Search PubMed⌕ Search

Biomedical subjects

S N Ghosh

Publications and source records attributed to S N Ghosh.

At least 55 records · Page 3Linked to original sources
PubMed1981

Interferon (type-alpha and gamma) production by fresh and cryopreserved human mononuclear cells. Brief report.

A comparative study of interferon (IFN) production (type-alpha and gamma) was carried out using Ficoll-hypaque purified fresh and cryopreserved mononuclear cells from eight normal healthy individuals. Newcastle disease virus-NDV (R2B strain) was used as an inducer for type-alpha and Staphylococcal enterotoxin-A-(SEA) for type-gamma IFN production. There was no significant difference between the titres of type-alpha and gamma-IFN and lymphocyte subpopulations of fresh and cryopreserved mononuclear cells studied under identical conditions.

Adult↗
PubMed1981

Probable mechanism for the loss of Barr body in human female tumor with special reference to breast cancer.

One of the X-chromosomes by a random inactivation process condenses to form X-chromatin (Barr body) in early embryonic life. Once this occurs, it is final and fixed for that cell and all its descendants (1,2). However, numerous investigators have observed extreme variations in Barr body frequency in tumour cells. For example, Sohval and Gains (3) reported an absence of the characteristic Barr body pattern of 19 of the 27 teratomas from females and Moore and Barr (4) observed significant variation in Barr body counts in breast cancer cells. Furthermore, a good correlation was made between the frequency of Barr body and prognosis (5,6,7,8,9). From a retrospective study, it was shown that tumours with low Barr body frequency (BBF) had a significant correlation with blood vessel invasion (BVI) and poor prognosis (10). But the reason why patients with low BBF in the tumor with BVI get early recurrence is not known. In this paper an attempt has been made to suggest a mechanism which may be involved in reducing the BBF with high malignant potentiality.

Breast Neoplasms↗
PubMed1980

Further studies on the prognostic importance of Barr body frequency in human breast cancer: with discussion on its probable mechanism.

Based on the Barr body frequency, a total of 285 unselected breast cancer tissues were categorised as negative and positive tumours; incidence of these two groups in our series was 2:1, respectively. When 2-years' disease-free interval and 10-years' survival were considered, it was seen that patients harbouring negative tumours had significantly early recurrence and shorter duration of survival as compared to those having positive tumours. As vascular spread is the prerequisite of early recurrence, the shorter survival in the patients having negative tumours could be explained on the basis of blood vessel invasion, in that 73% of the negative tumours had blood vessel invasion, in contrast to only 24% in the positive tumours.

Breast Neoplasms↗
PubMed1979

Hormone dependency of rat mammary carcinoma--a comparison of two assay systems.

Succinic dehydrogenase activity of the DMBA induced tumor explants cultured with or without hormones was assessed histochemically while receptors for estrogen (ER) and progesterone (PgR) were estimated from the cytosol fraction of the tumor tissue. Tumor regression following ovariectomy (OVX) was kept as the end point for determining hormone dependency. By in vitro method positive correlation was observed in 5 of 6 responsive or hormone dependent tumors, and 13 out of 14 independent tumors. Presence of receptors (ER + PgR, PgR) correlated with responsiveness in 4 of 6 tumors while their absence in the non-responsive group correlated in 6 of 14 tumors. Prolactin responsive tumors did not regress following OVX even if ER + PgR or ER/PgR were present. Using the same tumor tissue the results of hormone dependency by the two methods were identical in only 9 of 20 tumors.

9,10-Dimethyl-1,2-benzanthracene↗