[Autopsy case of complication of hepatoma with ileocecal reticulum cell sarcoma].
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Autopsy↗
Biomedical subjects
S Morii
Publications and source records attributed to S Morii.
Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz(a)anthracene.
Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.
Adrenal Glands↗
[Two autopsy cases of neuroblastoma manifested initially with ocular symptoms in infants].
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Child, Preschool↗
Adrenocortical damage induced by 7, 12-dimethylbenz (alpha) anthracene and its implication in carcinogenesis.
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Adrenal Gland Neoplasms↗
Loss of basal cell phenotype with acquisition of lung-colonizing capability in mouse mammary tumors.
A transplantable pregnancy-dependent mouse mammary tumor, TPDMT-4, and its ovarian-dependent (T4-OR26) and autonomous (T4-OI96, T4-OI145, T4-OI165, T4-OI320 and T4-OI320CY) sublines were examined immunohistochemically for the expression of keratin 14 and type IV collagen. T4-OI96, T4-OI145, and T4-OI165, but not T4-OR26, T4-OI320, or T4-OI320CY, formed lung colonies (metastasis) after intravenous injection as a single-cell suspension. Despite the similar morphology of TPDMT-4 and its six sublines, only TPDMT-4 and the nonmetastatic sublines revealed a basal cell phenotype as defined by keratin 14 expression. Staining for type IV collagen was complete at the peripheries of the glandular structures in TPDMT-4 and nonmetastatic sublines but was patchy in the metastatic tumors.
Animals↗
Antithrombotic effect of argatroban on the pial vessels of the rat: a study with He-Ne laser-induced thrombus formation.
The antithrombotic effect of the synthetic thrombin inhibitor (2R,4R)-4-methyl-1-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfon yl)-L-arginyl]-2-piperidinecarboxylic acid monohydrate (argatroban) was investigated in cerebral vessels of the rat. An occlusive thrombus was formed in pial vessels using a He-Ne laser in a closed cranial window technique. Argatroban retarded the formation of thrombi in a dose-dependent manner. The antithrombotic effect of a single intravenous dose of argatroban at 0.5 mg/kg was diminished after 30 min in arterioles and after 50 min in venules, respectively. The antithrombotic activity was maintained, however, by continuous intravenous infusion (2 mg/kg/h).
Animals↗
Histology of human eustachian tube muscles: effect of aging.
Forty-eight specimens of human eustachian tube tensor and levator muscles were examined histologically in order to study their functions and the effect of aging. The muscle fibers reach their maximum growth in the third decade with a narrow short diameter: tensor 21.8 micron and levator 24.5 micron; with advancing age, they were prone to atrophy, particularly in the tensor. Three muscle fiber types, red, white, and intermediate, were identified in the tubal muscles. The white fibers predominated in the tensor, and they were a main component of muscle fibers in fetuses and elderly adults. Lipofuscins were located in the periphery of muscle fibers, dominantly in the levator, and became numerous and larger with age. Our observations suggest that 1) the tensor produces a rapid opening of the eustachian tube while the levator creates tension and dilates the pharyngeal orifice of the tube for a relatively long period, and 2) these muscle functions deteriorate with advancing age.
Adolescent↗
Deviation with increasing age in histologic appearance of submucosal glands in human eustachian tubes.
74 tubal specimens from the temporal bones of 37 autopsy cases of various ages (8 fetuses, 12 children, 4 young adults, 36 middle-aged adults, and l4 elderly adults) were examined histologically to study the deviation with increasing age in the submucosal glands of Eustachian tube. The tubal glands consisted of acini (terminal secretory portions) and three duct systems (intercalated, striated and excretory ducts). Cytologically, they were of the mixed type with crescents. It was observed that the mucous acinar cells were predominant in children, as compared with the serous acinar cells. These latter increased prominently in middle age, accompanied by a decrease in the number of mucous cells. Among the elderly, both types of acinar cells decreased and tended to be atrophic. On the other hand, oncocytic changes of the ductal epithelia were discovered in the pharyngeal part of Eustachian tubes of subjects over 60 years old. These aging changes may play an important role in the pathophysiology of patency and excretory processes of the Eustachian tube.
Adolescent↗
Ultracytochemical demonstration of phospholipids in the surface layer of the guinea pig eustachian tube.
The surface layer, especially the extracellular mucous blanket, in the eustachian tube of adult guinea pigs, was preserved very effectively with an intravascular perfusion of twice diluted Karnovsky's fixative following overnight incubation in the same fixative containing 1% tannic acid. Multilamellar bodies were observed in both mucous lining layers of the tube and the epithelial cells of its lining, but neither reticular nor lattice-like ultrastructures could be detected. Mucous blankets on the pharyngeal portion were composed of an electron-dense surface film and a hypophase. The hypophase was marked heterogenous, and it could hardly be observed on the isthmus. The enzymic digestive method using a purified phospholipase A2 was applied to the middle portion of the tube, and the reaction products, probably phospholipids, could be seen both on the surface film of the lining layers and around some of the dark inclusion bodies in the secretory cells. These findings suggest that such phospholipids may play an important role in reducing surface tension of the eustachian tube.
Animals↗
DMBA-induced intestinal tumors in the Japanese house musk shrew, Suncus murinus (Insectivora).
Intestinal tumors were induced in the Japanese house musk shrew, Suncus murinus (Family: Soricidae, Order: Insectivora) with 7,12-dimethylbenz(a)anthracene (DMBA). The animals were divided into 10 groups: groups 1-4 received gastric intubation of DMBA, groups 5-8 received intraperitoneal (i.p.) injections of this agent, and groups 9 (female) and 10 (male) were untreated and served as controls. Group 1 (females) and group 2 (males) received 10 mg DMBA at 50 days of age; group 3 (females) and group 4 (males) received 2 x 10 mg doses at 50 and 55 days of age; groups 5 and 6 (females) received weekly i.p. administration of 1.25 mg (group 5) and 2.5 mg (group 6) for 4 weeks; and groups 7 and 8 (females) received weekly i.p. administration of 1.25 mg (group 7) and 2.5 mg (group 8) for 8 weeks from 8 weeks of age. Intestinal tumors developed in 3/8 (38%) animals in group 1, 2/6 (33%) in group 2, 5/11 (45%) in group 3, 5/10 (50%) in group 4, 3/6 (50%) in group 5, 2/4 (50%) in group 6, 5/8 (63%) in group 7, and 5/6 (83%) in group 8, but not in untreated shrews up to 50 weeks of age. The induced tumors, which began to appear by 15 weeks after the initial treatment, were randomly distributed throughout the intestine. Histologically, the lesions were classified as adenocarcinomas similar to those found in humans. BrdU immunohistochemistry indicated an extension of the proliferative zone and labeling of many neoplastic cells. Local invasion was seen but no metastasis was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
9,10-Dimethyl-1,2-benzanthracene↗
Lectin-binding patterns in transplantable mouse mammary tumors and their metastases.
Lectin binding was assessed in a transplantable pregnancy-dependent mouse mammary tumor line (TPDMT-4), its autonomous sublines (T4-0196 and T4-01165) and their artificial metastases (lung colonies), using the avidin-biotin-peroxidase technique. Soybean agglutinin (SBA) and peanut agglitinin (PNA) bound to the luminal surfaces of TPDMT-4 tumor cells, while dolicos biflorus agglutinin (DBA) showed no binding. In T4-0196 and T4-01165 tumors as well as their lung metastases, SBA and PNA binding was mixed and both positive and negative cells were detected, indicating that these lectins were not associated with the metastatic phenotype. Although the T4-0196 and T4-01165 sublines had a mixture of DBA-positive and DBA-negative cells, all the metastatic T4-0196 subclones contained only DBA-positive cells and all the metastatic T4-01165 subclones had DBA-negative cells. Thus DBA-positive, and DBA-negative subclones had respectively metastasized to the lungs from these autonomous sublines, implying that the carbohydrate moieties detected by DBA were not associated with metastatic potential but that the lung metastases were clonal in origin.
Animals↗
DMBA-induced uterine vascular tumors in BALB/c mice: ovary-dependent carcinogenic response.
Female BALB/c mice treated with a single intraperitoneal injection of 1 mg of 7, 12-dimethylbenz(a)anthracene (DMBA) at 4, 8 and 20 weeks of age showed a high incidence of uterine vascular tumors. Bilateral ovariectomy preceding DMBA treatment almost completely inhibited the induction of vascular tumors, while ovariectomy following DMBA treatment resulted in endometrial gland atrophy and a high incidence of vascular tumors. Vascular tumors were also induced when DMBA was given to neonatal androgenized mice, whereas among neonatal androgenized and normal female mice not treated with DMBA the incidence was 0%. Histological examinations revealed benign hemangiomas or angiosarcomas. In contrast, DMBA-treated male BALB/c mice and orchiectomized mice, and DMBA-untreated males showed no vascular tumors. A striking ovarian dependence of induction of uterine vascular tumors was observed.
9,10-Dimethyl-1,2-benzanthracene↗