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S Mortensen

Publications and source records attributed to S Mortensen.

At least 37 records · Page 2Linked to original sources
PubMed1996

Symptomatic outcome of transurethral prostatectomy, alpha-blockade and placebo in the treatment of benign prostatic hyperplasia. Evaluation of treatment with the Danish Prostatic Symptom Score (DAN-PSS-1) system. The ALFECH Study Group.

To assess the symptomatic outcome following transurethral prostatectomy (TURP), alpha-blockade and placebo treatment in uncomplicated benign prostatic hyperplasia (BPH), 260 patients were evaluated with the recently formulated Danish Prostatic Symptom Score (DAN-PSS-1) system: 205 were randomized to either the selective alpha-blocker alfuzosin or placebo and 55 underwent TURP. Following TURP, the DAN-PSS-1 score was reduced by 80% after 6-10 weeks (visit 2) and by 100% after 12-16 weeks (visit 3). In the alfuzosin group the corresponding reductions were 40% and 65% (p < 0.02 vs. placebo). In the placebo group the reduction was 25% at visit 2, with no further fall demonstrated thereafter. During alfuzosin treatment the bother score (impact of symptoms on quality of life) fell more than the symptom score. During placebo treatment there was no reduction in symptom score. We conclude that the DAN-PSS-1 questionnaire sensitively identifies clinically important responses to treatment of BPH.

Adrenergic alpha-Antagonists↗
PubMed1996

The symptomatic outcome of transurethral prostatectomy evaluated with the DAN-PSS-1 score system.

We assessed the symptomatic outcome of transurethral prostatectomy with the newly developed self-administered questionnaire, Danish Prostate Symptom Score (DAN-PSS-1), in men suffering from uncomplicated benign prostatic hyperplasia (BPH). The questionnaire was filled in adequately by 53 men, median age 69 (range 52-82), preoperatively and 2, 4 and 6 months after transurethral prostatectomy (TUR-P). The DAN-PSS-1 symptom score showed a high degree of sensitivity as the preoperative total score was median 20 (quartiles 14-36) and decreased to 4, 0 and 1 (quartiles from 0-4) at the 2, 4, and 6-month control respectively. The symptoms related to voiding were relieved totally after 2 months while symptoms related to storage were first relieved completely at 4-month control. Bother from symptoms was relieved after 2 months, although some symptoms still remained. The questionnaire was internally consistent with a reliability coefficient, Cronbach's alpha (alphaCr), of 0.73. We conclude that the DAN-PSS-1 questionnaire is an efficient tool among others in the indication and evaluation of treatment of uncomplicated BPH.

Aged↗
PubMed1996

Effect of vaccination against Aujeszky's disease compared with test and slaughter programme: epidemiological and economical evaluations.

In January 1990, a 6-year program was initiated to eliminate endemic Aujeszky's Disease virus (ADV) infection from the pig herds in an area of Northern Germany, bordering Southern Denmark, with intensive pig farming. In the first 3 years of the campaign, an intensive compulsory vaccination program, with glycoprotein I (gI)-deleted vaccines, of all pigs in the area was employed. Beginning in June 1990 and for the first 3 years of the project, approximately 200 herds randomly selected from all herds in the area, were serologically tested each quarter. In each farrow-to-feeder (FAFE), feeder-to-finish (FEFI) and farrow-to-finish (FAFI) herd, 20 female breeding pigs, 20 finishing pigs (> or = 50 kgs liveweight) and 10 female breeding pigs and 10 finishing pigs, respectively, were blood sampled. The sera were tested by the Herd-Check Anti-PRV(S) ELISA test (IDDEX Inc., ME). Sera positive to this test were examined by the HerdCheck Anti-ADV gI-ELISA test (IDDEX Inc., ME). Data on potentially confounding management factors were collected through a pilot-tested questionnaire, administered to farmers by 2 veterinarians who blood sampled the pigs. For fattening herds (FEFI and fattening sections of FAFI herds), the association between the odds of > or = 1 gI+ finishing pigs and the time between initiation of the program in the area and sampling date (a surrogate for the effect of the program) was modelled using ordinary logistic regression. The association between the odds of gI+ females in seropositive (> or = gI+ females) FAFE and FAFI herds and time since initiation of the program was investigated with logistic-binomial regression models. Results of the study show that the longer the period from the beginning of compulsory vaccination to the date the herd was sampled the lower the odds of gI+ fattening herds and gI+ female breeding pigs in herds of the area. The beneficial effect of mass vaccination on the reduction of ADV spread was accounted for by this relationship. For fattening herds this relationship appeared curvilinear, with the reduction in the log-odds being more rapid in the 1st year of the program. This non-linear pattern indicates that for the elimination of the risk of ADV-infection from fattening herds of the area, the mass vaccination program should be complemented with additional measures such as test-and-slaughter of infected breeding pigs. A computerized economical model to estimate the effects of ADV-infection at the herd and area level has been developed. The analytical structure consists of a basic epidemiological model linked to an economic estimation framework. The economic model predictions allow priorities to be given to alternative control strategies. Mass vaccination of all pigs in regions with endemically infected herds followed by test-and-removal of seropositive animals is the most cost-effective way to control the spread of ADV within the swine population. Other possible control strategies such as intensive vaccination or complete test-and-removal all had higher overall costs, either because of the less efficient production, or because of the high costs of straight test-and-removal.

Abattoirs↗
PubMed1995

Validation of the self-administered Danish Prostatic Symptom Score (DAN-PSS-1) system for use in benign prostatic hyperplasia.

OBJECTIVE: To validate the Danish Prostatic Symptom Score (DAN-PSS-1), a self-administered quality-of-life questionnaire comprising 12 questions related to voiding problems and the perceived bother of each individual symptom. METHODS: Using published results from several comparisons of other symptom scoring systems with DAN-PSS-1, the test-retest reliability, internal consistency, construct and content validity, and responsiveness of the DAN-PSS-1 system were assessed. RESULTS: The system was internally consistent (Cronbach's alpha = 0.73), the median test-retest reliability of answers to each question was 83.5% (range 0-99.7%) and the questionnaire was well understood by the patients. The DAN-PSS-1 system demonstrated a high degree of construct validity, correlating with the extensively used Madsen-Iversen score system (Spearman's correlation coefficient, rs = 0.51) and with the patients' answers to questions about how bothersome their symptoms were (rs = 0.71). The DAN-PSS-1 system discriminated clearly between patients with benign prostatic hyperplasia (BPH) and control subjects (an area under the receiver operating characteristic curve of 0.94). Finally, the DAN-PSS-1 was sensitive to changes following intervention, with scores decreasing from a median of 20 to zero 4 months after patients underwent transurethral prostatectomy and from a median of 11.5 to 7.5 (65%) after patients had received 4 months treatment with an alpha-blocker. CONCLUSIONS: The DAN-PSS-1 system is reliable, valid and responsive, and therefore can be recommended for assessing the severity of symptoms among patients presenting with lower urinary tract complaints suggestive of BPH and in the follow-up after intervention.

Adrenergic alpha-Antagonists↗
PubMed1994

[Pseudocroup treated with inhaled steroid (budesonide). A double-blind placebo-controlled trial].

The aim of this prospective, randomised, double blind study was to evaluate whether inhaled nebulized corticosteroid is effective in the treatment of croup. Thirty-seven children (aged 0.4-4.9 years) admitted to hospital with moderate to severe croup were allocated to treatment with either 2 mg nebulized budesonide (20) or saline (17). Disease severity was assessed by a clinical croup score based on stridor, cough, retractions, dyspnoea and cyanosis, and the overall clinical assessment was scored on a visual log scale (0-100). Two hours after treatment there was a significant improvement in croup score in the group treated with budesonide (8 to 4.5), but not in the group treated with saline (8 to 8). Furthermore, the overall clinical assessment score decreased significantly (50 to 25) in the group treated with budesonide, whereas it remained constant in the placebo group (60 to 62). The results indicate that nebulised budesonide can be used as a safe and effective alternative treatment in children with moderate to severe croup.

Administration, Inhalation↗
PubMed1994

Characterization of pressure changes in the lower urinary tract during coughing with special reference to the demands on the pressure recording equipment.

The exact demands on urodynamic equipment for measurement of coughs and cough associated pressure changes in the lower urinary tract have been analyzed from high-speed pressure recordings using a double microtip transducer and a storage oscilloscope. The equipment was tested in vitro by the step-test method. The natural frequency response was 175.6 Hz and the rise-time 2.5 ms, resulting in accurate measurements of frequencies up to about 60 Hz, which is way above the clinically measured frequencies. Four men and 2 women, all of whom were healthy volunteers, were examined in the supine position with an empty bladder. Pressures were measured in the bladder and in the external sphincter zone of the urethra. The spectral power density of the bladder and urethral pressures were calculated by Fourier analysis. The pressure changes in the urethra were in all volunteers equal to or slower than in the bladder. The analysis of the spectral power density showed that 99% of the pressure changes could be recorded with an instrument capable of recording 9 Hz frequencies, i.e., with a sampling rate of 18 Hz or more.

Adult↗
PubMed1994

Fractals in uroflows.

Analysis of normal uroflow curves with two different methods give evidence that the uroflow is fractal. It is possible to synthesize uroflow-like curves with the fractal interpolation technique of Barnsley, which may become a way to characterize clinical measurements. Differences between real and synthetic uroflow curves appear when the Lyapunov exponent (a measure of complexity) is calculated: the synthetic curves appear chaotic in this respect, as opposed to the real flow curves.

Humans↗
PubMed1993

Further evidence of long distance airborne transmission of Aujeszky's disease (pseudorabies) virus.

In spite of the eradication of Aujeszky's disease in Denmark a single outbreak was recorded in December 1988 and another severe epizootic took place during the winter and spring of 1989/90. The epizootic occurred in nearly the same areas as the preceding epizootic during the winter of 1987/88. Identification of the strains of virus involved eliminated the possibility that the latest epizootic was due to the persistence of virus in the pig population. Furthermore, as during the preceding epizootic, initial recordings of the new strains were found to coincide with periods with southerly winds. It was concluded from circumstantial evidence that the concurrent introductions of virus to several farms played a major role during the epizootic.

Air Microbiology↗
PubMed1993

Treatment of croup with nebulised steroid (budesonide): a double blind, placebo controlled study.

The aim of this prospective, randomised, double blind study was to evaluate whether nebulised local steroid treatment is effective in the treatment of croup. Thirty six infants and children (0.4-4.9 years of age) admitted to hospital with moderate to severe croup were allocated to receive either 2 mg nebulised budesonide (20 children) or saline (16 children). Disease severity was assessed by a clinical total croup score based on stridor, cough, retractions, dyspnoea, and cyanosis. In addition the overall clinical impression was evaluated (0-100). Two hours after treatment there was a significant improvement in the total croup score in the group treated with budesonide (8 to 4.5), but not in the group treated with saline (8 to 8). Furthermore, the overall clinical impression assessment score decreased significantly (50 to 25) in the group treated with budesonide, whereas it remained constant in the placebo group (60 to 62). The total croup score and overall clinical severity were significantly better in the group treated with budesonide than in the placebo group. No side effects were observed. The results indicate that nebulised budesonide can be used as a safe and effective alternative treatment in children and infants with moderate to severe croup.

Bronchodilator Agents↗
PubMed1990

Evidence of long distance airborne transmission of Aujeszky's disease (pseudorabies) virus.

Aujeszky's disease has been the subject of an eradication campaign in Denmark since 1980. A detailed knowledge of the virus strains present in the country was provided by restriction fragment analyses of older clinical isolates, and of isolates from all the virologically confirmed outbreaks since 1985. The introduction of foreign strains into southern border areas was demonstrated during the winters of 1984/85, 1986/87 and 1987/88. An epizootic during the winter of 1987/88 was shown to correlate with an unusual predominance of southerly winds. Both conventional and specific pathogen free herds became infected. A herd level case-control analysis of the outbreaks during the winter of 1987/88 revealed that there was a positive correlation between the risk of infection and the size of the herd. The observations support the hypothesis of airborne transmission of the disease.

Air Movements↗
PubMed1990

Use of different inhalation devices in children.

Many studies in which patient's inhaler use technique has been studied have shown that one of the major problems patients have, in using an inhaler correctly, is that of poor coordination of inhaler actuation with inspiration. We have studied a new breath-actuated inhaler ("Autohaler" 3M Riker) which is designed to ensure correct coordination automatically. This study involves 100 children (aged 3-10 years) and includes both normal children and asthmatic patients. None of these children have previous experience using any type of inhaler. Each child is taught to use the "Autohaler" containing a placebo only. A video film is employed in order to standardize the teaching technique. Once the child is able to operate the new inhaler correctly, he or she inspires through an "Autohaler" unit specially modified so that the inspiratory flow rate and the volume of air inhaled is measured by a pneumotachograph in series with the inhaler. The time point, within the inspiratory cycle, at which the inhaler is triggered is also recorded. The majority of children older than 7 years were able to use the "Autohaler" after a few minutes instruction. Therefore, this is a valuable alternative in this age group.

Asthma↗
PubMed1982

A planimetric study on the female urethral closure pressure profile.

Integration of the pressures along the functional part of the female urethral profile performed by planimetry adds information to what can be obtained by measuring functional length alone. In 43 patients with urinary stress incontinence, a statistically significant lower area of the profile was found in patients with decreased urethral resistance (diagnosed by pressure-flow study and micturition cystourethrography), whereas patients with cystourethrocele had larger areas than a control group. Patients with cystocele or bladder insufficiency did not differ from the controls.

Adult↗