls were carried out, revealing no significant differences in the frequencies of the hypo- or hyper- diploid cells among the three groups. Although chromosomal abnormalities in Alzheimer's disease, especially in its familial form, have gained considerable attention in relation to the dysfunction of the microtubules which is a proposed pathogenesis of the disease, the present results together with a few previously reported data 1,6,19) suggest that the familial Alzheimer's disease is not always accompanied with chromosomal abnormalities. Further extensive study is needed to clarify the precise relationship between Alzheimer's disease and the chromosomal abnormalities.

Adult↗
PubMed1979

Cervical radiculomyelopathy due to calcified ligamenta flava.

Two cases of cervical radiculomyelopathy were apparently caused by calcification of the ligamenta flava. Similar cases have not previously been described, although myelopathy due to calcified thoracolumbar ligamenta flava is occasionally reported. Radiological study is necessary for diagnosis. Surgical removal of the calcified masses was followed by improvement in the symptoms. In 1 patient, the disease was associated with pseudogout in the menisci of the knee joints, pubic symphysis, and acetabular lips. The cause and pathogenesis of this rare condition are unknown.

Aged↗