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Biomedical subjects

S Mue

Publications and source records attributed to S Mue.

At least 91 records · Page 5Linked to original sources
PubMed1979

Effects of adrenergic agonists and antagonists on immediate cutaneous reactions in bronchial asthma.

Asthmatic patients who showed an allergic skin reaction to house-dust antigen (HD) were injected intradermally with a mixture of HD and a various dose of isoproterenol (Isopr) or propranolol (Propr). In some cases Isopr clearly suppressed the formation of the wheal, but in some others Isopr did not much affect the allergic skin reaction. Also Propr increased markedly the skin reaction of some patients, or had little effect on it. The sensitivity of the skin of asthmatic patients to these drugs was closely correlated with the general response of the patients to adrenaline, such as changes in heart rate, diastolic blood pressure, blood glucose level, and blood triglyceride level.

Adrenergic Agonists↗
PubMed1979

The relationship between the arterial level of angiotensin-converting enzymes and arterial gas tension in bronchial asthma.

To study the mechanism which causes a lowered serum level of angiotensin-converting enzyme (ACE) in asthma patients, the changes in serum ACE in arterial blood gas tension was measured. Serum ACE was also determined in patients with chronic obstructive lung disease (COLD) and fibrosing lung disease (FLD). A reduced level of serum ACE was found in some patients with COLD, similar to that in patients with asthma. A significant relationship existed between the lowered serum ACE level and the degree of arterial hypoxia, especially in asthmatic patients and some patients with COLD. The significance of lowered serum ACE is discussed in relation to the pathogenesis and the mechanism of hypoxemia in patients with asthma, COLD and FLD.

Asthma↗
PubMed1979

Influence of metoprolol on hemodynamics and respiratory function in asthmatic patients.

Studies of metoprolol in asthmatic patients showed beta 1-selective blocking properties on the adrenergic receptor. Metoprolol in a dose of 40 mg given orally to 9 asthmatic patients significantly decreased the pulse rate at 60 and 120 minutes and the systolic blood pressure at 120 minutes but did not cause any increase of respiratory impedance, measured by the forced oscillation technique. A double-blind test was carried out to compare the effects of metoprolol and inactive placebo on the respiratory response to isoproterenol in 24 asthmatic patients. In the metoprolol group, systolic blood pressure decreased significantly and pulse rate at rest also tended to decrease. There was no significant difference between the metoprolol and placebo groups in the respiratory response to an isoproterenol aerosol.

Asthma↗
PubMed1979

The effect of sympathomimetic drugs on immediate skin reactions and metabolic responses in asthmatic patients.

The varied effects of intradermal injection of isoproterenol and propranolol on the immediate skin reaction were studied in relation to the metabolic responses to the intravenous injection of epinephrine. In asthmatic patients whose skin reaction was not suppressed with 10(-7) M isoproterenol, the hyperglycemic response after the injection of epinephrine was significantly reduced.

Adolescent↗
PubMed1978

Serum angiotensin converting enzyme level in bronchial asthma.

Using hippuryl-L-histidyl-L-leucine as a substrate analogue, serum angiotensin converting enzyme (ACE) was spectrophotometrically estimated in patients with bronchial asthma. The mean level of asthmatic patients was significantly lower than that of the control subjects. The reduced serum ACE activities did not change during an acute asthmatic attack. Significantly lower levels of serum ACE occurred in patients with chronic asthma than in those who only suffered with occasional asthma. Serum ACE activity was not reduced when the patients were taking steroids. Serum ACE activity could not be correlated with either the systolic blood pressure or the diastolic blood pressure of our asthmatic patients. However, serum ACE activity was correlated with the serum beta-globulin fraction in asthmatic patients.

Asthma↗
PubMed1977

Serum angiotensin converting enzyme activity in human bronchial asthma.

Using hippuryl-L-histidyl-L-leucine as a substrate analog, serum angiotensin converting enzyme (ACE) was spectrophotometrically estimated in patients with bronchial asthma. There were significantly low activities of serum ACE in 115 patients with bronchial asthma irrespective of the presence or absence of acute attack. The activity of serum ACE was reduced more markedly in the chronic type of bronchial asthma than in the paroxysmal type.

Asthma↗
PubMed1976

Leukocyte adenosine triphosphatase activity in human bronchial asthma.

Changes in adenosine triphosphatase (ATPase) activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Estimation of the leukocyte Mg++- and Ca++- dependent ATPases was carried out according to Hadden's method, incubating ATP with the membrane fraction of the leukocyte. The leukocyte ATPase activity was significantly elevated among asthmatic patients compared with control subjects. This elevated ATPase was seen in all asthmatics irrespective of acute attacks or the drug treatment. There was no clear correlation between the activity of ATPase and the percentage of leukocytes, neutrophils and eosinophils. There was no relationship between ATPase activity and adenyl cyclase activity of the same leukocytes from asthmatic patients.

Adenosine Triphosphatases↗
PubMed1976

Leukocyte cyclic-3', 5'-nucleotide phosphodiesterase activity in human bronchial asthma.

Changes in cyclic-3', 5'-nucleotide phosphodiesterase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Leukocyte phosphodiesterase activity was significantly elevated during asthmatic attacks. Elevated activity was seen in most active asthmatics irrespective of the drug treatment. The ratio of the adenyl cyclase activity to the phosphodiesterase activity of the same leukocyte decreased to less than 1.0 during asthmatic attacks.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1975

Bronchial hypersensitivity to methacholine in monkeys with beta-adrenergic blockade.

In monkeys with beta-adrenergic blockade caused by administration of propranolol, we found that the conductance of the total respiratory system markedly decreased following intravenous administration of methacholine. The presence of beta-adrenergic blockade was judged from inotropic effect on the heart, levels of blood glucose and lactic acid, and the reaction of eosinophils after adrenalin injection.

Animals↗
PubMed1975

Effects of beta-adrenergic stimulating and blocking agents on the adrenaline response and adenyl cyclase activity of leukocyte in monkey and human being.

Using the method in which leukocyte suspensions were incubated with NaF or metaproterenol at 30 degrees C for 15-30 min to allow them to convert 3H-ATP (10 muCi) to 3H-cyclic AMP, followed by separation of the formed 3H-cyclic AMP by common chromatography, the leukocyte adenyl cyclase activity of monkeys and human beings was measured with high reproducibility. The oral administration of metaproterenol increased the leukocyte adenyl cyclase activity which was stimulated by NaF and decreased the count of peripheral eosinophils in some of the monkeys. In the beta-adrenergic blockade of the monkey which was made by administration of propranolol, the leukocyte adenyl cyclase activity significantly decreased. The leukocyte adenyl cyclase from patients with coronary heart disease also decreased after oral medication with propranolol.

Adenylyl Cyclases↗
PubMed1975

Leukocyte adenyl cyclase activity in human bronchial asthma.

Changes in adenyl cyclase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Estimation of the leukocyte adenyl cyclase activity was carried out following in vitro stimulation by sodium fluoride (NaF) or metaproternol. The NaF-stimulated adenyl cyclase activity was significantly lower during asthmatic attacks. An oral administration of metaproterenol to patients during an attack was found to enhance the activity back to the control levels. Off-attack asthmatic patients showed a normal value which was again elevated considerably when they were administered metaproterenol. In contrast, measurements of adenyl cyclase activity using metaproterenol stimulation showed little change in patients in spite of asthmatic attacks or metaproterenol regimen. The lowering of the NaF-stimulated leukocyte adenyl cyclase activity was inversely proportional to the degree of lymphopenia during attacks and positively correlated with an increasing percentage of neutrophils.

Adenylyl Cyclases↗
PubMed1975

Acoustical studies on respiratory sounds in asthmatic patients.

Changes in the breathing sounds such as stridor and dry and wet rales in asthmatic patients were studied. The breathing sounds were recorded with the small transistor warp type microphone inserted through the nasal orifice into the trachea, main bronchi and segmental bronchi, and were analyzed with sound analyzer. The results were as follows: The whistling rales were caused by the resonance of the bronchial wall, when the vibrating frequency was coincident with its specific frequency. Snoring rales were explained as the sound caused by the air flow passing promptly through contracted bronchi with little secretion. Resonance of either bronchial wall or highly viscous sputum was considered to be responsible for the sonorous rales. Sibilant rales were audible when bronchi promptly repeated dilation and contraction. Stridor was picked up at the upper part of the air tract, from the main bronchus to the trachea, and noise was the main component on the sonogram, presumably caused by the air turbulence due to the narrowing and deformity of bronchial tube or to the sputum adhering to the inner surface of the air tract.

Adolescent↗
PubMed1975

A new electrode for electromyographic study of bronchial smooth muscle.

The contribution of the bronchial smooth muscles to asthmatic attack has been supposed by many studies such as measurement of the intrabronchial pressure and bronchographical studies, but electromyographical evidence has not been established yet. A new bipolar platinum-ring electrode fixed on polyethylene catheter was invented in order to record action potentials from the bronchial smooth muscle through the intrabronchial lead. Action potentials obtained by this electrode were compared with those obtained by the direct peribronchial needle electrode during either artificial or spontaneous respiration in dogs and a monkey. Electrophotographical analysis confirmed that action potentials obtained by our new electrode were similar in discharge pattern to those by the direct peribronchial needle electrode. The active contribution of the bronchial smooth muscle to the maintenance of the bronchial caliber during spontaneous respiration was observed by our new electrode. Accordingly, this electrode is applicable to electromyographical studies of the bronchial smooth muscle.

Action Potentials↗
PubMed1975

Electromyographic study of bronchial smooth muslce in bronchial asthma.

We succeeded in recording action potentials from the bronchial smooth muscles in 10 healthy males and 20 cases of bronchial asthma by means of the new electrode described by us in the preceding paper (Akasaka et al. 1975). From these electromyographic studies, we presented the direct evidence of spasm of the bronchial smooth muscles as one of the etiological factors responsible for the airway narrowing in asthmatic attack.

Action Potentials↗
PubMed1975

A study of western red cedar-induced asthma.

Seventeen asthmatic patients who were workers dealing with Western Red Cedar in a Japanese wooden frame factory were studied. One fraction from the aqueous extract of the lumber induced a positive skin test, Prausnitz-Kustner test and the inhalation test. This confirms the existence of antigen in Western Red Cedar and its ability to produce allergic asthma in sensitive workers.

Acetylcholine↗
PubMed1975

A study of Western Red Cedar sensitivity: workers' allergy reactions and symptoms.

In 154 individuals who work with Western Red Cedar in Japanese wooden frame factories a high incidence (24.7%) of bronchial asthma was observed. A positive intradermal test was found in 89% of the asthmatics and in 56% of all. A highly positive inhalation test was obtained only in the asthmatic group. It is suggested that other symptoms in addition to bronchial asthma might be caused by Western Red Cedar because of the frequency of positive skin reactions to the Western Red Cedar antigen.

Asthma↗