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Biomedical subjects

S Mukai

Publications and source records attributed to S Mukai.

At least 145 records · Page 8Linked to original sources
PubMed1989

[Use of Rokitamycin dry syrup in cases of upper deep cervical lymphadenitis and otitis media with exudatives].

Dry syrup of Rokitamycin (RKM.DS), a new macrolide antibiotic with 16-membered ring developed by Toyo Jozo Co., Ltd., was used on cases of upper deep cervical lymphadenitis (UDCL) and of otitis media with exudatives (OME) likely caused by chlamydia infections, and its clinical effects were investigated. 1) In four cases of UDCL (C. psittaci infections), daily doses of 20.0-28.6 mg/kg were administered for 10-42 consecutive days and good efficacies were observed with two cases of excellent results and two cases of good results. 2) In one case of OME (C. trachomatis infection) a daily dose of 30.0 mg/kg was administered for 15 consecutive days and good effectiveness was observed. 3) No side effect was observed in any of the cases. From the above results, it became clear that RKM.DS could effectively used as a therapeutic agent for UDCL and OME in children.

Child↗
PubMed1989

[Four cases of dysosmia with no vocal cords adduction during sniff (laryngeal dysosmia)].

The author first reported that the vocal cords adduct during sniff. This movement was observed both in normal and in anosmic subjects. In this paper four cases of dysosmia with no adduction of vocal cords during sniff was reported. The pattern of their olfactometry showed same tendencies, normal detective thresholds and inability of recognition and/or very low recognition threshold. With the observations and referenced articles, the author concluded that the vocal cord's adduction during sniff is a specific movement when the larynx concern with olfaction, and that the adductory movements is related to olfactory recognition. It was thought that the orbital cortex integrates the afferent stimulations from the larynx during sniff and olfaction from the nose. The author concluded also there exists these reported kind of dysosmia with no vocal cord adductory movement.

Adult↗
PubMed1989

[Laryngeal movements during wind instruments play].

Historically, the concern of wind instrumentalists has been diaphragm control and embouchure. Laryngeal movement during "blow" has been overlooked or neglected by wind musicians. It has been said that musical tone has to be produced by the resonances of the player's air column by opening his larynx during blow. In the present study, fiberscopic observations of the larynx during blow revealed that musical tones were played with adducted vocal cords. Narrowed glottis appeared to control the airflow of the blow. Persons who could not make musical tone blew with open glottis. Vibrato was also made by rhythmic open and narrowing movements of the glottis. The authors concluded that the larynx regulates the airflow of the "blow". The authors postulated that the embouchure might be important as the receptor of the airflow rather than controlling the movement for "blow".

Adolescent↗
PubMed1989

[Restoration of four missing upper-incisors with fixed bridges. I. A survey of fifty fixed bridges].

Four missing upper-incisors are usually restored in practice by both ways, fixed bridges and removable partial dentures. A survey of fifty fixed bridges for this type of missing teeth was conducted, in order to find out some points of caution when bridges are selected. The following results were obtained: 1. The average age of patients was 47 years old and the average life span of bridges was about 10 years. 2. Six-tooth fixed bridges extending from cuspid to cuspid, that is, bridges with two abutment teeth made up 70% of all bridges. 3. Band-crowns were used in the highest frequency (50%) retainers. 4. Various kinds of disorders were detected in the gathered bridges. Particularly recurrent caries and alveolar bone loss around the abutment teeth were remarkable. 5. Three-quarter crowns became uncemented in high frequency and therefore seemed to provide inadequate retention. 6. Regarding the contact of pontic with the ridge tissue, the effect of the material used was predominant to the form. 7. The upper incisors of pontic could play the role of guidance during protrusive movements with very little occurrences of disorder. 8. The occlusal support index of under 8 indicated a high possibility of various disorders afterwards.

Adult↗
PubMed1989

[Restoration of four missing upper-incisors with fixed bridges. II. Fabrication of fourteen fixed bridges].

In the previous study, fifty fixed bridges with four missing upper-incisors were gathered and analysed. As a result, several points of caution for restoring this type of missing teeth were obtained. In this study, the relationship of b/a ratio and marginal leakage was first investigated as a preliminary study and then fourteen fixed bridges were newly made upon these results. In addition, a follow-up study within 3.5 years was conducted. 1. Marginal leakage was closely correlative to marginal fit of crowns, that is, marginal leakage occurred at the portion of the crown margin having the thick layer of cement, and expanded to the lingual and/or distal side. 2. As b/a ratio became smaller, marginal leakage increased and especially expanded in the incisal direction. 3. Ceramometal crowns were estimated to be strong enough as retainers for restoring four missing incisors. 4. Ni-Cr alloy cast as one-piece manifested frictional fit just as with a precious alloy. 5. In the follow-up study, fracture of porcelain facing and excessive wear of occluding natural teeth were detected in one case each and gingival retraction or swelling of gingiva were perceived in three cases.

Chromium Alloys↗
PubMed1989

Studies on anti-liver cell membrane antibodies in sera of patients with autoimmune chronic active hepatitis.

In using the rat hepatocytes isolated and treated with formalin as antigen, IgG class antibodies to the liver cell membrane (LM-Abs) in sera of patients with chronic active hepatitis were examined by both indirect immunofluorescence (IF) and solid-phase enzyme immunoassay (EIA). Specificity of the reaction in IF and EIA was confirmed by an absorption test using different tissues and by inhibition test using the liver specific protein. Indirect IF test using isolated hepatocytes showed the linear staining in eight of 14 sera of patients with autoimmune chronic active hepatitis (CAH). Mean binding values and positive frequency of LM-Abs to the isolated hepatocytes which were detected by EIA were 4.18 +/- 2.99 and 71.4% (10/14) in autoimmune CAH, 3.16 +/- 2.50 and 50% (6/12) in primary biliary cirrhosis, 1.40 +/- 2.12 and 28.6% (4/14) in non-A, non-B, chronic hepatitis (NANB-CH) with serum gamma-globulin showing more than 2.0 gr/dl, 1.02 +/- 1.30 and 0% (0/13) in NANB-CH with gamma-globulin showing less than 2.0 gr/dl, 1.04 +/- 1.20 and 0% (0/15) in HB-CH, and 1.80 +/- 3.60 and 25.0% (3/12) in SLE. Titers of LM-Abs in serum of a autoimmune CAH patient decreased significantly after treatment with prednisolone, but their titers did not correlate with the activities of anti-nuclear antibodies or anti-smooth muscle antibodies. From these results, it was considered that some of NANB-CH patients with both LM-Abs and higher serum gamma-globulin more than 2.0 gr/dl might have some autoimmune characters similar to CAH.

Animals↗
PubMed1989

A functional new experimental biventricular model of heterotopic cardiac transplantation.

A heterotopic cardiac transplantation model in which the donor heart was able to maintain the systemic and pulmonary circulation of the recipient was devised, which did not require extracorporeal circulation or heparinization. All donor hearts in five pairs of adult mongrel dogs were resuscitated, and the systemic and pulmonary circulations maintained by the donor hearts alone were studied hemodynamically up to 3 hr after resuscitation, although long-term survival was not achieved.

Animals↗
PubMed1987

Site-directed cleavage of RNA.

Using complementary chimeric oligonucleotides containing deoxyribonucleotides and 2'-O-methylribonucleotides (1), enzymatically synthesized RNA (90 mer) were cleaved at a single site with Escherichia coli RNaseH, either at a hairpin loop or at a stem region. Especially, site-specific cleavage occurred in even the target region being enclosed within a stable, base-paired stem. The method is proved to be generally applicable to RNA containing secondary structures.

Base Sequence↗
PubMed1986

Loss of alleles at polymorphic loci on chromosome 2 in uveal melanoma.

The loss of alleles at loci on specific chromosomes in some malignant tumors, such as retinoblastoma and Wilms' tumor, suggests that recessive mutations are important in their oncogenesis. We postulate that similar mechanisms may be involved in the formation of uveal melanomas. We studied alleles at autosomal loci in uveal melanoma cells and in the constitutional cells from 19 patients who developed the tumors. We observed loss of alleles only at loci on chromosome #2. This suggests that recessive alleles at some chromosome #2 locus may be important in the oncogenesis of uveal melanomas.

Alleles↗