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Biomedical subjects

S N Ghosh

Publications and source records attributed to S N Ghosh.

At least 73 records · Page 4Linked to original sources
PubMed1978

H-Y antigen in human intersexuality.

The status of H-Y antigen was studied in 10 intersexual cases (three pure gonadal dysgenesis with XY genotype, three Klinefelter's syndrome, two true hermaphroditism with XX genotype, two male hermaphroditism) and in 18 normal adult subjects (nine males and nine females). In all these subjects, fluorescent staining and G-banding on chromosomes from cultured leukocytes confirmed their karyotype. Interestingly, H-Y antigen was found to be negative in XY females with dysgenetic gonads (PGD), while in the remaining intersexual states (viz Klinefelter's syndrome, true hermaphroditism and male hermaphroditism), it was found to be positive. These observations confirm that morphological differentiation of testis is controlled by H-Y antigen, and indicate that in the absence of the H-Y antigen, the gonad in pure gonadal dysgenetic patients (46, XY) could not be differentiated into testis, Further, it appears that H-Y antigen in no way influences the secretory function of testis.

Adolescent↗
PubMed1976

Oestradiol receptors in non-neoplastic gynaecomastic tissue of phenotypic males.

Cytoplasmic oestradiol receptors have been reported in breast tumor tissue but not in the uninvolved tissue from the same patients. Since gynaecomastic tissue is highly predisposed to neoplastic transformation, such receptors were looked for in this tissue from 13 phenotypic males of whom 6 had Klinefelter's syndrome. High affinity saturable binding (Kd approximately 10(-10) M) of 3H-oestradiol-17 beta was found in the breast tissue from 12 of these patients by gel elution and dextran-coated charcoal techniques. The concentration of binding sites were found to range from 16 to 359 fmol/mg cytosol protein. Previous studies by the present authors showing steroid aromatising capacity and the present finding of specific oestradiol receptors in a 'high-risk tissue' in the absence of any histologically detectable neoplasms might be relevant in elucidating the natural history of breast cancer in such individuals.

Adolescent↗